FOXO4-DRI

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FOXO4-DRI is a synthetic peptide designed to interfere with the interaction between FOXO4 and p53. It has attracted attention in cellular-aging research because this interaction can help senescent cells resist apoptosis.

Product Information

FOXO4-DRI was developed as a D-retro-inverso peptide designed to mimic functional aspects of FOXO4 while improving resistance to enzymatic degradation. Preclinical research has investigated whether disrupting FOXO4-p53 interactions can selectively promote apoptosis in senescent cells.

How It Works

FOXO4-DRI is designed to compete with endogenous FOXO4 for binding to p53. Disrupting this interaction can release p53 from senescent-cell survival signaling and promote apoptosis in cells with a senescent phenotype.

POTENTIAL BENEFITS

1. Cellular Senescence Research

FOXO4-DRI is one of the better-known experimental tools for studying selective elimination of senescent cells. Its primary research value comes from investigating how senescent cells can be targeted without broadly damaging non-senescent cells.

2. Senolytic Research

Preclinical studies have examined FOXO4-DRI as a senolytic strategy. By interfering with FOXO4-p53 binding, the peptide can promote apoptosis in certain senescent cell populations.

3. Aging Biology

Cellular senescence is closely associated with age-related tissue dysfunction. FOXO4-DRI provides a research model for examining whether removal of senescent cells can influence age-associated biological processes.

4. Vascular Aging Research

More recent research has examined FOXO4-DRI in endothelial-cell senescence and identified effects involving the p53/BCL-2/caspase-3 pathway. This expands its research relevance beyond the original aging models.

Dosage

There is no established human dosage for FOXO4-DRI. Published work has primarily involved experimental cell and animal models, and research-model dosing cannot be directly translated into a validated human regimen.

Side Effects

Human safety data are not established. Because FOXO4 and p53 are fundamental regulators of cell survival and apoptosis, disrupting this pathway may have biological consequences that cannot be predicted solely from short-term preclinical findings.

References

1. Baar MP, et al. Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotherapy and aging. Cell. 2017.
2. FOXO4-DRI regulates endothelial cell senescence via the p53 signaling pathway.
3. FOXO4-DRI and senescent-cell research.

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