Melanotan 1 Spray

Buy Melanotan 1 Spray Online

Melanotan 1 is the name commonly associated with afamelanotide, a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH). It has been studied extensively for stimulating melanin production and increasing pigmentation, including in photodermatological research.

Product Information

Afamelanotide is designed to activate melanocortin receptors and increase eumelanin production. Unlike Melanotan II, it was developed with a stronger clinical focus on photoprotection and pigmentation disorders and has been evaluated in randomized human trials.

How It Works

Afamelanotide activates melanocortin receptors on melanocytes, stimulating melanogenesis and increasing melanin production. The resulting pigmentation can provide a degree of endogenous photoprotection by increasing the skin's melanin content.

POTENTIAL BENEFITS

1. Melanin Production Research

Afamelanotide has demonstrated measurable increases in skin pigmentation in controlled human studies. This makes it one of the more clinically studied melanocortin analogues.

2. Photoprotection Research

Research has investigated whether increased melanin production can reduce the severity of UV-related phototoxic reactions. This has been particularly relevant in erythropoietic protoporphyria and solar urticaria.

3. Pigmentation Research

Afamelanotide has been studied in disorders involving abnormal pigmentation, including vitiligo. Clinical trials have examined its use alongside narrowband UV-B phototherapy.

4. Melanocortin Research

Melanotan 1 provides a well-characterized model for studying α-MSH-related melanocortin signaling, melanocyte activity, and the relationship between pigmentation and UV response.

Dosage

Clinical studies of afamelanotide have used 16 mg subcutaneous implants, including monthly administration in some photodermatology protocols. This information relates specifically to the clinically developed implant formulation and should not be transferred to unapproved Melanotan 1 preparations. (pubmed.ncbi.nlm.nih.gov)

Side Effects

Clinical studies have reported injection/implant-site reactions, nausea, headache, fatigue, and increased pigmentation. Freckling and darkening of existing pigmented lesions can also occur as melanogenesis increases.

References

1. Harms J, et al. *Afamelanotide for Erythropoietic Protoporphyria.* N Engl J Med.
2. Grimes PE, et al. *Afamelanotide and narrowband UV-B phototherapy for the treatment of vitiligo.* JAMA Dermatol.
3. Systemic photoprotection in solar urticaria with afamelanotide.

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