SR-9011 Capsules

Buy SR-9011 Online

SR-9011 is a synthetic REV-ERB agonist studied for its effects on circadian biology, cellular metabolism, inflammation, and cancer-related pathways.

Product Information

SR-9011 activates REV-ERBα and REV-ERBβ, nuclear receptors involved in the regulation of the circadian clock and metabolic gene expression. Research has explored its effects in cancer cells, metabolic pathways, and immune-cell biology.

How It Works

SR-9011 activates REV-ERB receptors, altering transcription of genes involved in circadian regulation, lipid metabolism, and cellular energy processes. This makes it useful for studying the connection between biological clocks and metabolism.

POTENTIAL BENEFITS

1. Circadian-Rhythm Research

SR-9011 directly interacts with REV-ERB proteins, which are important components of the body's molecular clock. This makes it particularly interesting for circadian biology research.

2. Metabolic Research

REV-ERB signaling regulates genes involved in metabolism, including pathways related to lipid synthesis and energy utilization.

3. Cancer Research

Experimental studies have found that SR-9011 can suppress the viability of several cancer-cell models and promote apoptosis. These findings remain preclinical.

4. Neuroinflammation Research

SR-9011 has also been studied in microglial cells, where REV-ERB signaling influences immune activity and cellular metabolism.

Dosage

There is no established human dosage for SR-9011. Online experimental protocols vary substantially and should not be interpreted as validated dosing guidance.

Side Effects

Human safety information is extremely limited. Potential concerns include altered circadian signaling, metabolic changes, and unknown long-term effects.

References

• Sato S, et al. Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence. Nature. 2018. PMID: 29320480. 29320480
• Pourcet B, et al. The Effect of Rev-erbα Agonist SR9011 on the Immune Response and Cell Metabolism of Microglia. Frontiers in Immunology. 2020. PMID: 33101272. 33101272
• Solt LA, et al. REV-ERB and ROR nuclear receptors as drug targets. Nature Reviews Drug Discovery. https://pmc.ncbi.nlm.nih.gov/articles/PMC4865262/

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