EPO (Erythropoietin)

Product Details: EPO (Erythropoietin)

EPO is a peptide that is of great preclinical research interest because it mimics the signaling of natural proteins. Experimental studies focus on its interaction with receptors on target cells. BehemothLabz tests every batch in an independent laboratory. It delivers products with >99% purity as determined by HPLC analysis.

In lab environments, EPO enables scalable experiments across various animal models. Its stability is valued by researchers, as it can be readily reconstituted with bacteriostatic water. BehemothLabz provides detailed handling guides to maintain research-grade quality from arrival to analysis.

Mechanism of Action

Preclinical studies indicate that EPO binds to specific receptors on cell surfaces. It stimulates erythropoietin receptor (EPOR). It is a protein that causes intracellular signaling cascades. These cascades involve JAK2-STAT pathways. Scientists monitor the gene expression variations. Fluorescent imaging is a technique used in labs to visualise these steps in real-time. This visualization confirms pathway activation in cultured cells.

PI3K-Akt and MAPK-ERK are also affected by EPO. These signaling pathways facilitate cell survival cues and cell growth in preclinical models. Researchers apply low-oxygen chambers to simulate stress and measure EPO’s role in adaptive responses in animal models.

Chemical Properties

• Synonym: Hemopoietin and hematopoietic.
• Molecular Formula: C809H1301N299O240S5
• Molecular Mass: ~ 18.2 kDa
• PubChem ID: 135210353
• Shelf-Life: 12 to 24 months when it is stored in the right way at -20 to -80 °C.

Potential Benefits or Research Applications

Researchers highlight EPO in diverse preclinical applications, such as:

Enhance Red Blood Cell Production

EPO may simulate erythroid progenitor cells in bone marrow cultures. Researchers track colony-forming units after EPO addition in preclinical models. They note a dose-dependent increase in proerythroblasts in their experimental models. EPO Supports Tissue Oxygenation Experiments

EPO preconditioning may protect cardiomyocytes from infarct damage in preclinical models. Infarct models via coronary ligation reveal smaller lesion sizes in EPO groups. These findings tie to EPO’s induction of VEGF, which promotes the formation of capillary networks.

EPO Promotes Vascular Research

Researchers use EPO in angiogenesis assays to stimulate endothelial tube formation in preclinical research. In retinal animal models, laser-induced choroidal neovascularization responds to EPO. Treated eyes display controlled vessel growth. Researchers track the outcomes through fluorescein angiography.

EPO also aids in wound healing in preclinical studies. Researchers have observed wound reduction over time, linking effects to MMP-9 upregulation in their research models.

Why Choose BehemothLabz to Buy EPO (Erythropoietin) Online?

BehemothLabz is a premier source for EPO. It offers the highest-quality products to dedicated researchers who demand top-tier reliability.

The following unique benefits are offered at BehemothLabz:

Rapid International shipping: Ships in discreet packaging using climate-controlled containers.

Expert Support: Expert support guides in terms of storage and reconstitution in laboratories.

Safe Payments: BehemothLabz accepts bitcoin, credit cards, and other payment methods, and all transactions are completely private.

Batch Transparency: BehemothLabz issues a certificate of analysis (CoA) for each vial. All products have a traceable QR code.

Bulk Options: BehemothLabz offers discounts for high-volume orders

Reach out to us at support@behemothLabz.com | (307) 429-0990.

Disclaimer: BehemothLabz products are intended exclusively for laboratory research. Researchers assume all responsibilities for compliance with local regulations.

References

1. Zhang, C., Yang, C. and Zhu, T., 2017. From erythropoietin to its peptide derivatives: smaller but stronger. Current Protein and Peptide Science, 18(12), pp.1191-1194.
2. Sergio, C.M. and Rolando, C.A., 2022. Erythropoietin regulates signaling pathways associated with neuroprotective events. Experimental brain research, 240(5), pp.1303-1315.
3. Tóthová, Z., Šemeláková, M., Solárová, Z., Tomc, J., Debeljak, N. and Solár, P., 2021. The role of PI3K/AKT and MAPK signaling pathways in erythropoietin signalization. International Journal of Molecular Sciences, 22(14), p.7682.
4. Yoo, S.J., Cho, B., Lee, D., Son, G., Lee, Y.B., Soo Han, H., Kim, E., Moon, C. and Moon, C., 2017. The erythropoietin-derived peptide MK-X and erythropoietin have neuroprotective effects against ischemic brain damage. Cell death & disease, 8(8), pp.e3003-e3003.
5. Sergio, C.M. and Rolando, C.A., 2022. Erythropoietin regulates signaling pathways associated with neuroprotective events. Experimental brain research, 240(5), pp.1303-1315.

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