Pregnenolone Powder

Buy Pregnenolone Powder Online

Pregnenolone is a naturally occurring steroid hormone precursor produced from cholesterol. It sits upstream of several important steroid hormones and also acts as a neurosteroid, making it particularly interesting in research involving cognition, mood, stress, and neurological function.

Product Information

Pregnenolone can be converted into progesterone, DHEA, cortisol, and other steroid hormones, while pregnenolone sulfate has independent effects on neuronal signaling. Human studies have investigated pregnenolone at doses ranging from relatively low replacement-style doses to substantially higher research doses.

How It Works

Pregnenolone serves as a precursor for multiple steroid hormones and neuroactive metabolites. These downstream compounds can influence GABAergic, glutamatergic, hormonal, and other signaling pathways throughout the body and brain.

POTENTIAL BENEFITS

1. Supports Neurosteroid Research

Pregnenolone is one of the body's central neurosteroid precursors, making it important in research into brain signaling, stress adaptation, cognition, and emotional regulation.

2. Cognitive Function Research

Clinical studies have investigated Pregnenolone as an adjunctive compound in people with psychiatric and neurological conditions. One randomized trial reported improvements in selected attention and executive-function measures with 50 mg/day.

3. Mood and Stress Research

Pregnenolone has been studied in bipolar depression, schizophrenia, substance-use disorders, and stress-related conditions. Its ability to influence downstream neurosteroids makes it particularly interesting in these areas.

4. Steroid-Hormone Precursor

As an upstream steroid precursor, Pregnenolone participates in the production of several biologically important hormones. This gives it a broader physiological role than compounds acting on a single receptor.

Dosage

Human studies have used different protocols depending on the research objective. Examples include 15-30 mg/day in healthy volunteers, 50 mg/day in several psychiatric trials, and escalating protocols reaching 500 mg/day in specific clinical research. These are study-specific doses rather than a universal recommended regimen.

Side Effects

Possible adverse effects include headache, fatigue, irritability, sleep changes, hormonal effects, and mood changes. Because Pregnenolone can alter downstream steroid hormones, prolonged or high-dose use may produce effects that differ substantially between individuals.

References

1. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OW. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology. 2004;29(4):486-500. PMID: 14749094. PubMed
2. Pinna G, et al. Adjunctive Pregnenolone Ameliorates the Cognitive Deficits in Recent-Onset Schizophrenia. Neuropsychopharmacology. 2014. PMID: 24496044. PubMed
3. Brown ES, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology. 2014;39:2867-2873. PMID: 24917198. PubMed

Note: BehemothLabz does not sell this product. Purchase links on this page may direct you to third-party suppliers through affiliate links.

Please click here to see how purchases actually work on this site.