Oleoylethanolamide (OEA) 98%+ Powder

Buy Oleoylethanolamide (OEA) 98%+ Powder Online

Oleoylethanolamide (OEA) is a naturally occurring fatty-acid ethanolamide involved in appetite regulation, lipid metabolism, and energy balance. Its high-purity 98%+ form provides a concentrated source of this bioactive lipid for nutritional and metabolic research.

Product Information

OEA is produced naturally in the gastrointestinal tract and activates pathways associated with satiety and fatty-acid metabolism, including PPAR-a signaling. Human randomized trials have investigated approximately 250 mg/day, including recent research examining metabolic and intestinal effects.

How It Works

OEA interacts with PPAR-a and other lipid-sensing pathways involved in satiety, fatty-acid oxidation, and energy regulation. These actions can influence appetite and metabolic signaling without functioning as a conventional stimulant.

POTENTIAL BENEFITS

1. Supports Appetite Regulation

OEA is naturally involved in signaling satiety after meals. Its ability to influence PPAR-a and gut-brain pathways has made it a major research target for appetite and energy-balance studies.

2. Supports Metabolic Function

Human studies have examined OEA in people with obesity and metabolic dysfunction, including research showing improvements in selected lipid-related measures when combined with dietary intervention.

3. Supports Healthy Lipid Metabolism

OEA promotes signaling associated with fatty-acid utilization and lipid metabolism. This has generated interest in its potential role in body-composition and metabolic-health research.

4. Gut and Inflammation Research

A 2026 randomized controlled trial found that 250 mg/day of OEA was well tolerated and was associated with changes in beneficial gut bacteria and selected intestinal-barrier and inflammatory biomarkers in adults with obesity.

Dosage

Human trials have commonly used 250 mg/day for approximately 8-12 weeks. A 2026 randomized controlled trial likewise provided 250 mg/day of OEA for 12 weeks and reported good tolerability.

Side Effects

Clinical trials have generally reported good short-term tolerability. Possible gastrointestinal discomfort, nausea, headache, or other mild effects may occur. Long-term high-dose safety remains less established.

References

1. Payahoo L, et al. Oleoylethanolamide Supplementation Reduces Inflammation and Oxidative Stress in Obese People: A Clinical Trial. Adv Pharm Bull. 2018. PMID: 30276145. PubMed
2. Khosravi M, et al. Effects of oleoylethanolamide supplementation on atherogenic indices and hematological parameters in patients with nonalcoholic fatty liver disease. PMID: 33312933. PubMed
3. Batacan R, et al. Oleoylethanolamide supplementation enriches Akkermansia muciniphila and modulates intestinal barrier function in adults with obesity. Gut Microbes Reports. 2026. PMID: 41924306. PubMed

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