MOTS-c

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MOTS-c is a mitochondrial-derived peptide researched for metabolic health, glucose regulation, exercise adaptation, energy metabolism, and healthy-aging research.

Product Information

MOTS-c is a 16-amino-acid peptide encoded by mitochondrial DNA. Research has linked it with metabolic regulation, skeletal-muscle signaling, and cellular responses to metabolic stress.

How It Works

MOTS-c can influence the folate-AICAR-AMPK pathway, which plays an important role in energy metabolism and glucose regulation. Research also suggests that MOTS-c can move into the nucleus during metabolic stress and influence stress-response genes.

POTENTIAL BENEFITS

1. Glucose-Metabolism Research

MOTS-c has demonstrated effects on glucose metabolism and insulin sensitivity in animal research, making it an important target in metabolic studies.

2. Exercise & Performance Research

Research in mice has shown improvements in physical capacity and muscle metabolic adaptation following MOTS-c treatment.

3. Insulin-Sensitivity Research

MOTS-c has been investigated for its ability to improve insulin sensitivity and counter metabolic dysfunction in experimental models.

4. Healthy-Aging Research

Because mitochondrial function declines with age, MOTS-c has attracted substantial attention in longevity and age-related metabolic research.

5. Fat-Metabolism Research

MOTS-c interacts with pathways involved in energy balance and has been investigated for its potential influence on fat metabolism and obesity-related changes.

Dosage

There is no established clinical dosage for MOTS-c. Online peptide communities commonly report protocols ranging from approximately 2–5 mg per administration, with some discussing around 5–10 mg per week. These are anecdotal community protocols rather than validated human dosing.

Side Effects

Reported community experiences include injection-site redness, itching, welts, bruising, and temporary discomfort. Human safety data remain limited.

References

• Lee C, Zeng J, Drew BG, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism. 2015;21(3):443-454. PMID: 25738459. PubMed
• Lee C, Kim KH, Cohen P. MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radical Biology and Medicine. 2016;100:182-187. PMID: 27216708. PubMed

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