Protirelin (TRH Thyrotropin)

Product Details: Protirelin (TRH Thyrotropin) Peptide

Protirelin is short for thyrotropin-releasing hormone (TRH). It is a synthetic tripeptide used in laboratory and preclinical research. It is investigated for endocrine signaling pathways. It is structurally very similar to the endogenous TRH peptide. It is being used a lot in experimental systems to study regulatory mechanisms. These are the systems linked with hypothalamic-pituitary signaling. Due to its defined structure and receptor specificity, Protirelin makes a valuable tool for seeing peptide-mediated communication and hormone regulation in controlled research environments.

Mechanism of Action

In preclinical and experimental models, Protirelin interacts with thyrotropin-releasing hormone receptors (TRH-R). This is expressed in pituitary-derived cell systems. Upon receptor binding, it activates G protein-coupled signaling pathways. This leads to modulation of intracellular second messengers and downstream transcriptional activity.

This receptor-mediated signaling cascade is used in laboratory settings to investigate regulatory feedback mechanisms, peptide-receptor interactions, and signal transduction processes associated with endocrine axis modeling in controlled experimental systems.

Properties of Protirelin (TRH Thyrotropin) Peptide:

• Molecular Formula: C16H22N6O4
  
• Molecular Weight: 362.38 g/mol
  
• CAS Number: 24305-27-9
  
• PubChem CID: 638678
  
• Synonyms: Protirelin, Thyrotropin-Releasing Hormone, TRH, Thyroliberin
  
• Peptide Class: Synthetic tripeptide (TRH analog)
  
• IUPAC Name: (2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide

Research Applications/Benefits of Protirelin (TRH Thyrotropin) Peptide

Receptor Binding and Signaling Studies
Protirelin is used in laboratory models to check TRH receptor activation, ligand binding affinity, and downstream signaling pathways.

Endocrine Axis Modeling
Applied in preclinical systems to study regulatory signaling interactions within hypothalamic-pituitary pathways under controlled experimental conditions.

Signal Transduction Research
Utilized to examine G protein-coupled receptor signaling, second messenger systems, and transcriptional responses in experimental cell models.

Neuropeptide Interaction Studies
Protirelin serves as a model compound for exploring peptide-mediated signaling interactions in neuroendocrine research systems.

Comparative Peptide Analysis
Used in laboratory studies to compare structural and functional characteristics of tripeptides and related signaling molecules in controlled environments.

Why Choose BehemothLabz to Buy Protirelin (TRH Thyrotropin) Peptide

BehemothLabz is committed to providing high-purity research peptides manufactured under strict quality control standards. Each batch of Protirelin undergoes independent third-party testing to ensure verified purity, identity, and consistency. With a strong emphasis on reliability and scientific integrity, BehemothLabz supports researchers with dependable compounds suitable for advanced laboratory and preclinical investigations.

Disclaimer: This information is for educational purposes. We do not allow the human consumption of our products. All our products are sold for laboratory and research experiments.

ATTENTION: All BehemothLabz products are strictly for LABORATORY AND RESEARCH PURPOSES ONLY. They are not to be used for any human or veterinary purposes.

References:

1. Gary KA, Sevarino KA, Yarbrough GG, Prange AJ Jr, Winokur A. “The thyrotropin-releasing hormone (TRH) hypothesis of homeostatic regulation.” PubMed. https://pubmed.ncbi.nlm.nih.gov/8382398/
2. Nillni EA. “Regulation of the hypothalamic thyrotropin releasing hormone (TRH) neuron by neuronal and peripheral inputs.” PubMed. https://pubmed.ncbi.nlm.nih.gov/14671067/

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