Dapoxetine

Product Details - Dapoxetine

Dapoxetine is a synthetic compound classified as a short-acting selective serotonin reuptake inhibitor (SSRI). Structurally, it is categorized as a phenylpropylamine derivative, allowing it to interact with transport proteins involved in monoamine regulation. Within controlled research environments, it is primarily examined for its role in modulating serotonergic signaling pathways at the synaptic level.

The compound is frequently referenced in studies focusing on neurotransmitter transport dynamics, particularly those involving serotonin (5-HT) reuptake inhibition and synaptic concentration shifts.

Mechanism of Action

Dapoxetine functions through the inhibition of the serotonin transporter (SERT) at the presynaptic membrane. By limiting the reuptake of serotonin (5-HT) into presynaptic neurons, the compound increases extracellular concentrations of 5-HT within the synaptic cleft.

This elevation in serotonin availability enhances interaction with multiple receptor subtypes, including 5-HT1A and 5-HT2C receptors. As a result, downstream signaling pathways associated with G-protein coupled receptor activation and intracellular second messenger systems may be modulated.

Additionally, dapoxetine’s interaction with serotonergic circuits influences neurotransmission patterns across central pathways, making it a relevant compound for examining synaptic plasticity, receptor sensitivity, and neurotransmitter turnover. Its relatively rapid association and dissociation with transporter proteins also support studies involving transient modulation of neurotransmitter systems.

Chemical Properties of Dapoxetine

Property	Value
Product Name	Dapoxetine
CAS Number	119356-77-3
Molar Mass	341.88 g/mol
Chemical Formula	C21H23NO
IUPAC Name	(1S)-N,N-Dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine

Research Applications

Serotonin Transporter Studies

Dapoxetine is commonly utilized in experimental models investigating serotonin transporter (SERT) function. Its inhibitory interaction enables detailed analysis of transporter binding kinetics, reuptake efficiency, and synaptic serotonin regulation.

Neurotransmitter Signaling Analysis

The compound is applied in studies exploring serotonergic signaling pathways. By increasing extracellular serotonin levels, it allows researchers to examine receptor activation patterns, signal transduction mechanisms, and downstream molecular responses.

Receptor Interaction Research

Dapoxetine supports investigations into receptor subtype activity, particularly involving 5-HT1A and 5-HT2C receptors. This includes examining ligand-receptor binding dynamics, receptor sensitivity, and regulatory feedback mechanisms.

Synaptic Modulation Studies

Due to its effects on neurotransmitter availability, dapoxetine is used to study synaptic modulation processes. This includes research into neurotransmitter turnover, synaptic transmission efficiency, and short-term regulatory adaptations within neural networks.

Why Choose BehemothLabz to Buy Dapoxetine for Research

BehemothLabz supplies research-grade Dapoxetine produced under controlled laboratory conditions with strict quality assurance protocols in place. Each batch undergoes detailed analytical verification to ensure consistency in molecular composition and purity.

In addition, comprehensive documentation, including laboratory testing reports and sourcing transparency, supports reproducibility across experimental applications. BehemothLabz maintains a compliance-focused approach, ensuring that all compounds are supplied exclusively for laboratory-based investigation and analytical research.

Disclaimer

Dapoxetine is intended strictly for laboratory research and analytical purposes only. It is not designed for diagnostic procedures, therapeutic applications, or any form of in vivo study.

All references to biochemical pathways, receptor interactions, and enzymatic processes are provided solely within a research context. This compound must be handled only by qualified professionals within controlled laboratory environments, in accordance with applicable regulations and safety standards.

Any use outside of these defined research conditions is strictly prohibited.

References

• Nieves Martín, M., Marín Novoa, P., & Avendaño-Coy, J. (2025). Dapoxetine combined with non-pharmacological approaches for lifelong premature ejaculation. A systematic review and meta-analysis. The journal of sexual medicine, 22(11), 1948–1957. https://doi.org/10.1093/jsxmed/qdaf238
• Wang, Y. B., Mao, Y., Wei, Q., Wu, T. X., & Dong, Q. (2010). Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 42(4), 425–432. https://pubmed.ncbi.nlm.nih.gov/20721257/

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