SR9009, also known as Stenabolic, is an agonist of the Rev-ErbA protein. It has exhibited the potential ability to increase cardiovascular endurance, stimulate fat loss, improve heart health, and decrease body weight, inflammation, and cholesterol in mice.

SR9009 has also prevented cellular senescence, decreased the viability of cancer cells, and shrunk the size of atherosclerotic plaque in animal studies. Research has further indicated that SR9009 is lethal to chemo-sensitive and chemo-resistant small-lung cancer cells.

Behemoth Labz sells SR9009 for laboratory and research purposes only.

We also carry SR9009 transdermal and SR9009 parenteral solution if you are interested.

• May Reduce Body Fat According to One Study [R]
• May Also Improve LDL Cholesterol and Triglycerides [R]
• Appears to Drastically Improve Cardiovascular Endurance [R]

Keep contents sealed and stored in a cool dry place. Items are shipped in a plain envelope or bubble mailer within 24-48 hours (or the next business day)

Stenabolic, otherwise known as SR9009, is a PPAR delta receptor agonist similar to Cardarine.

It was initially researched by Professor Thomas Burris of the Scripps Research Institute for its ability to increase mitochondria in skeletal muscle tissue.

• CAS Number is stated as 1379686-30-2
• Molar Mass is 437.94026 g·mol−1
• It has a Chemical Formula of C20H24ClN3O4S
• IUPAC Name is ethyl-3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate

The Cardarine for sale from Behemoth Labz is 3rd party tested for the utmost purity.

What is SR-9009?

SR9009 is a synthetic REV-ERB agonist. REV-ERBs are proteins that regulate the circadian rhythm, or the body’s internal 24-hour clock. Circadian rhythms, in turn, control various body functions, including sleep-wake cycles, fat burning and storage, and body temperature. [R][R]

SR9009 was initially discovered in 2012 at Scripps Research Institute. In one of its first studies, SR9009 demonstrated the potential ability to stimulate significant fat loss and reduce body weight. Mice injected with Stenabolic for a week lost weight due to a reduction in fat mass. [R]

Stenabolic might also protect heart health in various ways. Besides reducing the size of atherosclerotic plaque in blood vessels, SR9009 reduced blood levels of total cholesterol and triglycerides in mice. High levels of cholesterol and triglyceride are harmful to the heart. [R][R]

Recent research has explored SR9009’s anti-cancer effects. A pre-clinical study has found that it potentially inhibits chemo-sensitive and chemo-resistant small lung cancer cells. Another study has shown that Stenabolic may potentially exert a cytotoxic effect on different types of cancer cells. [R][R]

How does SR-9009 Work?

SR9009 works by potentially binding/activating REV-ERBα in the body. REV-ERBα is one of two REV-ERB agonists, the other being REV-ERBβ. Research has indicated that REV-ERBα is highly expressed in oxidative skeletal muscle and that its deficiency in muscle leads to compromised exercise capacity. [R]

Experiments have indicated that REV-ERBα activation improves muscle oxidative function. In addition, the pharmacological activation of this REV ERB increases exercise capacity. All the effects linked to SR9009 stem from its potential activation of REV-ERBα.

SR-9009 Vs SR-9011

SR9009 and SR9011 are both synthetic REV-ERB agonists. Effects of both observed in vitro and in vivo animal studies include increased basal oxygen consumption, decreased lipogenesis, cholesterol, and bile acid synthesis in the liver, and increased fatty acid oxidation in the liver. [R]

The observed increase in energy expenditure and decrease in fat mass make the REV-ERB agonists SR9009 and SR9011 promising candidates for the treatment of several metabolic disorders. Still, neither of them is approved for therapeutic use anywhere in the world. [R][R]

Stenabolic Research

Various animal and cell-based studies have been conducted on Stenabolic. These have demonstrated the potential effects of SR9009 on body weight, cellular senescence, heart health, physical endurance, cancer cells, and sleep/wakefulness patterns.

All the information presented below is for educational purposes only and does not constitute medical advice. It is drawn from preclinical research.

Stenabolic and Weight Loss

In an animal study, SR9009 treatment caused weight loss in three mice groups.

The first group consisted of mice with normal body weight. All the subjects of this group lost significant weight after being administered SR9009 for 7 days. Researchers conducting the study noted that the weight reduction was due to a decrease in fat mass. [R]

The second and third groups were made up of diet-induced and genetically obese mice. In the former group, SR9009 injected for 30 days caused a 60% higher weight loss than in control animals. Genetically obese mice stopped gaining weight after 12 days of Stenabolic treatment.

