CJC-1295 with DAC

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CJC-1295 with DAC is a long-acting growth hormone-releasing hormone (GHRH) analog studied for its ability to produce sustained increases in growth hormone and IGF-1.

Product Information

The Drug Affinity Complex (DAC) allows CJC-1295 to bind to albumin after administration, substantially extending its half-life compared with shorter-acting GHRH analogs. Human studies have demonstrated prolonged increases in GH and IGF-1.

How It Works

CJC-1295 stimulates GHRH receptors in the pituitary, increasing GH secretion. The DAC component extends the compound's circulation time, allowing GH and IGF-1 levels to remain elevated for considerably longer than with conventional short-acting GHRH analogs.

POTENTIAL BENEFITS

1. Growth-Hormone Research

Human studies have demonstrated substantial increases in circulating GH following CJC-1295 administration, making it one of the better-characterized GHRH analogs.

2. IGF-1 Research

CJC-1295 produces sustained increases in IGF-1, an important mediator of growth-hormone signaling involved in muscle, bone, and tissue physiology.

3. Prolonged GH Signaling

The DAC modification gives CJC-1295 a substantially longer half-life, allowing researchers to examine prolonged GH stimulation rather than short hormone pulses.

4. Body-Composition Research

Because GH and IGF-1 influence protein metabolism, tissue growth, and body composition, CJC-1295 has attracted interest in metabolic and body-composition research.

Dosage

Human clinical studies have investigated CJC-1295 at experimental doses including 30 and 60 mcg/kg, with other studies examining higher doses. These were controlled research protocols and should not be interpreted as a general personal dosing recommendation.

Side Effects

Reported or potential effects include injection-site reactions, headache, flushing, dizziness, and effects associated with elevated GH/IGF-1 signaling.

References

1. Teichman SL, et al. *Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.* Journal of Clinical Endocrinology & Metabolism. 2006;91(3):799-805. PMID: 16352683.

[PubMed](16352683)

2. Teichman SL, et al. *Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog.* Journal of Clinical Endocrinology & Metabolism. 2006. PMID: 17018654.

[PubMed](17018654)

3. Alba M, et al. *Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone analog, normalizes growth in the GHRH knockout mouse.* American Journal of Physiology-Endocrinology and Metabolism. 2006. PMID: 16822960.

[PubMed](16822960)

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