Coluracetam Powder

Buy Coluracetam Powder Online

Coluracetam is a synthetic racetam compound originally investigated for cognitive disorders and later explored in major depressive disorder with anxiety. It is particularly notable for its proposed influence on high-affinity choline uptake.

Product Information

Coluracetam, also known as MKC-231 or BCI-540, reached human clinical development, including Phase 2 research. Available evidence is considerably smaller than for established medicines, and development for its investigated psychiatric indications was discontinued.

How It Works

Coluracetam is primarily associated with modulation of the high-affinity choline uptake system. This pathway helps neurons acquire choline for acetylcholine synthesis and has therefore been investigated in relation to memory and cognitive signaling.

POTENTIAL BENEFITS

1. Cholinergic Research

Coluracetam's distinctive pharmacology centers on high-affinity choline uptake, making it particularly interesting for researchers studying acetylcholine-related neuronal function.

2. Memory Research

Preclinical research has investigated Coluracetam in models of impaired learning and memory, especially where cholinergic neuronal function is disrupted.

3. Cognitive Function

The compound has been explored as a potential cognitive enhancer, although evidence supporting cognitive benefits in healthy humans remains limited.

4. Mood-Related Research

Coluracetam progressed into clinical research for major depressive disorder with concomitant anxiety, demonstrating that its development extended beyond traditional nootropic research.

Dosage

Human clinical-development programs have included oral dosing studies, but there is no established general therapeutic dosage for Coluracetam. Experimental doses from animal studies should not be converted directly into human dosing.

Side Effects

Human safety information is limited. Potential concerns include headache, gastrointestinal effects, insomnia, agitation, or other CNS effects, while the long-term safety profile remains insufficiently characterized.

References

1. Dutta A, McKie S, Deakin JFW. Ketamine and other potential glutamate antidepressants. Psychiatry Res. 2015;225(1-2):1-13. PMID: 25467702. PubMed
2. National Center for Advancing Translational Sciences. Coluracetam. PubMed

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