Osthole 98% Capsules

Osthole 98% (Capsule Form) – Product Details

Osthole, also known as 7-methoxy-8-(3-methyl-2-butenyl) coumarin, is a naturally occurring compound classified as a coumarin derivative. It can be found in certain plants and fruit, with Cnidium monnieri (commonly known as Cnidium or She Chuang Zi) and Angelica archangelica (commonly known as Angelica or Dong Quai) being the primary sources. The compound has been studied in traditional Chinese medicine for centuries due to its reputed health benefits.

Osthole 98% represents a fascinating natural compound with multifaceted potential across various therapeutic areas. As research advances, its applications in inflammation management, neuroprotection, cardiovascular health, cancer treatment, and bone health are becoming more evident. 

The production of Osthole involves multiple steps, and chemical intermediates play a crucial role in these processes. The different intermediates are typically transient compounds that undergo further reactions and transformations to ultimately yield the final product, which is Osthole in its pure and concentrated form. 

How Does Osthole Work?

Osthole 98% exhibits a diverse range of biological effects. Its mechanism of action involves intricate interactions with various molecular pathways and cellular processes. Although not all mechanisms have been fully elucidated, research has provided insights into some key ways in which Osthole 98% exerts its effects.

Osthole has the potential to interact with specific receptors on the cell surface, initiating intracellular signaling pathways. 

Additionally, Osthole can modulate enzyme activity, impacting essential cellular processes. This versatile compound also regulates gene expression, influencing protein synthesis and other molecular functions. 

Osthole’s anti-inflammatory properties are attributed to its inhibition of pro-inflammatory molecules, while its antioxidant activity neutralizes harmful free radicals, guarding against oxidative stress. 

Furthermore, it exhibits neuroprotective properties, shielding nerve cells from damage and supporting their survival. Osthole’s ability to stimulate osteoblasts and inhibit osteoclasts fosters healthy bone metabolism.

Although scientific research has provided insights into these mechanisms, further investigation is required to fully comprehend Osthole’s potential therapeutic applications. 

Chemical Properties of Osthole 98% Capsules

• CAS Number: 484-12-8
• Molar Mass: 244.28 g/mol
• Chemical Formula: C15H16O3
• IUPAC Name: 7-Methoxy-8-(3-methylbut-2-en-1-yl)chromen-2-one
• Synonyms: Osthol, Ostholin, Ostholine, Ostrodin, Ostrosin, Ostroside, Cnidilin, Khellol Glucoside 

The designation “Osthole 98%” refers to a highly concentrated form of the compound, where the extract has been refined to contain 98% pure Osthole. This purification process ensures the potency and efficacy of the compound, making it suitable and potential for various therapeutic applications.

Research Applications of Osthole 98%

Anti-Inflammatory Activity in Experimental Models

In preclinical studies, Osthole has demonstrated measurable anti-inflammatory effects. Experimental findings indicate that it may reduce the expression of pro-inflammatory mediators and signaling molecules in cell-based and animal models, making it relevant for studying inflammatory pathways.

Antioxidant Activity in Cellular Systems

Osthole has been investigated for its antioxidant properties in laboratory settings. Studies suggest it can help neutralize reactive oxygen species (ROS) and reduce oxidative stress markers in cells, supporting its use in oxidative stress–related research models.

Neuroprotective Effects in Preclinical Studies

Initial research shows that Osthole may influence neuronal cell function in experimental systems. It has been studied for its potential to support neuronal cell integrity and modulate pathways associated with neurodegeneration in in vitro and in vivo models.

Cardiovascular-Related Effects in Research Models

In experimental studies, Osthole has shown vasorelaxant effects and interactions with pathways involved in vascular function. It has also been examined for its influence on lipid metabolism and blood flow dynamics in laboratory models.

Antiproliferative Effects in Cell-Based Studies

Osthole has been explored in cancer-related research for its effects on cell proliferation. Findings from in vitro studies suggest it may induce apoptosis and influence cell cycle regulation in certain cancer cell lines, supporting further investigation in oncology research.

Effects on Bone Metabolism in Experimental Systems

Research suggests that Osthole may modulate bone-related cellular activity. Studies indicate it can influence osteoblast differentiation and inhibit osteoclast activity in laboratory models, making it of interest in bone metabolism research.

Note: Osthole (especially in purified forms such as 98%) is not an FDA-approved dietary ingredient and is generally not classified as a standard dietary supplement. While plant extracts containing osthole (e.g., from Cnidium monnieri) may be marketed as supplements, they are not approved for the treatment of any medical conditions.

DISCLAIMER

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Reference Links

Jasemi, S. V., Khazaei, H., Morovati, M. R., Joshi, T., Aneva, I. Y., Farzaei, M. H., & Echeverría, J. (2024). Phytochemicals as treatment for allergic asthma: Therapeutic effects and mechanisms of action. Phytomedicine, 122, 155149. https://doi.org/10.1016/j.phymed.2023.155149

Michał Zimecki, Jolanta Artym, Cisowski, W., Mażol, I., Maciej Włodarczyk, & Michał Glenśk. (2009). Immunomodulatory and Anti-Inflammatory Activity of Selected Osthole Derivatives. Zeitschrift Für Naturforschung C, 64(5-6), 361–368. https://doi.org/10.1515/znc-2009-5-610

Sun, M., Sun, M., & Zhang, J. (2021). Osthole: an overview of its sources, biological activities, and modification development. Medicinal Chemistry Research, 30(10), 1767–1794. https://doi.org/10.1007/s00044-021-02775-w

García-Arroyo, F. E., Gonzaga-Sánchez, G., Silva-Palacios, A., Roldán, F. J., Loredo-Mendoza, M. L., Yamnia Quetzal Alvarez-Alvarez, Jesus, Vélez, K. A., Tapia, E., Osorio-Alonso, H., Arellano-Buendía, A. S., Sánchez-Gloria, J. L., Lanaspa, M. A., Johnson, R. J., & Sánchez-Lozada, L. G. (2023). Osthole Prevents Heart Damage Induced by Diet-Induced Metabolic Syndrome: Role of Fructokinase (KHK). Antioxidants, 12(5), 1023–1023. https://doi.org/10.3390/antiox12051023

Zhang, Z., Wing Nang Leung, Li, G., Siu Cheung Kong, Tang, Y., Yin Ping Wong, & Chun Man Chan. (2017). Osthole Enhances Osteogenesis in Osteoblasts by Elevating Transcription Factor Osterix via cAMP/CREB Signaling In Vitro and In Vivo. 9(6), 588–588. https://doi.org/10.3390/nu9060588

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