Sildenafil – Product Details

Sildenafil is an active ingredient that can be used in the treatment of erectile dysfunction (ED). It could be a prescription medication that could help male subjects experiencing erectile issues. [R]

Sildenafil belongs to a class of chemical compounds called phosphodiesterase type 5 (PDE5) inhibitors and is commonly sold under the brand name Viagra or in a generic form known as generic Viagra.

Sildenafil is believed to work by relaxing the blood vessels in the penis, which allows for increased blood flow to the area. This increased blood flow may help test subjects with ED achieve and maintain an erection during sexual activity. This result should be done with the recommended per dose of Sildenafil.

It’s important to note that Sildenafil cannot increase sexual desire or libido, nor does it protect against sexually transmitted infections. It’s also not recommended for test subjects with certain medical conditions. In some cases, a research subject undergoes online consultation to determine if they are qualified for the study.

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• CAS Number: 139755-83-2
• Molar Mass: 474.6 g/mol
• Chemical Formula: C22H30N6O4S
• IUPAC Name: 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine
• Synonyms: Sildenafil citrate, Viagra, Revatio, Sildenafilum, Sildénafil, Sildenafil citrát, Sildefil, Silagra, Suhagra, Intagra, Kamagra, Caverta, Penegra, Zenegra, Edegra.

What is Sildenafil Citrate?

Sildenafil Citrate is a potential medication primarily used to treat erectile dysfunction (ED). It is a possible ED medication that may be categorized into the class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors.

Researchers believe that Sildenafil works by increasing blood flow to the penis during sexual stimulation, which helps to achieve and maintain an erection.

Sildenafil Citrate is most commonly sold under the branded name Viagra, but it is also available in branded Viagra. It is important to note that Sildenafil Citrate is not a cure for ED, nor does it increase sexual desire. It only works when sexual stimulation is present.

In addition to its use for ED, Sildenafil Citrate is also being studied for its effects on other health conditions, such as pulmonary arterial hypertension (PAH).

Today, some generic medications of Viagra could be available but beware of counterfeit drugs. To avoid these harmful compounds, purchase Viagra online from FDA-approved online pharmacies.

Possible Uses of Sildenafil Citrate

Treatment of Erectile Dysfunction

Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor that works by increasing blood flow to the penis during sexual stimulation, thereby improving erectile function. Clinical studies have shown that sildenafil is highly effective in treating ED, with a success rate of up to 80% in men of various ages and underlying causes. [R]

According to a randomized, double-blind, placebo-controlled study published in the Journal of Sexual Medicine, Sildenafil was shown to significantly improve the International Index of Erectile Function (IIEF) score in men with ED, regardless of age or cause. [R]

Other research reports have also shared similar results, with Sildenafil being effective in male subjects with diabetes, hypertension, depression, and post-prostatectomy ED. [R]

Lowering Blood Pressure

Sildenafil has been shown to have a mild blood pressure-lowering effect, which may be beneficial for test subjects with hypertension. A specific study published in the Journal of the American College of Cardiology shows that Sildenafil significantly reduces both systolic and diastolic blood pressure in men with hypertension. [R]

However, this effect is typically mild and may not be sufficient as the sole treatment for hypertension. Moreover, the Sildenafil should not be taken concomitantly with nitrates, as this can cause a significant drop in blood pressure. [R]

Treatment of Pulmonary Hypertension

Sildenafil is approved by the FDA for the treatment of pulmonary arterial hypertension (PAH), a condition in which the blood pressure in the lungs is abnormally high. PAH is a progressive and potentially life-threatening condition that affects the heart and lungs, leading to shortness of breath, fatigue, and chest pain. [R]

Clinical studies have shown that sildenafil significantly improves exercise capacity and quality of life in patients with PAH. A randomized, double-blind, placebo-controlled study published in the New England Journal of Medicine found that sildenafil improved exercise capacity, pulmonary hemodynamics, and quality of life in patients with PAH. [R]

Other studies have also reported similar results, with sildenafil being effective in reducing symptoms and improving survival in patients with PAH. [R]

Relief of Chest Pain

Sildenafil has been shown to improve symptoms of angina, a type of chest pain caused by reduced blood flow to the heart. Based on the International Journal of Cardiology, Sildenafil demonstrated the property to significantly improve exercise tolerance and reduce the frequency of angina attacks in patients with stable angina. [R]

This effect is thought to be due to the vasodilatory properties of sildenafil, which can increase blood flow to the heart and relieve ischemic symptoms. [R]

How Does Sildenafil Work

The mechanism of action of Sildenafil in the human body involves the inhibition of phosphodiesterase type 5 (PDE5), an enzyme that regulates the levels of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the penis, lungs, and other tissues. By inhibiting PDE5, sildenafil increases the levels of cGMP, which in turn relaxes smooth muscle tissue and increases blood flow to the penis during sexual stimulation, resulting in improved erectile function.

In addition to its effects on the penis, Sildenafil could also relax the smooth muscle tissue in the pulmonary arteries, leading to a reduction in pulmonary blood pressure. This property of Sildenafil may possibly help treat pulmonary arterial hypertension (PAH), a condition in which the blood pressure in the lungs is abnormally high.

Overall, the mechanism of action of sildenafil involves the inhibition of PDE5, leading to increased levels of cGMP and relaxation of smooth muscle tissue, resulting in improved blood flow and improved erectile function in men with ED, and reduced pulmonary blood pressure in patients with PAH.

Safety and Side Effects

Common side effects of sildenafil include headaches, flushing, nasal congestion, and indigestion. In rare cases, sildenafil can cause more serious side effects, such as sudden vision loss, hearing loss, or priapism (an erection that lasts longer than 4 hours). Moreover, Sildenafil should not be taken concomitantly with nitrates, alpha-blockers, or other drugs that can lower blood pressure.

Frequently Asked Questions

How is Sildenafil (Viagra) made available?

Sildenafil may be available in one’s local pharmacy or it could be available from an online pharmacy. To purchase this chemical compound, the buyer would be required to show a Viagra prescription.

Generic Sildenafil is available as a prescription chemical, and should only be used under the guidance of a healthcare professional.

How long does sildenafil last?

The effects of sildenafil can last up to 4-5 hours, depending on the individual and the dose taken. However, it is important to note that sildenafil does not cause an erection without sexual stimulation.

Can women use sildenafil?

While sildenafil is primarily used to treat erectile dysfunction in men, it has also been studied for use in women with sexual arousal disorder. However, it is not currently approved for use in women.

How does sildenafil work?

Sildenafil works by inhibiting an enzyme called phosphodiesterase type 5 (PDE5), which regulates the levels of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the penis and lungs. By inhibiting PDE5, sildenafil increases the levels of cGMP, which leads to the relaxation of smooth muscle tissue and increased blood flow to the penis during sexual stimulation, resulting in improved erectile function.

In the lungs, sildenafil can reduce pulmonary blood pressure by relaxing smooth muscle tissue in the pulmonary arteries.

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Summary

Sildenafil is a medication that is primarily used to treat erectile dysfunction (ED) in men. It is available in both the branded form of Viagra and a generic version and should only be obtained with a prescription from a licensed medical professional. Sildenafil is more effective than herbal supplements or over-the-counter ED pills and can improve erectile function in men when taken as directed.

While sildenafil can have some potential side effects, such as upset stomach or headaches, these are typically mild and can be managed. However, if more serious adverse effects occur, such as sudden vision loss or hearing impairment, immediate medical attention should be sought.