Vardenafil – Product Details

Vardenafil is a medication used to treat erectile dysfunction (ED) in men. It could work in the same way as Viagra. ED is a condition where a man has difficulty getting or maintaining an erection firm enough for sexual activity. [R]

Vardenafil, a prescription-based medication, falls within the category of drugs known as PDE5 inhibitors. Its mechanism involves enhancing blood flow, potentially aiding in physiological responses during certain conditions. It is essential to note that vardenafil is intended for research purposes only and not for human consumption. The described effects are related to their researched impact on physiological processes and should not be construed as medical advice or usage guidance.

Vardenafil was approved for use in the United States in 2003 and is sold under the brand names Levitra and Staxyn. When used as directed by a healthcare provider, vardenafil is generally safe and effective for treating ED. [R]

Some preliminary research also indicates Vardenafil may provide additional benefits, like improving benign prostatic hyperplasia symptoms, lowering blood pressure, and increasing exercise capacity in some patients. However, more studies are needed to confirm these potential benefits.

The most common potential side effects of vardenafil are headache, flushing, nasal congestion, indigestion, and dizziness. It should not be taken with certain medications or medical conditions.

• CAS Number: 224785-91-5
• Molar Mass: 488.604 g/mol
• Chemical Formula: C23H32N6O4S
• IUPAC Name: 1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-piperazine
• Synonym: Vardenafil hydrochloride

It is important to note that Vardenafil is still not recommended for human consumption and is deemed unsafe. It should only be used for research studies to determine its efficacy. Behemoth Labz provides information on S-Drol for research purposes only.

What is Vardenafil?

Vardenafil is a medication used to treat erectile dysfunction (ED) in men ages 18 years and older. It was approved by the FDA in August 2003 and is sold under the brand names Levitra and Staxyn.

Vardenafil functions by inhibiting the PDE5 enzyme, promoting increased blood flow to specific areas. This mechanism aids in experimental scenarios related to physiological responses. The suggested initial dose is 10mg, administered in subjects about an hour before the planned experimental session, with a maximum frequency of once daily.

Preliminary investigations suggest potential auxiliary effects of vardenafil, such as addressing symptoms associated with benign prostatic hyperplasia (BPH), influencing blood pressure, and potentially enhancing exercise capacity in select subjects. Nevertheless, further comprehensive studies are imperative to substantiate these findings. Vardenafil, as a compound, may also exhibit attributes conducive to supporting recovery after strenuous physical activity.

The constituents of Levitra pills and analogous vardenafil formulations predominantly encompass vardenafil hydrochloride trihydrate alongside inert components. Based on available clinical data, caution is warranted concerning potential interactions with medications containing nitrates, alpha-blockers, specific antifungals, and others, as this may lead to an undesirable reduction in blood pressure.

Individuals with pre-existing conditions such as heart ailments, liver or kidney disorders, stomach ulcers, bleeding tendencies, eye complications, or known allergic reactions to vardenafil should exercise prudence or abstain from vardenafil use. Moreover, simultaneous use with amyl nitrite (“poppers”) or grapefruit juice should be avoided due to potential interactions.

The most common potential side effects are headache, flushing, nasal congestion, indigestion, dizziness, and back pain. More serious side effects like vision or hearing loss, chest pain, irregular heartbeat, and prolonged erections require immediate medical attention.

Vardenafil has the same active ingredient as Levitra. Read about Vardenafil online for research purposes alone.

Possible Research Uses of Vardenafil

Vardenafil and Erectile Dysfunction

Multiple clinical trials have shown vardenafil is highly effective in improving erectile function in men with ED.

One study compared vardenafil to placebo in over 700 male subjects with ED. Men taking vardenafil had significantly better erections and were more successful at completing intercourse than those taking placebo. [R]

Another large study looked at vardenafil in male subjects with diabetes and ED. Vardenafil improved erections in about 80% of the male subjects compared to 30% taking a placebo. The subjects reported vardenafil allowed them to have satisfactory intercourse. [R]

Research also finds vardenafil works faster than some other ED drugs. In a study comparing drugs, vardenafil started working in 16 minutes on average vs 36 minutes for its competitor. [R]

Additionally, a meta-analysis of studies found vardenafil provided firmer, more rigid erections compared to other known brands. Maintaining rigid erections is key for penetration and satisfaction. [R]

Beyond efficacy, studies show male subjects prefer taking vardenafil over other options. In one study, significantly more men preferred vardenafil due to factors like speed of onset, hardness of erections, and ability to complete intercourse successfully.

Vardenafil and Improved Symptoms of Benign Prostatic Hyperplasia (BPH)

In addition to treating erectile dysfunction, some research indicates vardenafil could benefit test subjects with benign prostatic hyperplasia (BPH). BPH involves enlargement of the prostate that can lead to bothersome urinary symptoms.

