Buy SNAP-8 (Acetyl Octapeptide-3)

Product Details: SNAP-8 (Acetyl Octapeptide-3)

What is SNAP-8?

SNAP-8 is a synthetic octapeptide research compound. It is supplied as a lyophilized powder, available in 10mg and 100mg fill sizes.

SNAP-8 (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2) is an elongated analogue of Argireline (Acetyl Hexapeptide-3), a peptide sequence derived from the N-terminal region of SNAP-25, a core SNARE-complex protein. SNAP-8 is INCI-listed as Acetyl Octapeptide-3, a cosmetic-formulation ingredient designation; this is separate from, and does not imply, FDA approval as a drug or finished treatment. This is commonly studied in cosmetic-formulation and neuromuscular signaling research. In preclinical and in vitro models, it is studied to assess its influence on cellular signaling pathways involved in:

• SNARE-complex competitive binding
• Neurotransmitter release regulation, and
• Muscle micro-contraction signaling

This lyophilized powder format is used in research and formulation settings to allow investigators to study peptide-protein interaction and stability without relying on a pre-formulated finished product.

Disclaimer: SNAP-8 is a research compound not approved by the U.S. Food and Drug Administration (FDA) for human or veterinary use. It is not intended to diagnose, treat, cure, or prevent any disease. This product is strictly for laboratory research and formulation purposes only.

ATTENTION: This product is strictly for LABORATORY AND RESEARCH PURPOSES ONLY. Not for human or veterinary use.

Mechanism of Action of SNAP-8

SNAP-8 Working in Preclinical Models

SNAP-8 is thought to exert its effects in preclinical and in vitro models primarily through competitive occupation of the SNARE complex. Specifically, experimental data suggest it occupies a binding position normally used by native SNAP-25, without cleaving the protein. This is thought to affect acetylcholine release and downstream muscle micro-contraction signaling at the neuromuscular junction.

Key mechanistic observations from laboratory studies:

• SNARE-complex competition: SNAP-8 is thought to competitively bind within the SNARE complex, mimicking a segment of the N-terminal SNARE motif of SNAP-25 and occupying a coiled-coil binding position normally used by the native protein. This is understood to reduce SNARE complex assembly efficiency in a concentration-dependent and reversible manner.
• Reduced acetylcholine release: Studies in in vitro settings have observed reduced acetylcholine release associated with this competitive binding.
• Non-cleaving mechanism: Unlike botulinum toxin, which cleaves SNAP-25, SNAP-8 is thought to occupy the binding site without cleaving the protein, distinguishing its mechanism.
• Structural elongation effects: In formulation studies, SNAP-8's added length relative to Argireline has been associated with altered binding affinity and stability characteristics.

Chemical Properties of SNAP-8

SNAP-8

Property	Detail
Molecular Formula	C41H70N16O16S
Molecular Weight	1,075.16 g·mol⁻¹ (1,075.2 rounded)
CAS Number	868844-74-0
PubChem CID	86080331
Sequence	Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
Purity	≥99% (HPLC verified, per batch COA)
Physical Form	White lyophilized powder
Storage	-20°C, protected from light and moisture
Classification	Research Use Only (RUO)

Available Fill Sizes

Property	Detail
10mg fill	Standard research quantities, individual testing
100mg fill	Larger-scale formulation and research batching
Format	Lyophilized powder, single vial
Origin	USA-made

Research Applications of SNAP-8

1. SNARE-Complex Binding Studies In preclinical and in vitro models, SNAP-8 has been investigated for its competitive binding affinity and occupation kinetics within the SNARE complex, suggesting involvement in neurotransmitter-release regulation research.
2. Neuromuscular Signaling Research SNAP-8's competitive occupation of the SNAP-25 binding site makes it a tool for investigating acetylcholine-release signaling and downstream muscle micro-contraction pathways in neuromuscular junction research.
3. Cosmetic Formulation and Stability Research SNAP-8 is investigated in formulation research for stability under varying pH and temperature conditions, relevant to topical cosmetic-formulation and shelf-life modeling studies.
4. Comparative Peptide Structure-Function Research SNAP-8 has been used in structure-function research comparing its elongated sequence and binding characteristics relative to its shorter parent peptide, Argireline.

Risk and Handling Precautions

Risk Tier: LOW-MODERATE

This rating reflects SNAP-8's classification as a cosmetic-formulation research ingredient rather than a systemically bioactive research peptide, the absence of established human safety profiles for use outside topical formulation research, and standard handling considerations for lyophilized peptide powders. Researchers must observe the following precautions at all times.

