Kisspeptin-10

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Kisspeptin-10 is a reproductive signaling peptide researched for its role in the hypothalamic-pituitary-gonadal axis, LH release, reproductive hormones, and fertility-related research.

Product Information

Kisspeptin is a naturally occurring peptide family involved in reproductive signaling. Kisspeptin-10 stimulates the release of GnRH, which subsequently influences LH and FSH secretion.

How It Works

Kisspeptin-10 activates the kisspeptin receptor and stimulates hypothalamic GnRH release. This creates downstream effects on LH, FSH and reproductive hormone signaling.

POTENTIAL BENEFITS

1. Reproductive Hormone Research

Kisspeptin-10 is extensively studied for its ability to stimulate reproductive hormone signaling, particularly LH release.

2. Testosterone Research

Human studies have shown that kisspeptin-10 can increase LH and, in certain groups, testosterone concentrations following administration.

3. Fertility Research

Because kisspeptin sits upstream of GnRH in the reproductive axis, it is an important research target for understanding reproductive dysfunction and fertility.

4. HPG-Axis Research

Kisspeptin provides researchers with a way to investigate communication between the hypothalamus, pituitary, and gonads.

5. Endocrine Research

Its ability to influence reproductive hormones makes kisspeptin-10 particularly valuable in endocrine and reproductive physiology research.

Dosage

Human research has investigated single intravenous doses including 1 mcg/kg, while other studies tested doses from approximately 0.3–10 nmol/kg depending on population and protocol. These are research-study doses, not generalized dosing recommendations.

Side Effects

Potential effects include headache, nausea, flushing, dizziness, and temporary changes in reproductive hormone levels.

References

• Pinilla L, Aguilar E, Dieguez C, Millar RP, Tena-Sempere M. Kisspeptins and reproduction: physiological roles and regulatory mechanisms. Physiological Reviews. 2012;92(3):1235-1316. PubMed
• Oakley AE, Clifton DK, Steiner RA. Kisspeptin signaling in the brain. Endocrine Reviews. 2009;30(6):713-743. PubMed

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