Buy Pinealon (EDR Peptide) Online

Product Details: Pinealon

Research Transparency Notice: All primary Pinealon preclinical data originate from the Khavinson group (St. Petersburg Institute of Bioregulation and Gerontology). Independent replication by external laboratories has not been published in peer-reviewed literature. Researchers should design studies accounting for this data-provenance limitation.

Disclaimer: Pinealon is a research compound not approved by the U.S. Food and Drug Administration (FDA) for human or veterinary use. It is not intended to diagnose, treat, cure, or prevent any disease. This product is strictly for laboratory research purposes only.

ATTENTION: This product is strictly for LABORATORY AND RESEARCH PURPOSES ONLY. Not for human or veterinary use.

What is Pinealon?

Pinealon is a synthetic ultra-short tripeptide research compound. It is supplied as a lyophilized powder, available in 5mg and 10mg fill sizes.

Pinealon (H-Glu-Asp-Arg-OH), also known as the EDR peptide, is one of several ultra-short "bioregulator" peptides originally developed by Russian researcher Vladimir Khavinson and colleagues. Despite its name, Pinealon was isolated from Cortexin, a bovine/porcine brain-cortex polypeptide extract, rather than from pineal tissue; the "pineal" designation in its name refers to proposed effects on pineal-axis and neuroendocrine signaling, not its tissue of origin. It is commonly studied in connection with central nervous system function research. In preclinical models, it is studied to assess its influence on cellular signaling pathways involved in:

• Gene-expression regulation via direct chromatin interaction
• Oxidative-stress response, and
• Neuroprotective and apoptosis-regulation signaling

This lyophilized powder format is used in research settings as a delivery method that allows investigators to study peptide uptake and cellular distribution without relying on a pre-formulated finished product.

Mechanism of Action of Pinealon

Pinealon Working in Preclinical Models

Pinealon is thought to exert its effects in preclinical models primarily through direct cell and nuclear membrane penetration, given its unusually small size of only three amino acids. Specifically, experimental data from the originating research group suggest it interacts with DNA and histone proteins to influence gene expression, rather than acting through a surface receptor. This is thought to affect neuronal function, oxidative-stress response, and apoptosis-regulation signaling in research models.

Key mechanistic observations from laboratory studies:

• Direct chromatin interaction: Pinealon is thought to enter the cell nucleus without requiring a surface receptor, distinguishing its mechanism from most research peptides.
• Gene-expression modulation: Studies from the originating research group have observed changes in expression of genes tied to neuronal function and stress response.
• ROS suppression and ERK 1/2 modulation: In cerebellar granule cell models, Pinealon has been reported to reduce reactive-oxygen-species (ROS) accumulation and to suppress excess ERK 1/2 activation in a dose-dependent manner, alongside increased cell viability (Khavinson et al., Rejuvenation Research, 2011, PMID 21978084).
• Antioxidant enzyme expression: The same research program has reported associated increases in expression of antioxidant enzymes including SOD2 (superoxide dismutase 2) and GPX1 (glutathione peroxidase 1) in treated neural tissue. This finding, like the others in this section, comes from the originating research group and has not been independently confirmed.
• Neuroprotective signaling: In rodent models, Pinealon has been associated with neuroprotective activity in hyperhomocysteinemia and diabetes-related cognitive-decline research.
• Independent replication limitations: This proposed mechanism is largely specific to the originating research group and has not been broadly independently replicated outside that network.

Chemical Properties of Pinealon

Pinealon

Property	Detail
Molecular Formula	C15H26N6O8
Molecular Weight	418.41 g·mol⁻¹
CAS Number	175175-23-2
PubChem CID	10273502
Sequence	H-Glu-Asp-Arg-OH
Purity	≥99% (HPLC verified, per batch COA)
Physical Form	White lyophilized powder
Storage	-20°C, protected from light and moisture
Classification	Research Use Only (RUO)

Available Fill Sizes

Property	Detail
5mg fill	Standard research quantities, single-session use
10mg fill	Multi-session research use, larger batch dosing
Format	Lyophilized powder, single vial
Origin	USA-made

Research Applications of Pinealon

1. Gene-Expression and Chromatin Interaction Research In preclinical models, Pinealon has been investigated for its potential to interact directly with DNA and histone proteins, suggesting involvement in gene-expression regulation processes distinct from receptor-mediated peptides.
2. Neuroprotective Signaling Studies Pinealon's proposed role in oxidative-stress and apoptosis-regulation pathways makes it a tool for investigating neuroprotective signaling in rodent models of cognitive decline and hyperhomocysteinemia.
3. Comparative Bioregulator Peptide Research Pinealon is used in structure-function research alongside other ultra-short bioregulator peptides developed by the same originating research group, relevant to comparative mechanism studies.
4. Cellular Uptake Mechanism Research Pinealon's unusually small size (three amino acids) is investigated as a model for studying non-receptor-mediated cellular and nuclear uptake pathways.