One clinical trial looked at vardenafil in male subjects with both BPH and erectile dysfunction. The test subjects took either vardenafil or placebo daily for 8 weeks. The study found vardenafil significantly improved several urinary symptoms compared to placebo. [R]

Specifically, vardenafil reduced the frequency and urgency of urination. It also strengthened the stream of urine. And it decreased the amount of time it took to fully empty the bladder. Overall, the researchers concluded vardenafil provided significant relief for the common urinary issues that accompany BPH.

The reason vardenafil helps is that it relaxes muscles throughout the body, including the prostate and bladder muscles. This smooth muscle relaxation reduces obstruction and improves urine flow.

Vardenafil and Lowered Blood Pressure

A comprehensive analysis combined data from multiple high-quality clinical trials on vardenafil. One study found test subjects taking vardenafil had modest but meaningful reductions in blood pressure compared to men not taking the drug. On average, vardenafil lowered systolic blood pressure (the top number) by 3-4 mmHg and diastolic pressure (bottom number) by 1-2 mmHg. [R]

The blood pressure-lowering effect was even greater in test subjects who already had hypertension. Their systolic pressure decreased by over 6 mmHg on average. Even small decreases in blood pressure like this can reduce the risks of heart attack, stroke, and kidney disease.

Researchers believe vardenafil may lower blood pressure through arterial dilation and other vascular effects that reduce resistance and increase blood flow. However, more studies are still needed on the exact mechanisms.

Vardenafil and Increased Exercise Capacity

Some preliminary research shows vardenafil may improve exercise ability in individuals with reduced lung capacity.

One small study looked at clinical subjects with pulmonary arterial hypertension, which constricts arteries in the lungs. This condition can make any exertion extremely difficult.

The study compared vardenafil 10mg twice daily versus placebo over 12 weeks. The participants performed exercise tests on a treadmill. [R]

By the end of the study, those taking vardenafil were able to walk on average 55 meters farther during the exercise test compared to their baseline. The placebo group showed no difference.

The researchers concluded that vardenafil significantly increased exercise ability and stamina in these patients. Their heart rates also recovered faster after exercise while taking vardenafil.

It’s believed the improvements are due to vardenafil’s effects on relaxing blood vessels and increasing oxygen circulation. This enhances the delivery of oxygen to working muscles during physical exertion.

Vardenafil and Muscle Recovery

A study looked at the effects of sildenafil, another drug similar to vardenafil, on muscle strength and fatigue.

The researchers measured knee muscle strength in the subjects at the start and end of the 8-day study. They found knee muscle strength did not change with vardenafil compared to placebo. [R]

However, the subjects taking sildenafil were able to complete significantly more repetitions of knee exercises at the end of the study compared to their baseline before treatment.

This suggests that even though absolute muscle strength did not increase, the research chemical helped improve muscular endurance and resistance to fatigue. The test subjects could work harder for longer after taking the drug.

The researchers believe this effect is due to the ability of vardenafil to increase blood flow. More blood flow provides working muscles with more oxygen and nutrients. It also removes fatigue-causing waste products.

While more research is needed, these results indicate investigative chemicals such as vardenafil could potentially help boost muscular endurance and workout capacity by enhancing blood flow to active muscles. This may support faster muscle recovery between exercise sessions.

Vardenafil and Neuroprotective Effects

In lab studies using rodent models, vardenafil has shown a potential to guard nerve cells against damage from conditions like stroke, Alzheimer’s disease, and Parkinson’s disease.

For example, one study found pretreating mice with vardenafil significantly reduced brain lesion size and neurological deficits caused by induced stroke. Other studies indicate vardenafil may shield dopamine-producing neurons often impacted in Parkinson’s disease. [R]

Scientists believe these neuroprotective effects are due to vardenafil’s ability to enhance blood flow in the brain and suppress inflammation, oxidative stress, and cell death pathways.

However, it is important to note all of these findings come from animal research. Rigorous clinical trials are still needed to determine if vardenafil has similar neuroprotective properties in humans and at normally prescribed dosages.

How Does Vardenafil Work?

Vardenafil works by inhibiting the enzyme phosphodiesterase type 5 (PDE5). PDE5 breaks down cyclic guanosine monophosphate (cGMP), a chemical that plays an important role in erectile function.

When sexual arousal occurs, nitric oxide is released in the penis. Nitric oxide activates an enzyme called guanylate cyclase, which causes increased levels of cGMP. This cGMP causes the smooth muscle cells in the walls of the blood vessels supplying the penis to relax. When they relax, blood can flow more freely into the penis and fill the spongy erectile tissue.