Stenabolic and Cellular Senescence

Senescence, also known as aging, is the time-related deterioration of body cells. Symptoms of senescence include increased susceptibility to chronic diseases and infection and loss of resistance to internal and external stressors. Senescent cells may also cause heart diseases. [R]

In mouse models of therapy-induced and oncogene-induced senescence, SR9009 counteracted cellular senescence induced by persistent DNA damage. SR9009’s suppressive effects on the aging of cells were mediated by inhibiting ROS levels through the NRF2 pathway. [R]

SR9009 increased the expression as well as the nuclear translocation of NRF2. NRF2 activates the transcription of several antioxidant genes known for counteracting ROS to alleviate senescence. In summary, Stenabolic could suppress senescence in vitro and in vivo.

Stenabolic and Heart Health

SR9009 could potentially improve heart health in various ways.

Mice administered SR9009 for 7 to 10 days had reduced triglycerides and total cholesterol levels at the end of the treatment period. In another study, SR9009 treatment reduced total cholesterol, triglycerides, and LDL cholesterol in mice on a high-cholesterol diet. [R][R]

In another mice study, genetically modified mice susceptible to the hardening of the arteries were administered SR9009 for seven weeks. Results from the study indicate that SR9009 treatment reduced the size of the blood vessel lesions without affecting food intake. [R]

Similarly, in mice with surgically induced heart growth, Stenabolic administered for 14 days reduced heart size and weight. In the same study, Stenabolic injected for 4 weeks improved heart function in both normal as well as genetically modified old mice. [R]

Stenabolic and Cancer

A cell-based study explored the efficacy of SR9009 for the treatment of small-lung cancer cells (SCLC). It found that Stenabolic is specifically lethal to both chemo-sensitive and chemo-resistant SCLC cells, indicating SR9009 as a potential therapeutic strategy in 1^st or 2^nd-line SCLC treatment. [R]

Another cell-based study went a step further. It found that SR9009 treatment exerts a cytotoxic effect on cancer cells derived from different tumor types, namely brain, leukemia, breast, colon, and melanoma. Another REV-ERBs agonist (SR9011) displayed similar properties.

Notably, while SR9009 and SR9011 are effective against tumor lines, they have little or no toxic effects on normal cells at comparable concentrations. In summary, the anti-tumor activity of these REV-ERB agonists is effective against a broad spectrum of tumors. [R]

Stenabolic and Circadian Clock

Administration of REV-ERB agonists (SR9009 and SR9011) altered circadian behavior and core clock gene expression patterns in hypothalamic mice. The alteration of circadian pattern expression resulted in an increase in energy expenditure.

The circadian clock regulates sleep-wake patterns, metabolism, and various other functions in your body. The results mentioned above thus suggest that SR9009 and SR9011 may hold utility in the treatment of sleep disorders as well as metabolic diseases. [R]

Stenabolic and Wakefulness

Animal studies have indicated that mice injected with SR9009 during the daytime were more active during the day and had less sleep. These studies further establish that SR9009 does not lose efficacy when administered more than once a day, nor does tolerance develop. [R]

Furthermore, through the use of a time response paradigm, it was determined that there is an optimal time for the administration of SR9009 in terms of maximal efficacy. In addition, there was a 12-hour window in which this synthetic REV-ERB agonist elicited a response.

Stenabolic and Inflammation

A mice study has highlighted the anti-inflammatory role of SR9009 in endotoxin-induced inflammation. The study showed that pharmacological activation of REV-ERBα with Stenabolic significantly suppressed the lipolysaccharide (LPS)-induced inflammation in vitro and in vivo. [R]

Stenabolic and Endurance

A mice study was conducted to explore the effects of SR9009 on endurance. One of the study’s groups was administered SR9009 for 30 days and the effects were noted. It was found that mice treated with SR9009 covered more distance and ran for a longer time than controls. [R]

Stenabolic and Anxiety

Stenabolic treatment for 3 to 10 days reduced anxiety-like behavior in mice. SR9009 was administered twice a day for the entire treatment period. Notably, the effects of SR9009 on anxiety reduction were as potent as those of benzodiazepine, a standard anti-anxiety drug. [R]

Frequently Asked Questions

Does SR9009 Have The Potential to Burn Fat?

In multiple animal studies, SR9009 has demonstrated the ability to burn fat. These studies involved normal mice, diet-induced obese mice, and genetically obese mice. All three experienced decreased lipogenesis after SR9009 treatment.

