Adipotide is an experimental peptide-based compound that has been investigated for its potential in targeting and reducing fat tissue in the body. It was developed as a treatment for obesity and has been studied in preclinical and animal models to understand its effects on fat cells.
CAS Number: 137525-51-0
Molar Mass: 2555.22 g/mol-1
Chemical Formula: C111H204N36O28S2
IUPAC Name: Hexanediamide
Also known by Synonyms as Prohibitin-targeting peptide 1
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What is Adipotide?
Adipotide, also known as FTPP (Fat Targeted Proapoptotic Peptide), is an experimental peptide that, based on animal research, shows promise in eliminating fat cells by disrupting their blood supply. This cell death process could potentially lead to weight reduction, enhanced insulin sensitivity, and an improved body mass index.
Originally developed as a candidate for cancer therapy, Adipotide was created by American researchers with the intent of shrinking the blood vessels that supply fresh blood to cancer cells, ultimately inducing apoptosis (cell death) in those cancer cells.
However, intriguingly, research findings suggest that Adipotide might have the ability to promote fat loss by inhibiting the blood supply to fat cells. This would involve shrinking the blood vessels that deliver blood to adipose tissue. Importantly, the impact of this synthetic peptide isn’t confined to fat reduction in animals.
In fact, multiple animal studies have demonstrated that Adipotide treatment may lead to a reduction in food intake, indicating a potential decrease in appetite. Furthermore, this synthetic peptide has shown potential for inducing weight loss in obese Old World monkeys. [R]
How Does Adipotide Work?
Adipotide is thought to work by targeting and disrupting the blood supply to fat cells in animals. It does so by binding to a protein called prohibitin, which is found on the surface of blood vessels that nourish fat tissue. By binding to prohibitin, Adipotide may induce apoptosis, which is a process of programmed cell death. This, in turn, causes the blood vessels supplying fresh blood to the fat cells to shrink, depriving the fat cells of necessary nutrients and ultimately leading to their death.
As a result of this process, fat cells are eliminated, potentially leading to weight loss and improvements in composition. Additionally, the reduction in fat tissue may contribute to enhanced insulin sensitivity and a healthier body mass index (BMI) in animal research. It’s important to note that the effectiveness and safety of Adipotide in humans require further research and clinical trials.
Adipotide and Fat Reduction
Old rhesus monkeys subjected to Adipotide treatment exhibited a significant reduction in total body fat during the study, with an average fat decrease percentage of 38.7%. Moreover, their abdominal white adipose tissue volume decreased by 27% by the end of the recovery period, and these changes were statistically significant. [R]
Adipotide and Obesity
In a study involving obese mice, Adipotide administration resulted in a 30% reduction in weight over a 4-week period, while lean mice did not experience weight loss. This suggests that Adipotide may promote weight loss by targeting excess fat. [R]
Similar findings were observed in rhesus monkeys, with two treated monkeys losing 1.8 kg (5.4%) and 2.1 kg (20.4%) of body weight after nine weeks of Adipotide dosing, whereas the control group did not experience weight changes.
A study with a larger cohort of 15 obese rhesus monkeys demonstrated weight reductions ranging from -7.4% to -14.7% of their initial body weight following Adipotide treatment, further supporting the potential use of Adipotide for obesity treatment in humans.
Adipotide and Body Mass Index (BMI)
Body Mass Index is a significant indicator of health. Adipotide treatment in rhesus monkeys with BMIs ranging from 34 to 45 resulted in a dose-dependent decrease in BMI. Morbidly obese monkeys experienced a 17.1% reduction in BMI, while another treated monkey saw a 20.4% decrease.
Adipotide and Insulin Resistance
Adipotide research has indicated a substantial reduction in insulin resistance among obese monkeys. The average insulinogenic index decreased by 48.5% in monkeys treated with Adipotide, signifying a significant improvement in insulin sensitivity.
Studies on mice fed a high-fat diet demonstrated that Adipotide’s impact on fat vasculature led to improvements in insulin resistance. [R]
Adipotide and Glucose Tolerance
In a study with obese mice on a high-fat diet, Adipotide showed positive effects on glucose tolerance, as evidenced by a glucose tolerance test. The Adipotide group exhibited improved glucose tolerance compared to the control group.
Adipotide, also known as FTPP (Fat Targeted Proapoptotic Peptide), is an experimental peptide that has shown potential in animal research for reducing body fat by cutting off the blood supply to fat cells, leading to their apoptosis and potential weight loss. Originally developed for therapeutic cancer treatment by shrinking blood vessels supplying cancer cells, Adipotide has demonstrated a unique ability to reduce fat mass, induce weight loss, improve insulin resistance, and lower body mass index (BMI) in animal studies. Notably, it does not impact blood sugar levels, making it a promising avenue for obesity research and potentially contributing to healthier body composition.
Where to Buy Adipotide for Sale?
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