By inhibiting PDE5, vardenafil allows cGMP levels to remain elevated for longer. The increased cGMP keeps blood vessel smooth muscle relaxed, allowing sustained increased blood flow into the penis. This results in an erection that is rigid enough for sexual activity.

The effects of vardenafil last for around 4-5 hours, during which time an erection can be achieved and maintained as long as sexual stimulation is ongoing. After this time, PDE5 levels recover and break down cGMP once again. Blood flow decreases and the erection recedes.

Safety and Side Effects

Here are the potential side effects of vardenafil in subjects:

• Headache – Headaches are a common side effect of vardenafil. They tend to be mild in intensity.
• Flushing – Vardenafil can cause flushing or redness of the face, neck, chest, or other areas of skin. This results from the dilation of blood vessels.
• Dizziness – Some test subjects may experience lightheadedness or dizziness when taking vardenafil due to temporary lowering of blood pressure.
• Vision changes – Vardenafil can cause increased sensitivity to light, blurred vision, or altered color differentiation, especially between blue and green. These vision effects are typically mild and temporary.
• Nausea – Stomach upset or nausea may occur as a reaction to vardenafil.
• Nasal congestion – Vardenafil dilates blood vessels which can lead to stuffy or runny nose. This is generally mild.
• Back pain – A small percentage of test subjects report back pain after taking vardenafil. The lower back and muscle areas are most commonly affected.
• Diarrhea – Some clinical participants experience loose stools or diarrhea when taking vardenafil, especially at higher doses.
• Rash – Skin rashes and hypersensitivity reactions have been reported in a small number of vardenafil tests.

Frequently Asked Questions

Can Vardenafil Potentially treat erectile dysfunction?

Yes, vardenafil is an effective treatment for erectile dysfunction (ED) in men. Vardenafil is a phosphodiesterase type 5 (PDE5) inhibitor that was approved by the FDA specifically for treating ED in 2003. [R]

Numerous clinical studies have demonstrated that vardenafil improves erectile function and enables men with ED to have successful intercourse. In trials, around 80% of men taking vardenafil reported improved erections and the ability to complete intercourse satisfactorily.

Does Vardenafil potentially react with other medications?

Here are some key points about vardenafil interacting with other medications:

• Nitrates: Vardenafil should not be combined with medications containing nitrates, such as nitroglycerin for angina, due to the potential risk of dangerously low blood pressure. A time interval of at least 6 to 8 hours is advised between vardenafil and nitrate administration.
• Alpha-blockers: Caution is advised when using alpha-blocker medications concurrently with vardenafil, as it may lead to dizziness or low blood pressure. Physicians recommend spacing vardenafil and alpha-blocker doses several hours apart.
• Antibiotics: Certain antibiotics, notably erythromycin and clarithromycin, may inhibit vardenafil metabolism, leading to increased levels. Lower vardenafil doses are advisable when using these antibiotics.
• Antifungals: Similar to antibiotics, some antifungal medications may interfere with vardenafil breakdown, potentially amplifying its effects. Azole antifungals are more likely to interact.
• High Blood Pressure Medications: Calcium channel blockers and other blood pressure-lowering drugs, when combined with vardenafil, may further reduce blood pressure. Monitoring for symptoms of low blood pressure is recommended.
• Seizure Medications: Drugs like phenytoin and phenobarbital can enhance vardenafil clearance from the body, potentially reducing its effectiveness. Adjustments to vardenafil doses may be necessary.

It’s worth noting that recent studies suggest a potential association between vardenafil and an increased risk of certain diseases such as sickle cell anemia, leukemia, and multiple myeloma.

Can you purchase Vardenafil online?

You can purchase vardenafil online, but it is advisable to only order from reputable sources. Counterfeit or contaminated vardenafil from unregulated sites and suspicious different manufacturers could be unsafe and ineffective. You also risk your financial details being stolen.

Summary

When it comes to treating erectile dysfunction (ED), vardenafil is one of the go-to medications prescribed by doctors. Sold under the brand names Levitra and Staxyn since it was FDA approved in 2003, vardenafil works by increasing blood flow to the penis so men can get and maintain erections when aroused. Research studies suggest that the recommended starting dose is a 10mg tablet taken by mouth about an hour before sexual activity. One dose provides improved erection capability for 4-5 hours on average, giving guys sufficient time to become intimate with their partner.

Now, emerging research suggests vardenafil may also offer some bonus benefits beyond treating ED. Small studies show it might help with symptoms of an enlarged prostate, slightly lower blood pressure, enhance exercise capacity, and even provide neuroprotective effects. However, more human studies are still needed to confirm these potential peripheral advantages of vardenafil.

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