Is SR-9009 a SARM?

SR-9009 is not a selective androgen receptor modulator. It is a synthetic REV-ERB agonist that has demonstrated the ability to reduce fat-storing cells, increase lean muscle mass, and improve cholesterol levels. However, SR 9009 is yet to attract clinical research.

Where to Buy SR-9009 for Sale?

Behemoth Labz is the best place to buy SR-9009 online.

We have been around since 2014, supplying the highest-quality research compounds money can buy. All of our products come with a 100% satisfaction guarantee, free and fast shipping, and a money-back guarantee. We carry SR-9009 liquid, SR-9009 transdermal, and SR-9009 parenteral solution for laboratory research use only.

Conclusion

In various animal and cell-based studies, SR-9009 has exhibited a potential ability to treat obesity, improve heart health and inhibit the action of various cancer cells. This REV-ERB agonist has also demonstrated positive effects on endurance and on lipid and glucose metabolism.

Behemoth Labz doesn't sell SR-9009 Stenabolic for human consumption.

Behemoth Labz Disclaimer

Please make sure you go through the Terms and Conditions, and please familiarize yourself with it as it is important. Please research the scientific uses of this product before making any purchases. Make note that the packaging and labels of the product may differ from those shown on the website.
Buying the product means you agree with our Terms and Conditions. You can contact our awesome customer service team at support@behemothlabz.com if you are not fully satisfied with the product. Customer satisfaction is our number one priority!

ATTENTION: All BehemothLabz products are strictly for LABORATORY AND RESEARCH PURPOSES ONLY. They are not to be used for any human or veterinary purposes.

DMAA, or 1,3-dimethylamylamine, is a synthetic compound that has been used in various applications. Originally introduced as a nasal decongestant, DMAA later found use in different industries. It gained popularity in certain products due to its stimulating properties. While preclinical studies suggest potential benefits for sports performance, it’s crucial to emphasize that these effects must be substantiated through clinical trials.

How 1,4 DMAA Works?

DMAA, or 1,3-dimethylamylamine, is thought to potentially enhance physical performance through its sympathomimetic effects on the sympathetic nervous system. By mimicking neurotransmitters like epinephrine, norepinephrine, and dopamine, DMAA has the potential to trigger a heightened stimulation response that can lead to various athletic performance-related benefits.

One primary mechanism involves the potential increased release of adrenaline and noradrenaline, hormones crucial for the body’s “fight or flight” response. This heightened hormonal release can translate into a faster heart rate, improved oxygen supply to muscles, and increased energy availability. Consequently, test subjects may observe enhanced endurance, heightened alertness, and elevated energy levels. 

Furthermore, DMAA’s sympathomimetic properties may induce vasoconstriction, causing blood vessels to narrow. This effect can enhance blood flow and oxygen transport to muscles, potentially contributing to improved exercise performance and endurance. Additionally, some report a subjective sense of euphoria, which could positively impact motivation and the perceived effort during physical activities. 

Note: It’s essential to acknowledge that the use of DMAA for performance enhancement is a subject of debate, with concerns raised about its safety and efficacy. Due to limited research and potential health risks. BehemothLabz provide DMAA for research; it is not meant for human consumption.

Chemical Properties of 1,4 DMAA

• CAS Number: 105-41-9
• Molar Mass: 115.22 g/mol
• Chemical Structure Formula: C7H17N
• IUPAC Name: 4-methylhexan-2-amine
• Also known by Synonyms as: 1,3-Dimethylpentylamine, 4-methylhexan-2-amine, Methylhexaneamine, Forthane, 1,3 dmaa

Potential Research Applications for 1,4 DMAA Liquid

DMAA and Physical Performance Potential 

There was a recent study in Mainz, Germany, that looked at how common and why people use nutritional supplements (NS) when they go to fitness classes. The study focused on new multi-ingredient supplements like pre-workout boosters (PWBs). Some PWBs, like enhancers like DMAA( geranium plants), N,α-DEPEA, DMAE, and DMBA, may have risks, harms, and benefits that we don’t fully understand yet. Out of the 492 people polled in 13 fitness studios, 57.0% said they had used NS in the last four weeks.

The study shows that using pre-workout boosters (PWBs) is linked to several things, such as gender, training regularity, and the reason for wanting to improve sports performance. This powder, which might contain stimulants like DMAA, is connected to predictor variables like wanting to improve mental focus ability and competing. It is important to remember that these substances are not meant to be eaten. This adds to the ongoing debates in the exercise community about what these supplements might mean for people, as this may lead to adverse events. 

