PE-22-28

Buy PE-22-28 Peptide Online

PE-22-28 is an experimental neuroactive peptide derived from the spadin sequence and has attracted attention for research into TREK-1 signaling, neurogenesis, synaptic activity, and antidepressant-like effects.

Product Information

PE-22-28 is a seven-amino-acid peptide developed as a shorter spadin analogue. Research has investigated its activity against the TREK-1 potassium channel.

How It Works

PE-22-28 blocks the TREK-1 potassium channel. In experimental models, this activity has been associated with changes in neuronal signaling, neurogenesis, and synaptic markers.

Potential Benefits

1. TREK-1 Research

PE-22-28 has demonstrated strong affinity for the TREK-1 channel in laboratory testing. Its selectivity makes it useful for investigating this increasingly interesting neurological target.

2. Neurogenesis Research

Animal studies have reported increased neurogenesis following treatment with PE-22-28 and related analogues. This makes it relevant to research into neuronal regeneration and plasticity.

3. Synaptic Research

Studies have reported increased PSD-95 expression in neuronal cultures. This provides an interesting avenue for studying synapse formation and neuronal communication.

4. Mood-Related Research

PE-22-28 has produced antidepressant-like effects in mouse behavioral models. Importantly, these findings remain preclinical rather than established human treatment outcomes.

Dosage

Published studies use experimental animal protocols rather than human dosing. Online peptide forums have discussed around 400 mcg intranasally once daily, but this is a community-reported protocol rather than an established clinical dose

Side Effects

A reliable human safety profile has not been established.

References

1. Djillani A, Pietri M, Moreno S, et al. Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity. Frontiers in Pharmacology. 2017;8:643. PMID: 28955242. PubMed
2. Full-text research article. PMC Full Text

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