SS31 (Elamipretide)

SS31 (Elamipretide) – Product Details

SS31, also known as Elamipretide, is a synthetic tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) designed to selectively target the inner mitochondrial membrane. It interacts with cardiolipin, a key phospholipid that supports mitochondrial structure and function in different research subjects. 

Research indicates that Elamipretide helps stabilize mitochondrial membranes and optimize bioenergetic efficiency by enhancing electron transport chain activity and reducing oxidative stress. 

How Does SS31 Elamipretide Work?

SS31 localizes to mitochondria and interacts with cardiolipin, contributing to the stabilization of mitochondrial membranes under conditions of bioenergetic imbalance or mitochondrial perturbation. Experimental findings suggest that this interaction may:

• Enhance mitochondrial respiration and ATP synthesis.
• Reduce excessive production of reactive oxygen species (ROS).
• Improve mitochondrial membrane potential and structural stability.

However, its safety, efficacy, and pharmacokinetics in humans have not been conclusively established.

Properties of SS31 Elamipretide

• Molecular Formula: C32H49N9O5
• Synonyms: Elamipretide / Bendavia / SS-31 peptide /Arg-Dmt-Lys-Phe-NH2
• IUPAC Name: (2S)-6-amino-2-[[(2S)-2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]hexanamide;trihydrochloride
• Molecular weight: 639.8 g/mol
• CAS Number: 736992-21-5

Research Applications of SS31 (Elamipretide)

Research has focused on the effects of SS-31 (elamipretide) on mitochondrial function and energy production. In experimental models, this peptide has been shown to interact with components of the mitochondrial inner membrane, including proteins involved in ATP synthesis and transport. Studies report that SS-31 may improve mitochondrial efficiency by enhancing ADP sensitivity and supporting ATP production, which are essential processes in cellular energy metabolism. These findings highlight its relevance in research related to mitochondrial bioenergetics and age-associated mitochondrial dysfunction.

Another study has examined the role of SS-31 in oxidative stress and mitochondrial structural stability. Experimental studies indicate that SS-31 can bind to mitochondrial membranes and influence their physical properties, including lipid organization and surface charge. This interaction has been associated with reduced oxidative stress and improved mitochondrial integrity in controlled models. Such findings suggest that SS-31 is being investigated for its potential role in protecting cells from mitochondrial damage and in studying mechanisms related to cellular stress and degeneration.

Note: SS-31 (Elamipretide) is a mitochondria-targeting research peptide. It is not intended for human consumption and is available for research purposes only.

Why Choose BehemothLabz to Buy SS31 Elamipretide?

Behemoth Labz provides the SS31 peptide for sale. It is available for research purposes only. Key benefits of sourcing from BehemothLabz include:

• Comprehensive third-party lab testing.
• Detailed Certificates of Analysis (COAs) are available for every batch.
• Secure, research-grade packaging and prompt shipping.

Disclaimer

Please make sure you go through the Terms and Conditions, and please familiarize yourself with them as they are important. Please research the scientific uses of this product before making any purchases. Make note that the packaging and labels of the product may differ from those shown on the website.

Buying the product means you agree to our Terms and Conditions. You can contact our awesome customer service team at support@behemothlabz.com if you are not fully satisfied with the product. Customer satisfaction is our number one priority!

ATTENTION: All Behemoth Labz products are strictly for LABORATORY AND RESEARCH PURPOSES ONLY. They are not to be used for any human or veterinary purposes.

Reference Links

PubChem. (2024). Elamipretide. Nih.gov; PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Elamipretide

Pharaoh, G., Kamat, V., Kannan, S., Stuppard, R. S., Whitson, J., Martín-Pérez, M., Qian, W.-J., MacCoss, M. J., Villén, J., Rabinovitch, P., Campbell, M. D., Sweet, I. R., & Marcinek, D. J. (2023). The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT). GeroScience, 45(6), 3529–3548. https://doi.org/10.1007/s11357-023-00861-y

Mitchell, W., Ng, E. A., Tamucci, J. D., Boyd, K. J., Sathappa, M., Coscia, A., Pan, M., Han, X., Eddy, N. A., May, E. R., Szeto, H. H., & Alder, N. N. (2020). The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action. Journal of Biological Chemistry, 295(21), 7452–7469. https://doi.org/10.1074/jbc.ra119.012094

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