Buy GHRP-2 (Growth Hormone Releasing Peptide-2) Online

Product Details: GHRP-2

What is GHRP-2?

GHRP-2 is a synthetic hexapeptide research compound. It is supplied as a lyophilized powder at a 10mg fill size.

GHRP-2 (D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys-NH2), also known by its pharmaceutical name pralmorelin, is a growth hormone secretagogue (GHS) containing unnatural D-amino acids that confer resistance to enzymatic degradation. It is approved in Japan as a diagnostic agent for growth hormone deficiency, but it is not FDA-approved for any use in the United States. In laboratory settings, it is investigated for its role in stimulating pituitary growth hormone release via the ghrelin receptor. This is a process central to the study of endocrine signaling in experimental and clinical models.

This lyophilized powder format is used in research settings to allow investigators to study ghrelin-receptor-mediated growth hormone secretagogue activity without relying on a pre-formulated diagnostic product.

Pharmacokinetic half-life: approximately 25–30 minutes based on published GH pulse kinetics data, necessitating timed dosing intervals in research designs requiring sustained GHS-R1a stimulation. 

Disclaimer: GHRP-2 is a research compound not approved by the U.S. Food and Drug Administration (FDA) for human or veterinary use. It is not intended to diagnose, treat, cure, or prevent any disease. This product is strictly for laboratory research purposes only.

ATTENTION: This product is strictly for LABORATORY AND RESEARCH PURPOSES ONLY. Not for human or veterinary use.

Mechanism of Action of GHRP-2

GHRP-2 Working in Preclinical and Clinical Models

GHRP-2 is thought to exert its effects primarily through agonism at the ghrelin receptor (GHS-R1a) on pituitary somatotroph cells. Specifically, experimental and clinical data suggest it triggers pulsatile release of growth hormone independent of the GHRH-receptor pathway used by compounds such as CJC-1295. This is thought to drive downstream increases in IGF-1 in research models.

Key mechanistic observations from laboratory studies:

• Ghrelin receptor agonism: GHRP-2 is thought to activate GHS-R1a, triggering pituitary growth hormone release.
• GHRH-independent pathway: Studies have observed GHRP-2 working through a separate mechanism from GHRH-receptor agonists, relevant to combination-research models.
• Secondary hormone effects: GHRP-2 co-stimulates ACTH and cortisol at GH-releasing concentrations in preclinical models — unlike the selective ipamorelin, which produces no ACTH/cortisol elevation at 200× ED50 (Raun et al. 1998, PMID 9849822). This adrenal co-stimulation profile is a critical experimental variable that must be controlled in any study with adrenal endpoints. 
• Validated detection methods: Analytical chemistry literature documents validated LC-MS/MS methods for detecting GHRP-2 and its metabolites in human urine, reflecting its established use in anti-doping laboratories.

Chemical Properties of GHRP-2

GHRP-2

Property	Detail
PubChem CID	6918245
Molecular Formula	C45H55N9O6
Molecular Weight	817.97 g/mol
CAS Number	158861-67-7
Sequence	D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys-NH2
Synonyms	Pralmorelin, KP-102
Purity	≥99% (HPLC verified, per batch COA)
Physical Form	White lyophilized powder
Storage	-20°C, protected from light and moisture
Classification	Research chemical in the US; approved in Japan as a GH-deficiency diagnostic (pralmorelin); not FDA-approved in the US

Research Applications of GHRP-2

1. Ghrelin Receptor Signaling Research In preclinical and clinical models, GHRP-2 has been investigated for its ghrelin receptor (GHS-R1a) agonist activity, suggesting involvement in growth hormone secretagogue research distinct from GHRH-pathway compounds.
2. Growth Hormone/IGF-1 Axis Research GHRP-2's stimulation of pulsatile GH release makes it a tool for investigating downstream IGF-1 signaling in endocrine research models.
3. Comparative Secretagogue Research GHRP-2 is used in research comparing its secondary hormone-effect profile (cortisol, prolactin) against other ghrelin-receptor agonists such as Ipamorelin and GHRP-6.
4. Analytical and Anti-Doping Detection Research Validated LC-MS/MS detection methods for GHRP-2 and its metabolites in human urine support analytical-chemistry and anti-doping laboratory research.

Risk and Handling Precautions

Risk Tier: MODERATE-HIGH

This rating reflects GHRP-2's bioactive activity at the ghrelin-receptor endocrine-signaling pathway in preclinical and clinical models, its explicit listing on the WADA Prohibited List, and the absence of FDA-approved status for any use in the United States. Researchers must observe the following precautions at all times.

Handling Precautions: GHRP-2 should be handled by trained laboratory personnel only. Use appropriate personal protective equipment (PPE) at all times, including gloves and eye protection. Avoid direct skin contact, inhalation, or accidental exposure during laboratory handling.

