Tamoxifen

Buy Tamoxifen Online

Tamoxifen is a selective estrogen receptor modulator (SERM) with a long history of clinical use in hormone-receptor-positive breast cancer. It acts differently in different tissues, blocking estrogen signaling in breast tissue while producing estrogen-like effects in some other tissues.

Product Information

Tamoxifen binds to estrogen receptors and alters estrogen-dependent gene signaling. Its tissue-selective activity has made it one of the most extensively studied SERMs in oncology and endocrine research.

Researchers have also investigated it in male reproductive endocrinology because estrogen-receptor blockade at the hypothalamus and pituitary can increase gonadotropin secretion and influence endogenous testosterone production.

How It Works

Tamoxifen competes with estrogen for estrogen receptors. In breast tissue, it predominantly blocks estrogen signaling, while in the hypothalamic-pituitary system it can reduce estrogen-mediated negative feedback, increasing LH and FSH signaling.

POTENTIAL BENEFITS

1. Breast-Cancer Research

Tamoxifen is extensively studied in estrogen-receptor-positive breast cancer and has demonstrated clinically meaningful effects on tumor response and disease progression. It remains an important reference compound in endocrine oncology.

2. Estrogen-Receptor Research

Tamoxifen is one of the classic compounds used to investigate selective estrogen-receptor modulation. Its tissue-specific effects provide researchers with an important model for understanding estrogen signaling.

3. Male Endocrine Research

Tamoxifen has been investigated for its ability to alter hypothalamic-pituitary signaling in men. By reducing estrogenic feedback, it may increase LH and FSH and consequently influence endogenous testosterone production.

4. Fertility Research

The ability of SERMs to stimulate endogenous gonadotropins has made tamoxifen relevant to research involving male reproductive function and hormonal regulation.

5. Hormonal Signaling Research

Tamoxifen's contrasting estrogen-antagonist and estrogen-agonist effects across different tissues make it particularly useful for studying the complex biology of estrogen receptors.

Dosage

Clinical breast-cancer studies have commonly used 20 mg orally once daily. A major randomized study compared tamoxifen 20 mg once daily with anastrozole 1 mg once daily.

Other uses and dosing regimens can differ.

Side Effects

Potential side effects include:

• Hot flashes
• Nausea
• Fatigue
• Mood changes
• Menstrual changes
• Increased risk of blood clots
• Rare visual disturbances
• Endometrial changes with long-term use

References

1. Bonneterre J, et al. Anastrozole is superior to tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women. PMID: 11078488. PubMed

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