Sermorelin + GHRP-2 Blend

Sermorelin + GHRP-2 Blend – Product Information

The Sermorelin + GHRP-2 blend contains 5 mg of Sermorelin and 5 mg of GHRP-2, yielding a total of 10 mg of active peptides.Sermorelin, a synthetic analog of growth hormone-releasing hormone (GHRH), and GHRP-2 (Growth Hormone Releasing Peptide-2), a synthetic ghrelin receptor agonist, are often investigated in combination due to their complementary mechanisms in stimulating endogenous growth hormone (GH) secretion.

Sermorelin acts on the pituitary by mimicking GHRH, thereby promoting physiological GH release. In contrast, GHRP-2 activates growth hormone secretagogue receptors (GHS-R1a), enhancing GH secretion through a separate, but synergistic, pathway.

When administered together, Sermorelin and GHRP-2 may produce a more pronounced and sustained increase in circulating GH levels compared to monotherapy with either peptide. This synergy has been the subject of preclinical and clinical interest for its potential in supporting GH axis function and exploring age-related endocrine decline.

Clinical evaluation and risk-benefit assessment are essential prior to considering the use of combined peptide therapies such as the Sermorelin and GHRP-2 formulation.

What is Sermorelin?  

• CAS Number: 86168-78-7
• Molar Mass: 3357.93 g/mol
• Chemical Formula: C149H246N44O42S
• IUPAC Name: L-Tyrosyl-L-alanyl-L-α-aspartyl-L-alanyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-asparaginyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucylglycyl-L-glutaminyl-L-leucyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-isoleucyl-L-methionyl-L-seryl-L-argininamide
• Also known by Synonyms as GRF 1–29

Sermorelin is a synthetic peptide analog of growth hormone-releasing hormone (GHRH), comprising the first 29 amino acids of the endogenous GHRH sequence. It has a molecular weight of approximately 3357.9 g/mol and a relatively short plasma half-life of 11 to 12 minutes.

Sermorelin is commonly studied for its role in stimulating endogenous growth hormone (GH) secretion via activation of GHRH receptors in the anterior pituitary. Rather than supplying exogenous GH directly, sermorelin promotes physiological GH release, offering a mechanistic approach that may be considered in cases of GH insufficiency or dysregulation.

How Does Sermorelin + GHRP-2 Blend Work?

Sermorelin exerts its effect by binding to growth hormone-releasing hormone (GHRH) receptors located on the surface of anterior pituitary cells. This receptor interaction stimulates the synthesis and secretion of endogenous growth hormone (GH) into systemic circulation.

Following GH release, one of its primary actions is to stimulate hepatic production of insulin-like growth factor 1 (IGF-1), a key downstream mediator responsible for many of GH’s anabolic and growth-regulating effects.

Elevated circulating levels of GH and IGF-1 have been investigated in research settings for their roles in regulating metabolic processes, supporting linear growth during childhood and adolescence, and maintaining endocrine homeostasis.

What is GHRP-2 (Growth Hormone-Releasing Peptide-2)?

• CAS Number: 158861-67-7
• Molar Mass: 817.992 g/mol
• Chemical Formula: C45H55N9O6
• IUPAC Name: (2S)-6-Amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-aminopropanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide
• Also known by Synonyms as Pralmorelin

Growth Hormone Releasing Peptide-2 (GHRP-2) is a synthetic hexapeptide classified within the family of growth hormone secretagogues (GHS). It stimulates endogenous growth hormone (GH) release by binding to the growth hormone secretagogue receptor (GHS-R1a) located in the pituitary and hypothalamus. This interaction results in increased circulating levels of GH and subsequently insulin-like growth factor 1 (IGF-1), primarily through hepatic stimulation.

The most commonly referenced pharmaceutical form of GHRP-2 is pralmorelin, which has been studied under its salt forms, including pralmorelin hydrochloride and pralmorelin dihydrochloride, for enhanced stability and bioavailability.

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