7,8-Dihydroxyflavone Powder

Buy 7,8-Dihydroxyflavone Powder Online

7,8-Dihydroxyflavone (7,8-DHF) is a flavone derivative best known for its activity at the TrkB receptor, the principal receptor for brain-derived neurotrophic factor (BDNF). It has become a prominent research compound in neuroscience and neuroprotection.

Product Information

Preclinical research has shown that 7,8-DHF can activate TrkB and downstream signaling pathways associated with neuronal survival, differentiation, and synaptic plasticity. Studies have examined its effects in models of neurodegeneration, stroke, Parkinsonism, and cognitive dysfunction.

How It Works

7,8-DHF binds to and activates TrkB, mimicking certain signaling effects normally produced by BDNF. TrkB activation can influence neuronal survival, synaptic plasticity, and neurotrophic signaling.

POTENTIAL BENEFITS

1. Supports Neurotrophic Signaling

7,8-DHF directly activates TrkB-related signaling, making it particularly interesting for research into BDNF-associated neuronal function.

2. Memory and Cognitive Research

Animal studies have reported improvements in memory-related behavior following 7,8-DHF administration, supporting its investigation as a potential cognitive research tool.

3. Neuroprotective Potential

7,8-DHF has protected neurons in several experimental models, including models involving excitotoxicity, ischemic injury, and dopaminergic degeneration.

4. Synaptic Plasticity Research

TrkB activation is closely associated with synaptic remodeling and plasticity. Research has demonstrated that 7,8-DHF can promote signaling linked to synaptogenesis and neuronal maturation.

Dosage

There is no established human therapeutic dosage for 7,8-DHF. Published doses are primarily from cellular and animal experiments and should not be treated as validated human dosing.

Side Effects

Human safety data are limited. Because TrkB signaling influences numerous neuronal and cellular processes, the consequences of sustained pharmacological activation remain incompletely characterized.

References

1. Liu X, et al. Biochemical and biophysical investigation of the brain-derived neurotrophic factor mimetic 7,8-dihydroxyflavone in the binding and activation of the TrkB receptor. J Biol Chem. 2014;289(40):27571-27584. PMID: 25143381. PubMed
2. Jang SW, et al. A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc Natl Acad Sci USA. 2010;107(6):2687-2692. PMID: 20133810. PubMed
3. Liu C et al. 7,8-dihydroxyflavone protects 6-OHDA and MPTP induced dopaminergic neuron degeneration through activation of TrkB in rodents. Neurosci Lett. 2016. PMID: 27019033. PubMed

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