What Is AC-262,356 Liquid?

AC-262,356 (also called AC-262536 or Accadrine) is a non-steroidal selective androgen receptor modulator (SARM) supplied as a research-grade liquid solution. It is studied in vitro and in preclinical models for its partial agonist activity at the androgen receptor (AR). It is sold strictly for laboratory and research use.

Disclaimer: AC-262,356 is a research compound not approved by the U.S. Food and Drug Administration (FDA) for human or veterinary use. It is not intended to diagnose, treat, cure, or prevent any disease. This product is strictly for laboratory research purposes only.

AC-262,356 Research Background

AC-262,356 was first characterized by researchers at ACADIA Pharmaceuticals and described in a 2007 pharmacology study as a potent, tissue-selective AR ligand identified through a functional cell-based screening assay. The compound sits within the broader nonsteroidal SARM class alongside comparator molecules such as enobosarm (Ostarine), RAD140, and LGD-3303, which emerged from parallel efforts to separate androgenic and anabolic signaling in AR-targeted research, an area also explored in a 2005 Endocrinology study on SARM effects in orchidectomized rats.

How Does AC-262,356 Work? Mechanism of Action

AC-262,356 is thought to dock at the ligand-binding pocket of the androgen receptor, inducing a conformational change in the receptor's helix-12 region that allows nuclear translocation and DNA binding at androgen response elements (AREs). In binding assays, the compound has been characterized as a high-affinity AR ligand with partial agonist behavior at the receptor's transactivation domain, distinguishing it from full agonists such as testosterone or DHT. This partial, tissue-influenced activation profile is why AC-262,356 is used in research models comparing full versus partial transcriptional responses across different AR-expressing cell types.

Downstream, receptor activation by AC-262,356 has been associated in experimental models with:

• Altered gene expression profiles at androgen-responsive loci
• Modulation of protein synthesis pathways in muscle-derived cell models
• Changes in intracellular signaling cascades linked to AR transactivation

Findings on tissue selectivity are not consistent across all model systems, and the degree of AR-subtype or coregulator-dependent selectivity remains an open question in the literature.

Key Research Areas for AC-262,356

Area of Research	Research Note
AR binding & partial agonism	Characterized in a functional cell-based assay as a potent, selective AR ligand with partial agonist activity relative to testosterone.
Tissue-selectivity comparison	Investigated alongside other nonsteroidal SARMs for differential effects on muscle and bone versus reproductive tissue, an approach paralleled in orchidectomized-rat SARM research.
Comparative SARM research	Used in structure-activity relationship (SAR) work alongside reference compounds such as RAD140, enobosarm (Ostarine), and ACP-105 to probe scaffold-dependent AR selectivity.
Gene expression & transcriptional regulation	Applied in research on AR-mediated transcriptional activity and androgen response element (ARE) engagement.
Analytical & metabolic fate studies	Investigated in analytical chemistry contexts for detection, stability, and metabolic profiling in biological matrices.

Physical, Structural & Handling Properties

• Molecular formula: C₁₈H₁₈N₂O
• Molecular weight: 278.35 g/mol
• CAS number: 870888-46-3
• IUPAC name: 4-[(1R,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]naphthalene-1-carbonitrile
• Synonyms: AC-262536, AC 262, AC262, Accadrine
• Form supplied: research-grade liquid solution in a stabilizing solvent carrier, formulated for solubility, stability, and ease of volumetric measurement in laboratory settings
• Physical description: the parent compound is a naphthalenecarbonitrile-based small molecule; the liquid carrier is selected to keep the compound in solution across standard laboratory storage conditions

What Are the Risks and Limitations of AC-262,356 Research?

This section is mandatory reading before working with AC-262,356 in any laboratory setting.

• Handling Precautions: AC-262,356 should be handled by trained laboratory personnel only, in a controlled research environment. Use appropriate PPE at all times. Avoid direct skin contact or inhalation of any aliquoted solution.
• Exposure Risks: AC-262,356 is a nonsteroidal SARM thought to interact with androgen receptor signaling in preclinical models. No human safety data exist for this compound.
• Storage: Store AC-262,356 Liquid at −20 °C in a dry, dark environment, protected from light, heat, and moisture. Avoid repeated freeze-thaw cycles.
• Toxicity and Data Limitations: No chronic toxicity data exist for AC-262,356. All available findings come from short-duration preclinical and in vitro models only, and results are not consistent across all systems studied.

AC-262,356 Liquid: Frequently Asked Questions

What is AC-262,356 classified as?

AC-262,356 is classified as a non-steroidal selective androgen receptor modulator (SARM), distinct in scaffold from steroidal androgens like testosterone.

How does AC-262,356 differ from a full AR agonist like testosterone?

It is characterized in laboratory assays as a partial AR agonist, producing a smaller transcriptional response than a full agonist under the same experimental conditions.

How does AC-262,356 compare to other research SARMs like RAD140 or enobosarm?

All three are nonsteroidal AR ligands studied for tissue-selective signaling, but they differ in chemical scaffold and in their reported receptor-binding and selectivity profiles across preclinical models.

Is AC-262,356 approved for human or veterinary use?

No. It is not approved by the FDA for human or veterinary use and is sold strictly for laboratory research.

How should AC-262,356 Liquid be stored?

It should be stored at −20 °C, protected from light, heat, and moisture, and handled only by trained laboratory personnel.

What to Look for in a Supplier When Sourcing Research-Grade AC-262,356 Liquid?

Check that every batch is independently third-party tested for purity and identity, and that a Certificate of Analysis (COA) is available for each lot. Prefer suppliers that sell strictly for preclinical and in-vitro research use. You can consider verified suppliers such as Behemoth Labz, where compounds are tested through an independent laboratory and sold strictly for laboratory and research use.

Note: All products referenced are strictly for LABORATORY AND RESEARCH PURPOSES ONLY. They are not to be used for any human or veterinary purposes.

Disclosure: This content is for informational purposes only and does not constitute an endorsement of any product for human use.

References

1. Piu, F., Gardell, L. R., Son, T., Schlienger, N., Lund, B. W., Schiffer, H. H., Vanover, K. E., Davis, R. E., Olsson, R., & Bradley, S. R. (2007). Pharmacological characterization of AC-262536, a novel selective androgen receptor modulator. Journal of Steroid Biochemistry and Molecular Biology, 109(1–2), 129–137. https://pubmed.ncbi.nlm.nih.gov/18164613/
2. Gao, W., Reiser, P. J., Coss, C. C., Phelps, M. A., Kearbey, J. D., Miller, D. D., & Dalton, J. T. (2005). Selective androgen receptor modulator treatment improves muscle strength and body composition and prevents bone loss in orchidectomized rats. Endocrinology, 146(11), 4887–4897. https://academic.oup.com/endo/article-abstract/146/11/4887/2500134

ATTENTION: This content is for LABORATORY AND RESEARCH PURPOSES ONLY. Not for human or veterinary use. Educational purpose only. No human consumption.

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