Handling Precautions: SNAP-8 should be handled by trained laboratory or formulation personnel only. Use appropriate personal protective equipment (PPE) at all times, including gloves and eye protection. Avoid direct skin contact, inhalation, or accidental exposure during laboratory handling.

Exposure Risks: SNAP-8 is a research and formulation compound with no established safety profile for systemic human exposure. No independent human toxicity data exists for this compound outside manufacturer-sponsored formulation studies.

Storage: Store at -20°C in a dry, dark environment protected from light, heat, and moisture. Check the batch Certificate of Analysis for lot-specific guidance. Do not use if the seal has been compromised.

Toxicity and Data Limitations: No independently published chronic toxicity data exist for SNAP-8. Most available efficacy and safety data originates from manufacturer (Lipotec) technical documentation rather than independently published clinical research.

Why Choose BehemothLabz for Research-Grade SNAP-8?

BehemothLabz supplies SNAP-8 for laboratory and research purposes. Every batch is independently tested by third-party laboratories for purity and identity. A Certificate of Analysis is publicly available for each lot. BehemothLabz does not self-certify.

The compound is USA-made and held to research-grade standards. It is available strictly to qualified researchers and formulators for use in controlled laboratory environments, in 10mg and 100mg fill sizes to suit different research and formulation needs.

BehemothLabz Disclaimer

ATTENTION: All BehemothLabz products are strictly for LABORATORY AND RESEARCH PURPOSES ONLY. They are not to be used for any human or veterinary purposes.

Please make sure you go through the Terms and Conditions and familiarize yourself with them, as it is important. Kindly research the scientific uses of this product before making any purchases. Make note that the packaging and labels of the product may differ from those shown on the website.

Buying the product means you agree to our Terms and Conditions. You can contact our customer service team at support@behemothlabz.com if you are not fully satisfied with the product.

SNAP-8 Research FAQs

Why choose the 100mg size instead of the 10mg size? 

Both sizes contain the identical compound at the same purity standard — the 100mg size is generally more cost-effective per milligram and better suited to labs or formulators mixing larger research batches, while the 10mg size fits standard research quantities or individual testing.

How does SNAP-8 differ mechanistically from Argireline? 

Argireline is a shorter, six-amino-acid peptide that SNAP-8 is structurally derived from. SNAP-8's added length has been associated in formulation research with altered binding affinity and stability relative to Argireline, though both are studied for competitive SNARE-complex occupation.

What does each vial contain? 

Each vial contains SNAP-8 (Acetyl Octapeptide-3) as a lyophilized powder, at either 10mg or 100mg total fill, with no other active ingredients.

Is SNAP-8 approved for human use? 

No. SNAP-8 is not approved by the FDA as a drug or as a finished cosmetic treatment. It is regulated as a cosmetic-formulation ingredient candidate, sold here strictly for laboratory research and formulation purposes.

Is SNAP-8 an INCI-listed ingredient? 

Yes. SNAP-8 is INCI-listed as Acetyl Octapeptide-3, a designation used in cosmetic formulation chemistry to identify ingredients. INCI listing is a naming convention, not an FDA approval or safety endorsement.

Is SNAP-8 the same as Botox? 

No. SNAP-8 competitively occupies the same SNARE-complex binding site that botulinum toxin (Botox) cleaves, but it does not cleave the protein itself. The two compounds are mechanistically related but structurally and functionally distinct.

What purity standard does BehemothLabz provide for SNAP-8? 

Every batch is independently tested by third-party laboratories. SNAP-8 is verified at ≥99% purity by HPLC analysis. A Certificate of Analysis confirming purity and molecular identity is available per lot.

How should SNAP-8 be stored? 

Store at -20°C in a dry, dark environment protected from light, heat, and moisture. Check the batch Certificate of Analysis for lot-specific guidance. Do not use it if the seal has been compromised.

References

1. Ji M, Lee HS, Kim Y, et al. Method development for acetyl octapeptide-3 analysis by liquid chromatography-tandem mass spectrometry. J Anal Sci Technol. 2020;11:34. https://doi.org/10.1186/s40543-020-00232-8
2. Blanes-Mira C, Clemente J, Jodas G, et al. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002;24(5):303–310. https://pubmed.ncbi.nlm.nih.gov/18498523/
3. National Center for Biotechnology Information. PubChem Compound Summary for CID 86080331, SNAP-8 (Acetyl Glutamyl Heptapeptide-3). https://pubchem.ncbi.nlm.nih.gov/compound/86080331

Please click here to access instructions on how to make a payment.

How to Pay