IGF-1 DES

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IGF-1 DES, also known as Des(1-3)IGF-I, is a truncated form of insulin-like growth factor-1. Its structural modification reduces binding to several IGF-binding proteins, giving the peptide distinctive biological characteristics.

IGF-1 DES is also written as DES(1-3)IGF-1, Des(1-3)IGF-I, or des(1-3)IGF-I in scientific literature

Product Information

Des(1-3)IGF-I lacks the first three amino acids of native IGF-1. Research has shown that this modification can increase free-peptide activity because the truncated analogue interacts differently with IGF-binding proteins.

How It Works

IGF-1 DES acts through the IGF-1 receptor while showing substantially reduced interaction with certain IGF-binding proteins. This can increase the availability of the active peptide in experimental systems.

POTENTIAL BENEFITS

1. IGF Signaling Research

IGF-1 DES is useful for investigating IGF-1 receptor activation and the downstream pathways controlling cellular growth and metabolism.

2. Muscle & Anabolic Research

IGF signaling influences protein synthesis and muscle-cell activity, making Des(1-3)IGF-I relevant to experimental muscle and tissue-growth research.

3. Cell-Growth Research

The peptide has been studied in cellular systems because altered IGF-binding behavior can produce pronounced effects on proliferation and differentiation.

4. IGF-Binding Protein Research

Its reduced affinity for several IGF-binding proteins makes IGF-1 DES a valuable experimental tool for understanding how binding proteins regulate IGF bioavailability.

Dosage

There is no established human therapeutic dosage for IGF-1 DES. Published evidence is predominantly biochemical, cellular, and preclinical, and the available research does not establish a validated human dosing protocol.

Side Effects

IGF-1 pathway manipulation can potentially affect blood glucose, tissue growth, and cell proliferation. Because IGF-1 signaling is broadly distributed, uncontrolled exposure may have effects beyond the intended research pathway.

References

1. PubMed — Des(1-3)IGF-I: a truncated form of IGF-I
2. PubMed — IGF-binding proteins and Des(1-3)IGF-I
3. PubMed — Des(1-3)IGF-I and IGF receptor biology

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