B7-33

Product Details:  B7-33 (Peptide)

B7-33 is a synthetic peptide available from BehemothLabz for use in research and labs. 

B7-33, a novel analog of the relaxin family peptides, stands out for its unique structural composition. In its design, the focus zeroed in on the B-chain, known for its involvement in high-affinity binding. The initial challenge of creating a single-chain peptide was overcome by strategically truncating the N-terminal and elongating the C-terminal of the B-chain, resulting in the soluble and active peptide known as B7-33.

This structurally refined peptide demonstrated distinct behavior in various cellular contexts. While proving to be a weak agonist in cells with RXFP1 overexpression, B7-33 showcased enhanced biological activity in rat renal myofibroblasts and primary human ventricular fibroblasts, both native RXFP1-expressing cells. Particularly noteworthy was its comparable bioactivity to H2 relaxin in inducing matrix metalloproteinase 2 expression, a pivotal collagen-degrading enzyme.

Working Mechanism

During its design, the peptide was modified to improve solubility and stability while keeping biological activity. In cell-based studies, B7-33 shows different activity depending on the receptor environment.

• Lower activity in overexpressed RXFP1 systems
• Higher functional response in native fibroblast cells

It suggests that the peptide behaves better in physiologic-like conditions rather than artificial systems. [1][2]

Chemical Properties 

• Amino Acid Sequence: Modified and shortened version of human relaxin-2
• Molecular Weight: Around 2700–3000 g/mol 
• Molecular Formula: C131H229N41O36S 
• CAS: 1818415-56-3
• Synonyms: B7-33, B7-33 peptide, RXFP1 agonist B7-33, Relaxin-2 B-chain derived peptide

Research Application 

B7-33 is used in research for the following:

– RXFP1 receptor signaling studies
– fibroblast activity and matrix interaction models
– investigation of biased agonism in GPCR systems
– experimental fibrosis-related pathways in animal models

It is mainly used where selective pathway activation is required.

Why Choose BehemothLabz

BehemothLabz is a location where quality meets trust and perfection. We not only provide RAD 150 for sale, but also guarantee the following:

- Batch-verified before release.

- First-party COA available.

- Clean synthesis process.

- Consistent material for repeated studies.

Support is available directly at support@behemothLabz.com or (307) 429-0990.

Disclaimer: This information is for educational purposes. We do not allow the human consumption of our products. All our products are sold for laboratory and research experiments.

References

[1] Hossain, M. A., Rosengren, K. J., Haugaard-Kedström, L. M., Zhang, S., Layfield, S., Ferraro, T., ... & Bathgate, R. A. D. (2016).
The minimal active structure of human relaxin-2.
Journal of Biological Chemistry, 291(7), 3341–3353.
https://doi.org/10.1074/jbc.M115.689190

[2] Samuel, C. S., Zhao, C., Bathgate, R. A. D., & Summers, R. J. (2017).
Relaxin and its receptor RXFP1: signaling and physiological roles.
Pharmacology & Therapeutics, 171, 1–20.
https://doi.org/10.1016/j.pharmthera.2016.09.002

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