IGF-1 LR3 Receptor Grade

IGF-1 LR3 is a synthetic peptide analog structurally derived from insulin-like growth factor sequences, modified through amino acid substitution and extension to alter receptor interaction dynamics and resistance to enzymatic degradation.

Peptides are short amino acid chains utilized in biochemical research to study receptor-ligand interactions, intracellular signaling pathways, and molecular binding specificity. IGF-1 LR3 is specifically examined for its interaction with insulin-like growth factor receptors and its role in signaling cascade modulation at the cellular level.

The structural modification of this peptide includes an arginine substitution at position 3 and an extended amino acid sequence, which influences receptor binding affinity and reduces susceptibility to proteolytic enzymes in controlled experimental conditions.

Mechanism of Action

IGF-1 LR3 is studied for its interaction with the insulin-like growth factor 1 receptor (IGF1R), a transmembrane receptor involved in intracellular signaling cascades.

Upon receptor binding, IGF1R undergoes autophosphorylation, initiating downstream signaling pathways, including:

• Phosphoinositide 3-kinase (PI3K)/Akt pathway
• Mitogen-activated protein kinase (MAPK) pathway

These pathways are associated with intracellular signal transduction processes, including regulation of gene expression, protein translation, and cellular signaling dynamics at the molecular level.

The structural modifications of IGF-1 LR3 contribute to prolonged receptor interaction and altered binding kinetics, making it relevant in studies analyzing receptor activation, ligand affinity, and signal propagation.

Chemical Properties of IGF-1 LR3 Receptor Grade (Peptide)

Property	Value
Chemical Formula	C400H625N111O115S9
Molar Mass	9117.60 g/mol
CAS Number	946870-92-4
Synonyms	IGF-I, IGF1A, IGFI
IUPAC Name	Insulin-like growth factor-1 long arginine 3

Research Applications

Receptor Binding and Activation Studies

IGF-1 LR3 is utilized in laboratory research to examine ligand interaction with IGF1R. Studies focus on receptor binding affinity, activation kinetics, and phosphorylation mechanisms associated with receptor engagement.

Intracellular Signaling Pathway Analysis

This peptide is applied in studies investigating downstream signaling pathways, particularly PI3K/Akt and MAPK cascades. Research examines how receptor activation influences intracellular signaling networks and molecular pathway regulation.

Proteolytic Stability and Peptide Modification Research

IGF-1 LR3 is used in studies analyzing peptide stability and resistance to enzymatic degradation. Its modified structure provides a model for evaluating how amino acid substitutions impact proteolysis and peptide longevity under controlled conditions.

Structure-Activity Relationship (SAR) Studies

The compound is utilized in structure-activity relationship research to investigate how sequence modifications affect receptor interaction, binding efficiency, and signaling pathway engagement.

Why Choose BehemothLabz to Buy IGF-1 LR3

Choose Behemoth Labz to buy igf-1 peptide for sale as the site provides research-grade compounds. IGF-1 LR3 Receptor Grade (Peptide) is manufactured under controlled laboratory conditions with strict quality assurance protocols. Each batch undergoes analytical verification to ensure consistency in molecular composition and purity.

Comprehensive documentation, including laboratory testing reports and sourcing transparency, supports reproducibility in experimental settings. BehemothLabz is considered among the best IGF-1 LR3 suppliers. It maintains a compliance-focused approach, supplying compounds intended strictly for laboratory-based investigation and analytical research

Disclaimer

IGF-1 LR3 for sale is intended strictly for laboratory research and analytical purposes only. It is not intended for use in diagnostic procedures, therapeutic applications, or in vivo studies of any kind.

Any references to biochemical pathways, receptor interactions, or enzymatic processes are provided solely for informational and research-context purposes. This compound must be handled exclusively by qualified professionals in controlled laboratory environments in accordance with applicable regulations and safety guidelines.

Improper handling or use outside of controlled research settings is strictly prohibited.

References

• Bailes, J., & Soloviev, M. (2021). Insulin-Like Growth Factor-1 (IGF-1) and Its Monitoring in Medical Diagnostic and in Sports. Biomolecules, 11(2), 217. https://doi.org/10.3390/biom11020217
• White, A., Stremming, J., Brown, L. D., & Rozance, P. J. (2023). Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets. Journal of developmental origins of health and disease, 14(3), 353–361. https://doi.org/10.1017/S2040174423000090 

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