Melanotan 1

Buy Melanotan 1 Online

Melanotan-1 is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH) that has been studied for its ability to stimulate melanin production. It is particularly associated with research into pigmentation and melanocortin signaling.

Product Information

Melanotan-1, also known as [Nle4-D-Phe7]-α-MSH, is a potent melanocortin peptide. Human research has demonstrated increased pigmentation following administration, while related melanocortin analogues have also been clinically investigated for pigmentation disorders.

How It Works

Melanotan-1 activates melanocortin receptors on melanocytes, stimulating the production of eumelanin. Increased eumelanin can result in darker skin pigmentation following exposure to the peptide.

Potential Benefits

1. Melanin Production

Melanotan-1 directly stimulates melanocortin pathways involved in melanin synthesis. Human studies have demonstrated measurable changes in pigmentation following administration.

2. Skin Pigmentation Research

Clinical research has shown that Melanotan-1 can produce measurable tanning effects after repeated administration. This makes it useful for studying melanocyte activity and pigmentation pathways.

3. Melanocortin Receptor Activity

The peptide provides a strong tool for investigating α-MSH-related signaling. Its effects help illustrate how melanocortin receptor activation can influence melanogenesis and pigmentation.

4. Photoprotective Research Interest

Because eumelanin absorbs and dissipates ultraviolet radiation, melanocortin signaling has been investigated for potential photoprotective applications. However, increased pigmentation should not be considered a substitute for established UV protection.

Dosage

Human research has used substantially different Melanotan-1 regimens depending on the study design. One pharmacokinetic study evaluated subcutaneous doses of approximately 0.08-0.21 mg/kg, with 0.16 mg/kg also studied by intravenous and oral routes. These historical research doses should not be interpreted as a recommended self-administration schedule.

Side Effects

Reported effects in the human study included occasional gastrointestinal upset and facial flushing. Changes in pigmentation, including increased skin darkening, were expected pharmacological effects. The long-term safety profile of non-approved Melanotan-1 use remains insufficiently established.

References

1. Ugwu SO, Blanchard J, Dorr RT, et al. Skin pigmentation and pharmacokinetics of melanotan-I in humans. Biopharmaceutics & Drug Disposition. 1997;18(3):259-269. PMID: 9113347. PubMed
2. Dorr RT, Ertl G, Levine N, et al. Increased eumelanin expression and tanning is induced by a superpotent melanotropin [Nle4-D-Phe7]-alpha-MSH in humans. Photochemistry and Photobiology. 2000. PMID: 11045725. PubMed

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