DMAA and Memory Studies

In another study, a dietary supplement containing caffeine and DMAA showed some interesting effects on the central nervous system, particularly in memory and mental speed when taken 30 minutes before testing. Subjects experienced a slight improvement in memory, visual processing speed, and reaction time. However, the changes were not very big, and it’s still unclear if they are important for real-life situations. The study couldn’t figure out if it was the caffeine or the DMAA that was mainly responsible for these effects. Also, researchers haven’t looked specifically at the effects of DMAA by itself on these mental abilities. So, while the results are intriguing, more research is needed to fully understand how DMAA and other ingredients in the supplement might affect mental performance. 

DMAA and Metabolic Research

Recent data suggest that a dietary supplement containing DMAA may play a role in promoting fat loss among 32 healthy test subjects. The study focused on exercise-trained models, revealing that the supplement potentially aids in fat loss without causing adverse effects on resting blood pressure or key safety markers in the blood. It’s noteworthy that while the supplement demonstrated overall safety, a slight increase in resting heart rate was observed. These findings shed light on the potential of DMAA to contribute to weight management without compromising cardiovascular safety. 

Please note that DMAA is intended for research purposes only; it is not meant for human consumption. Further research is still needed to establish statistically significant studies on free fatty acids. 

DMAA and Cholesterol

Previous studies on 1,3-dimethylamylamine have shown that it causes a short-term rise in blood pressure, mostly at the systolic level.  A study with 25 people over 10 weeks found that a supplement with 1,3-dimethylamylamine did not significantly raise their steady heart rate or blood pressure. The supplement only slightly raised systolic blood pressure by about 6 mmHg. Notably, health factors in the blood, such as creatinine and alkaline phosphatase, changed over time, but there were no big differences between the supplement group and the placebo group. A big change in low-density lipoprotein cholesterol (LDL-C) levels showed that the supplement group had a drop of about 7 mg · dL(-1). Please keep in mind that this compound should not be consumed. More research is needed with a longer intervention period, a bigger sample size, and more health and safety measures. 

Where to Buy 1,4 DMAA Online?

Behemoth Labz is the best place to buy DMAA. We provide DMAA for sale, and it is available for research purposes only.

We have been around since 2014, supplying the highest-quality research compounds money can buy. All of our products come with a 100% satisfaction guarantee, free shipping, and a money-back guarantee. 

BehemothLabz Disclaimer

Please make sure you go through the Terms and Conditions, and please familiarize yourself with them as they are important. Please research the scientific uses of this product before making any purchases. Make note that the packaging and labels of the product may differ from those shown on the website.

Buying the product means you agree to our Terms and Conditions. You can contact our awesome customer service team at support@behemothlabz.com if you are not fully satisfied with the product. Customer satisfaction is our number one priority!

ATTENTION: All Behemoth Labz products are strictly for LABORATORY AND RESEARCH PURPOSES ONLY. They are not to be used for any human or veterinary purposes.

Reference Links

J Bloomer, R. (2018). 1,3-Dimethylamylamine (DMAA): A Brief History and Review of Anecdotal and Laboratory Findings. Journal of Alternative, Complementary & Integrative Medicine, 4(3), 1–11. https://doi.org/10.24966/acim-7562/100057

Dreher, M., Ehlert, T., Simon, P., & Neuberger, E. W. I. (2018). Boost Me: Prevalence and Reasons for the Use of Stimulant-Containing Pre-Workout Supplements Among Fitness Studio Visitors in Mainz (Germany). Frontiers in Psychology, 9. https://doi.org/10.3389/fpsyg.2018.01134

Powers, M. E. (2015). Acute Stimulant Ingestion and Neurocognitive Performance in Healthy Participants. Journal of Athletic Training, 50(5), 453–459. https://doi.org/10.4085/1062-6050-50.1.07

McCarthy, C. G., Canale, R. E., Alleman, R. J., Reed, J. P., & Bloomer, R. J. (2011). Biochemical and anthropometric effects of a weight loss dietary supplement in healthy men and women. Nutrition and Metabolic Insights, 5, 13–22. https://doi.org/10.4137/NMI.S8566

Ryzhenkov, V. E., Ogurtsov, R. P., Trubacheva, V. V., Popov, V. G., & Puzyreva, V. P. (1988). Effect of thymalin on the development of experimental hyperlipidemia and atherosclerosis. Voprosy Meditsinskoi Khimii, 34(1), 51–56. https://pubmed.ncbi.nlm.nih.gov/2967015/