Dihexa Powder

Buy Dihexa Powder Online

Dihexa is a small-molecule analog derived from angiotensin IV research and developed as a blood-brain-barrier-penetrant HGF/c-Met pathway modulator. It has attracted substantial interest because of its reported effects on synaptic formation and cognitive performance in animal models.

Product Information

Research has shown that Dihexa binds hepatocyte growth factor (HGF), enhances HGF-dependent c-Met signaling, and promotes hippocampal spinogenesis and synaptogenesis. Oral Dihexa has also demonstrated procognitive effects in animal models.

How It Works

Dihexa interacts with HGF and enhances signaling through the c-Met receptor. This pathway is involved in neuronal growth, synaptic development, and cellular repair, providing the mechanistic basis for Dihexa's cognitive research profile.

POTENTIAL BENEFITS

1. Synaptogenesis Research

Dihexa has demonstrated the ability to promote hippocampal spinogenesis and synaptogenesis in experimental systems. These effects make it particularly interesting in research focused on forming and strengthening neuronal connections.

2. Cognitive Performance Research

Orally administered Dihexa has produced procognitive effects in animal models, including improvements in spatial-learning tasks. This is one of the compound's most notable research characteristics.

3. Neuroplasticity Research

By influencing HGF/c-Met signaling, Dihexa may affect pathways involved in neuronal growth and structural plasticity. This gives it a broader research profile than compounds acting solely as acute stimulants.

4. Blood-Brain-Barrier Penetration

Dihexa was specifically developed to overcome the blood-brain-barrier limitations associated with earlier angiotensin-derived molecules, allowing it to reach central nervous system targets in experimental models.

Dosage

There is no established human dosage for Dihexa. Research doses in animal and cellular models should not be interpreted as human therapeutic dosing.

Side Effects

Human safety data are very limited. Because HGF/c-Met signaling regulates growth, differentiation, and tissue remodeling, unintended effects from sustained pathway activation remain an important research concern.

References

1. McCoy AT, et al. The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system. J Pharmacol Exp Ther. 2014;349(2):286-293. PMID: 25187433. PubMed
2. Mizuno S, Nakamura T. The Brain Hepatocyte Growth Factor/c-Met Receptor System: A New Target for the Treatment of Alzheimer's Disease. Front Pharmacol. 2015. PMID: 25649658. PubMed

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