Exposure Risks: GHRP-2 has some human clinical data from its use and approval as pralmorelin in Japan, but no human toxicity data exists for this specific research-grade compound as sold in the US.

Storage: Store at -20°C in a dry, dark environment protected from light, heat, and moisture. Check the batch Certificate of Analysis for lot-specific guidance. Do not use if the seal has been compromised.

Toxicity and Data Limitations: No chronic toxicity data specific to this research-grade compound exist outside of its approved diagnostic use in Japan. Findings from that diagnostic-use context cannot be assumed to apply directly to this vendor-supplied research product.

Why Choose BehemothLabz for Research-Grade GHRP-2?

BehemothLabz supplies GHRP-2 for laboratory and research purposes. Every batch is independently tested by third-party laboratories for purity and identity. A Certificate of Analysis is publicly available for each lot. BehemothLabz does not self-certify.

The compound is USA-made and held to research-grade standards. It is available strictly to qualified researchers for use in controlled laboratory environments.

BehemothLabz Disclaimer

ATTENTION: All BehemothLabz products are strictly for LABORATORY AND RESEARCH PURPOSES ONLY. They are not to be used for any human or veterinary purposes.

Please make sure you go through the Terms and Conditions and familiarize yourself with them, as it is important. Kindly research the scientific uses of this product before making any purchases. Make note that the packaging and labels of the product may differ from those shown on the website.

Buying the product means you agree to our Terms and Conditions. You can contact our customer service team at support@behemothlabz.com if you are not fully satisfied with the product.

GHRP-2 Research FAQs

Is GHRP-2 banned by WADA? 

Yes, unambiguously. GHRP-2 is explicitly named on the World Anti-Doping Agency's Prohibited List under Section S2.2.4 (Growth Hormone Releasing Factors/GHRPs), prohibited at all times, in and out of competition. This is directly checkable at wada-ama.org/en/prohibited-list.

Is GHRP-2 FDA-approved? 

Not in the United States. GHRP-2 is approved in Japan as the diagnostic agent pralmorelin, for evaluating growth hormone deficiency, a fact documented in Japanese regulatory and pharmacological literature. It has no FDA approval for any use in the US, verifiable via the absence of any listing on the FDA's DailyMed database at dailymed.nlm.nih.gov.

Can I verify the chemical identity of GHRP-2 independently? 

Yes. GHRP-2 has a public PubChem entry (CID 6918245) maintained by NCBI (part of NIH), checkable directly at pubchem.ncbi.nlm.nih.gov, listing its CAS number (158861-67-7) and molecular formula (C45H55N9O6).

Is GHRP-2 part of the FDA's compounding review process affecting peptides like BPC-157? 

No. GHRP-2 is not currently part of the FDA's Pharmacy Compounding Advisory Committee (PCAC) review batch covering BPC-157, TB-500, KPV, and MOTS-c. It remains an unregulated research chemical in the US outside of any 503A pathway.

What does each vial contain? 

Each vial contains GHRP-2 as a lyophilized powder, at a 10mg total fill, with no other active ingredients.

What purity standard does BehemothLabz provide for GHRP-2? 

Every batch is independently tested by third-party laboratories. GHRP-2 is verified at ≥99% purity by HPLC analysis. A Certificate of Analysis confirming purity and molecular identity is available per lot. GHRP-2 produces greater peak GH output per unit dose than GHRP-6 in comparative preclinical models. Both co-stimulate ACTH and cortisol. GHRP-6 produces stronger orexigenic/appetite signalling via the ghrelin pathway — use GHRP-6 when appetite pathway co-activation is a secondary research variable; use GHRP-2 when maximal GHS-R1a agonist potency is the primary objective. 

How should GHRP-2 be stored? 

Store at -20°C in a dry, dark environment protected from light, heat, and moisture. Check the batch Certificate of Analysis for lot-specific guidance. Do not use it if the seal has been compromised.

References

1. National Center for Biotechnology Information (NCBI). GHRP-2 / Pralmorelin, PubChem CID 6918245. National Institutes of Health. Available at: https://pubchem.ncbi.nlm.nih.gov/compound/6918245
2. Bowers CY. Growth hormone-releasing peptide (GHRP). Cell Mol Life Sci. 1998;54(12):1316–1329. Available at: https://pubmed.ncbi.nlm.nih.gov/9893710/
3. Okano M, Sato M, Ikekita A, Kageyama S. Determination of growth hormone secretagogue pralmorelin (GHRP-2) and its metabolite in human urine by liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom. 2010;24(14):2046–2056. Available at: https://pubmed.ncbi.nlm.nih.gov/20552695/
4. World Anti-Doping Agency. The 2026 Prohibited List International Standard, Section S2.2.4. Available at: https://www.wada-ama.org/en/prohibited-list

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