MOTS-c is an endogenous mitochondrial peptide naturally synthesized within the body. It has garnered attention in preclinical investigations for its potential to support metabolic balance, enhance exercise performance, address osteoporosis, and influence insulin levels.
In cellular studies, MOTS-C has demonstrated the ability to elevate intracellular NAD+ levels, a coenzyme pivotal for DNA repair, immune system functioning, and stress response modulation. Furthermore, MOTS-c has been observed to reduce the activity of myostatin, an enzyme that restricts muscle growth.
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What is MOTS-C?
MOTS-c, also known as mitochondrial open reading frame of the 12S rRNA-c (MOTS-c), is a naturally occurring mitochondrial-derived peptide in the human body. It is known for its potential role in various physiological processes, including metabolic regulation, exercise capacity enhancement, osteoporosis improvement, and insulin level modulation. MOTS-c is produced in the mitochondria, the energy-producing organelles within cells, and it is believed to play a significant role in maintaining metabolic balance and overall health.
It has also been shown to influence intracellular NAD+ levels and reduce myostatin activity, contributing to its potential effects on DNA repair, immune function, muscle growth, and stress response. MOTS-c is available for research and laboratory purposes and is not intended for human consumption.
How Does Mots-C Work?
Myostatin Inhibition: MOTS-c demonstrates the ability to reduce myostatin levels, as evidenced by preclinical studies. These findings indicate a novel role for MOTS-c as an inhibitor of myostatin, which is a protein known to restrict muscle growth. By decreasing myostatin levels, MOTS-c may promote muscle development [R].
AMPK Activation: MOTS-c has the capacity to activate AMP-activated kinase (AMPK), a crucial cellular energy sensor. This activation triggers pathways that enhance energy production, including glucose transport and fatty acid oxidation, while simultaneously inhibiting energy-consuming pathways such as lipogenesis and protein synthesis. By regulating energy metabolism through AMPK, MOTS-c contributes to cellular energy balance [R].
Folate Cycle Suppression: MOTS-c’s influence extends to the folate cycle, an essential component of proper cellular function and metabolism. The folate cycle is closely linked to the functioning of natural killer cells, a type of immune cell responsible for combating tumor cells and virus-infected cells. MOTS-c’s suppression of the folate cycle suggests potential implications for immune system modulation [R].
AICAR Level Increase: AICAR (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside) is a naturally occurring substance in the body. Studies have indicated that AICAR has the ability to enhance insulin action, stimulate mitochondrial enzymes in skeletal muscles, and reduce intra-abdominal fat content. MOTS-c appears to increase AICAR levels, potentially contributing to improved metabolic processes and fat reduction [R].
These findings highlight the multifaceted effects of MOTS-c, which has the potential to impact muscle development, cellular energy regulation, immune response, and metabolic health. It is important to note that while these effects are supported by research, ongoing studies are necessary to further elucidate the full scope of MOTS-c’s functions and potential applications. Additionally, it is essential to emphasize that MOTS-c is intended solely for research purposes and is not intended for human consumption.
The following is a compilation of research findings related to MOTS-c. It is important to note that this information is intended for educational purposes and does not constitute medical advice. For personalized guidance on MOTS-c peptide, it is advisable to consult a qualified medical professional.
MOTS-c and Insulin Sensitivity
Insulin sensitivity, which pertains to the body’s responsiveness to insulin effects, plays a pivotal role in regulating blood sugar levels and reducing the risk of diabetes development. In a preclinical investigation, mice subjected to MOTS-c injections over a 7-day period displayed improved glucose clearance, signifying enhanced insulin sensitivity. Notably, these improvements in insulin sensitivity were observed independently of changes in body weight, underscoring the potential of MOTS-c to enhance overall insulin responsiveness [R].
MOTS-c and Obesity
A 2017 study conducted in China examined MOTS-c levels in a cohort of 40 obese children and 57 healthy males. The results revealed a significant reduction in MOTS-c levels among the obese group. Moreover, a negative correlation was observed between MOTS-c levels and obesity-related parameters, including body mass index (BMI), waist circumference, and waist-to-hip ratio. These findings suggested an inverse relationship between MOTS-c levels and markers of obesity and insulin resistance [R].
MOTS-c and Osteoporosis
Osteoporosis, characterized by diminished bone mass and structural impairment, is a prevalent skeletal condition, particularly among individuals aged 50 and older. MOTS-c has exhibited potential in addressing osteoporosis in cell-based studies. It promotes the synthesis of type I collagen in osteoblasts, which is beneficial for bone health. Additionally, MOTS-c has demonstrated the ability to mitigate bone loss induced by ovariectomy through the activation of AMPK. These findings suggest the promise of MOTS-c in countering osteoporosis [R].
MOTS-c and Longevity
Japan boasts one of the world’s highest average life expectancies, with an average of 85.03 years for both sexes. MOTS-c has been proposed as a potential contributing factor to the remarkable longevity of the Japanese population. Specific polymorphisms within the MOTS-c encoding mitochondrial DNA (mtDNA), prevalent among Northeast Asian populations, are hypothesized to play a role in promoting longevity [R].
MOTS-c and Heart Health
A clinical study involving 40 patients undergoing angiography explored the levels of circulating MOTS-c in individuals exhibiting endothelial cell dysfunction. Endothelial cells regulate essential aspects of cardiovascular health, including blood pressure regulation, plaque formation, and clotting. The study suggests the potential involvement of MOTS-c in cardiovascular disease, emphasizing its significance in heart health [R].
MOTS-c and Muscle Atrophy
In a preclinical study, MOTS-c exhibited inhibitory effects on muscle atrophy signaling pathways by reducing the activity of myostatin, an enzyme known to hinder muscle growth to facilitate easier muscle movement. These outcomes suggest that MOTS-c holds potential as a therapy for counteracting insulin-therapy-induced skeletal muscle atrophy, potentially benefiting individuals facing muscle atrophy challenges [R].
These research findings collectively shed light on the diverse potential applications of MOTS-c, spanning enhanced insulin sensitivity, obesity management, osteoporosis mitigation, implications for longevity, cardiovascular health, and combatting muscle atrophy. It is essential to underscore that MOTS-c is exclusively intended for research purposes, and its application for human consumption should be guided by further scientific exploration.
Why Buy MOTS-C From Behemoth Labz
Behemoth Labz has established itself as a reliable and reputable source for research compounds since 2014. We take pride in offering the highest-quality products that are backed by independent, third-party-issued Certificates of Analysis for identification, purity, and concentration.
Our commitment to quality extends to every aspect of our business, from same-day processing to free shipping on all orders over $100 and our satisfaction guarantee.
At Behemoth Labz, we understand the importance of having access to the best compounds for research purposes. Our team is dedicated to providing exceptional customer service and ensuring that our customers have access to the compounds they need to conduct groundbreaking research.
We also offer international shipping to our customers around the world. Our team is committed to ensuring that your order arrives after research is needed to fully understand its mechanisms of action and potential applications in the treatment of various conditions.
It is critical to purchase BPC 157 from reputable vendors such as Behemoth Labz to ensure purity and quality.
With its impressive safety profile and ability to promote healing and tissue repair, BPC 157 has the potential to revolutionize the way we approach a wide range of health issues. As such, it is an exciting area of research that continues to hold great promise for the future of medicine.
Finally, because of its ability to accelerate tissue healing, reduce inflammation, and protect against organ damage, BPC 157 is a promising peptide with potential. More research is needed to fully understand its mechanisms of action and long-term safety profile, but current studies show that it is a safe and effective supplement when used according to the recommended dosages.
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