LL-37 (CAP-18)

Buy LL-37 (CAP-18) Online

LL-37 is the active C-terminal peptide derived from human cathelicidin hCAP18. It is one of the best-studied human antimicrobial peptides and has attracted research interest for its roles in innate immunity, inflammation, cellular migration, and tissue repair. LL-37 is the active 37-amino-acid C-terminal peptide derived from the human cathelicidin precursor hCAP18.

Product Information

LL-37 is a 37-amino-acid cationic peptide produced from the hCAP18 precursor. Beyond direct antimicrobial activity, research has demonstrated effects on immune-cell recruitment, inflammatory signaling, epithelial activity, and wound-related pathways.

How It Works

LL-37 interacts with microbial membranes and several mammalian cell receptors, including formyl peptide receptors. These interactions can influence antimicrobial defense, chemotaxis, inflammatory signaling, and tissue responses.

POTENTIAL BENEFITS

1. Antimicrobial Research

LL-37 can directly interact with microbial membranes and has demonstrated activity against a broad range of microorganisms in laboratory research.

2. Innate Immunity Research

As a naturally occurring component of human host defense, LL-37 is valuable for investigating how the innate immune system responds to infection and tissue injury.

3. Wound-Healing Research

LL-37 has been associated with epithelial activation, cell migration, angiogenesis, and tissue-repair signaling, making it an important peptide in wound biology research.

4. Immune-Modulation Research

LL-37 can influence immune-cell recruitment and inflammatory mediators, providing a useful model for studying the balance between antimicrobial defense and inflammation.

Dosage

There is no established human therapeutic dosage for commercially supplied LL-37 research material. Human studies have primarily investigated endogenous LL-37 levels and biological activity rather than establishing a standardized systemic dosing protocol.

Side Effects

LL-37 is biologically active and can stimulate inflammatory pathways as well as antimicrobial responses. Research has shown that it can activate eosinophils and inflammatory mediators under certain conditions, so biological effects may vary substantially by tissue and exposure.

References

1. PubMed — LL-37 and human innate immunity
2. PubMed — LL-37 antimicrobial activity in human lung
3. PubMed — LL-37 and inflammatory signaling
4. PubMed — Human cathelicidin LL-37 review

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