YK-11 (Myostine) Capsules

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YK-11 is a synthetic steroidal compound investigated for its activity at the androgen receptor and is commonly grouped within the broader SARM category. It has attracted particular interest because laboratory research has linked YK-11 to androgen-receptor activation and increased follistatin expression, creating interest in its potential role in muscle-related research.

Product Information

YK-11 is structurally distinct from many of the non-steroidal SARMs commonly discussed in research and performance circles. Laboratory studies have demonstrated that it acts as a partial agonist of the androgen receptor and produces gene-selective androgen-receptor activity.

Additional research using muscle-cell models found that YK-11 increased follistatin expression and promoted myogenic differentiation, with the researchers suggesting that follistatin induction contributes to its anabolic activity.

How It Works

YK-11 interacts with the androgen receptor and promotes its movement into the cell nucleus, where androgen-receptor signaling can influence gene expression. Research has also shown that YK-11 increases follistatin expression in muscle-cell models, providing a potential connection between androgen signaling and pathways involved in muscle differentiation.

POTENTIAL BENEFITS

1. Muscle Growth Research

YK-11 has attracted significant research interest because of its anabolic activity in laboratory models. Its androgen-receptor activity and effects on myogenic signaling make it particularly relevant to research examining mechanisms involved in muscle-cell development and lean-tissue regulation.

2. Follistatin-Related Research

One of YK-11's most distinctive characteristics is its reported influence on follistatin expression. Since follistatin is involved in regulating members of the TGF-β family, including myostatin, this pathway has become a major area of interest surrounding YK-11's potential anabolic effects.

3. Androgen Receptor Research

YK-11 provides researchers with an unusual model for studying selective androgen-receptor activity. Its partial agonist behavior and gene-selective effects distinguish it mechanistically from conventional anabolic steroids and make it useful for investigating androgen-responsive pathways.

4. Myogenic Differentiation Research

Studies in C2C12 muscle cells found that YK-11 increased expression of important myogenic regulatory factors, including MyoD, Myf5, and myogenin. These findings have contributed to interest in YK-11 for research into muscle-cell differentiation and anabolic signaling.

5. Anabolic Signaling Research

The combination of androgen-receptor activity and follistatin-related signaling gives YK-11 a particularly interesting research profile. Researchers can use these pathways to investigate how androgenic signaling interacts with muscle-growth mechanisms and regulatory proteins involved in skeletal muscle development.

Dosage

There is no established clinical human dosage for YK-11.

Online research-chemical and bodybuilding communities commonly report approximately 5–15 mg per day, although reported protocols vary considerably. These amounts are community-reported rather than medically established dosing recommendations, and there is insufficient controlled human research to establish an evidence-based dose.

Side Effects

Human safety data for YK-11 are very limited. Potential concerns associated with androgen-receptor-active compounds may include:

• Hormonal suppression
• Changes in testosterone and reproductive hormones
• Acne and oily skin
• Changes in hair growth or hair loss in susceptible individuals
• Changes in lipid profiles
• Possible liver-related effects
• Mood or libido changes

References

• Kanno Y, et al. (17α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11) is a partial agonist of the androgen receptor. Biol Pharm Bull. 2011. PMID: 21372378.PubMed
• Kanno Y, et al. Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression. Biol Pharm Bull. 2013. PMID: 23995658.PubMed

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