FOXO4-DRI

Product Details: FOXO4-DRI (Peptide)

FOXO4-DRI, also referred to as Proxofim, is a synthetic peptide made from a modified structure and a portion of the FOXO4 protein. The change lengthens the protein's half-life and allows it to interfere with normal FOXO4 function. Studies have shown that FOXO4-DRI prevents normal FOXO4 binding to p53, enabling the removal of senescent cells, improved organ function, and a younger "biological age" for the tissue. 

Mechanism of Action

In experimental systems, FOXO4-DRI may disrupt the connection between FOXO4 and p53. This disturbance may change p53's location and activity in controlled laboratory settings. Signaling pathways involved in cell cycle regulation and cellular stress responses are linked to these alterations.

Chemical Properties of FOXO4-DRI (Peptide)

• Molecular Formula: C₂₂₈H₃₈₈N₈₆O₆₄
• Molecular Weight: 5358.05 g/mol
• IUPAC Name: H-Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH
• Synonyms: Proxofim, FOXO4 D-Retro-Inverso Peptide

Research Applications of FOXO4-DRI

FOXO4-DRI is employed in controlled research that focuses on senescent cells. It may make it easier for scientists to understand how changing specific protein interactions affects cellular activity.

Some lab studies look at the relationship between this peptide and intracellular communication pathways, as well as apoptotic signaling.

The study will look at how FOXO4-DRI interacts with pathways associated to oxidative stress and cellular regulation. The current findings are still insufficient and require further research.

Why Buy FOXO4-DRI from BehemothLabz

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For laboratory research involving FOXO4-related pathways, this compound may be considered as part of controlled experimental work.

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References

• Baar, M. P., et al. (2017). Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. Cell, 169(1), 132–147. https://pubmed.ncbi.nlm.nih.gov/28340339/
• López-Otín, C., et al. (2013). The hallmarks of aging. Cell, 153(6), 1194–1217. https://pubmed.ncbi.nlm.nih.gov/23746838/
• Kirkland, J. L., & Tchkonia, T. (2017). Cellular senescence: A translational perspective. EBioMedicine, 21, 21–28. https://pubmed.ncbi.nlm.nih.gov/28416161/
• Zhu, Y., et al. (2015). The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell, 14(4), 644–658. https://pubmed.ncbi.nlm.nih.gov/25754370/

PubChem. (n.d.). FOXO4-DRI Peptide. National Center for Biotechnology Information.

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