Orexin B

Product Details - Orexin B

Orexin B is a neuropeptide derived from the precursor molecule prepro-orexin, which is processed into orexin A and orexin B through enzymatic cleavage. It is naturally associated with hypothalamic signaling systems and is studied for its role in neuropeptide-receptor interactions.

In controlled laboratory environments, orexin B is utilized to investigate receptor binding behavior and intracellular signaling pathways associated with neuropeptide activity. Its defined amino acid structure allows for consistent evaluation of peptide-receptor dynamics and signal transduction mechanisms.

This compound is supplied strictly for laboratory research purposes and is not intended for consumption, medical, or diagnostic use.

Mechanism of Action

At the molecular level, orexin B is studied for its interaction with orexin receptors, particularly orexin receptor 2 (OX2R), which belongs to the G protein-coupled receptor (GPCR) family. Upon binding, the receptor-ligand complex initiates intracellular signaling cascades, including calcium ion mobilization and downstream second messenger activity.

These signaling events are analyzed in vitro to evaluate receptor activation, ligand affinity, and intracellular communication pathways. Researchers examine how orexin B influences neurotransmitter-related signaling systems through receptor-mediated mechanisms.

Additionally, orexin B is investigated for its role in modulating neuropeptide signaling networks, contributing to a broader understanding of receptor-specific activation and molecular pathway regulation under controlled experimental conditions.

Chemical Properties of Orexin B

Attribute	Details
Compound Name	Orexin B
Classification	Neuropeptide (hypocretin-2)
Molecular Formula	C123H212N44O35S
Molecular Weight	2899.3 g/mol
CAS Number	205640-91-1
PubChem CID	44404987
Synonyms	Hypocretin-2; Orexin-B
Primary Target	Orexin receptor 2 (OX2R)
Research Context	Neuropeptide signaling and receptor interaction studies
Format	Research peptide (non-consumable)
Stability	Maintained under controlled laboratory storage conditions

Research Applications

Receptor Binding Studies

Orexin B is utilized in experimental systems to evaluate ligand interaction with orexin receptors. Researchers analyze binding affinity, receptor activation, and signal initiation at the molecular level.

Intracellular Signaling Analysis

This compound is applied in studies examining GPCR-mediated signaling pathways, including calcium-dependent signaling and second messenger systems. These investigations focus on intracellular communication and pathway regulation.

Neuropeptide Interaction Research

Orexin B supports investigations into peptide-mediated signaling networks, including interactions with neurotransmitter-associated pathways. These studies contribute to a broader understanding of neuropeptide function at the molecular level.

Why Choose BehemothLabz to Buy Orexin B for Research

BehemothLabz supplies research-grade Orexin B produced under controlled laboratory conditions with strict quality assurance protocols in place. Each batch undergoes detailed analytical verification to ensure consistency in molecular composition and purity.

In addition, comprehensive documentation, including laboratory testing reports and sourcing transparency, supports reproducibility across experimental applications. BehemothLabz maintains a compliance-focused approach, ensuring that all compounds are supplied exclusively for laboratory-based investigation and analytical research.

Disclaimer

Orexin B is intended strictly for laboratory research and analytical purposes only. It is not designed for diagnostic procedures, therapeutic applications, or any form of in vivo study.

All references to biochemical pathways, receptor interactions, and enzymatic processes are provided solely within a research context. This compound must be handled only by qualified professionals within controlled laboratory environments, in accordance with applicable regulations and safety standards.

Any use outside of these defined research conditions is strictly prohibited.

References

• Ben Musa, R., Cornelius-Green, J., Zhang, H., Li, D. P., Kline, D. D., Hasser, E. M., & Cummings, K. J. (2024). Orexin Facilitates the Peripheral Chemoreflex via Corticotropin-Releasing Hormone Neurons Projecting to the Nucleus of the Solitary Tract. The Journal of neuroscience : the official journal of the Society for Neuroscience, 44(27), e2383232024. https://doi.org/10.1523/JNEUROSCI.2383-23.2024
• Imperatore, R., & Cristino, L. (2019). Role of Orexin-B/Orexin 2 receptor in myocardial protection. Clinical science (London, England : 1979), 133(7), 853–857. https://doi.org/10.1042/CS20181036

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