Risk and Handling Precautions

Risk Tier: LOW-MODERATE

This rating reflects Pinealon's proposed bioactive gene-expression mechanism in preclinical models, the limited independent replication of its research base outside the originating research group, and the absence of established human safety profiles. Researchers must observe the following precautions at all times.

Handling Precautions: Pinealon should be handled by trained laboratory personnel only. Use appropriate personal protective equipment (PPE) at all times, including gloves and eye protection. Avoid direct skin contact, inhalation, or accidental exposure during laboratory handling.

Exposure Risks: Pinealon is a research compound with no approved safety profile for human exposure. No independent human toxicity data exists for this compound outside the originating research group's publications.

Storage: Store at -20°C in a dry, dark environment protected from light, heat, and moisture. Check the batch Certificate of Analysis for lot-specific guidance. Do not use if the seal has been compromised.

Toxicity and Data Limitations: No independently published chronic toxicity data exist for Pinealon. Most available research originates from one Russian research group and its collaborators, with limited independent replication.

Why Choose BehemothLabz for Research-Grade Pinealon?

BehemothLabz supplies Pinealon for laboratory and research purposes. Every batch is independently tested by third-party laboratories for purity and identity. A Certificate of Analysis is publicly available for each lot. BehemothLabz does not self-certify.

The compound is USA-made and held to research-grade standards. It is available strictly to qualified researchers for use in controlled laboratory environments, in 5mg and 10mg fill sizes to suit different research needs.

BehemothLabz Disclaimer

ATTENTION: All BehemothLabz products are strictly for LABORATORY AND RESEARCH PURPOSES ONLY. They are not to be used for any human or veterinary purposes.

Please make sure you go through the Terms and Conditions and familiarize yourself with them, as it is important. Kindly research the scientific uses of this product before making any purchases. Make note that the packaging and labels of the product may differ from those shown on the website.

Buying the product means you agree to our Terms and Conditions. You can contact our customer service team at support@behemothlabz.com if you are not fully satisfied with the product.

Pinealon Research FAQs

Why choose the 10mg size instead of the 5mg size? 

Both sizes contain the identical compound at the same purity standard; the 10mg size simply provides twice the quantity per vial, useful for researchers running multiple sessions without reordering as often.

How does Pinealon's mechanism differ from most research peptides? 

Most research peptides act by binding a surface receptor. Pinealon is proposed to be small enough to enter cells and the nucleus directly, interacting with DNA and histone proteins to influence gene expression instead.

How does Pinealon differ from Epitalon? 

Epitalon (Ala-Glu-Asp-Gly) is a tetrapeptide from the same Khavinson bioregulator class, derived from the pineal-gland extract Epithalamin and proposed to act on pineal/circadian biology via telomerase activation. Pinealon (Glu-Asp-Arg) is a tripeptide isolated from Cortexin, a brain-cortex extract, and is proposed to act on neuronal chromatin and oxidative-stress pathways in cortical tissue. Both share single-group origin, but sequence, source tissue, and proposed mechanism differ.

What does each vial contain? 

Each vial contains Pinealon as a lyophilized powder, at either 5mg or 10mg total fill, with no other active ingredients.

Is Pinealon approved for human use? 

No. Pinealon is not approved by the FDA for human or veterinary use. It is sold strictly for laboratory research purposes.

Is the research behind Pinealon widely independently confirmed? 

Not extensively. Almost all published research comes from one Russian research group (led by Vladimir Khavinson) and its collaborators. Independent labs outside that network have not widely replicated the findings. See the Research Transparency Notice above.

What purity standard does BehemothLabz provide for Pinealon? 

Every batch is independently tested by third-party laboratories. Pinealon is verified at ≥99% purity by HPLC analysis. A Certificate of Analysis confirming purity and molecular identity is available per lot.

How should Pinealon be stored? 

Store at -20°C in a dry, dark environment protected from light, heat, and moisture. Check the batch Certificate of Analysis for lot-specific guidance. Do not use it if the seal has been compromised.

References

1. Khavinson V, Linkova N, Kozhevnikova E, Trofimova S. EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer's Disease. Molecules. 2021;26(1):159. https://pmc.ncbi.nlm.nih.gov/articles/PMC7795577/
2. Arutjunyan A, Kozina L, Stvolinskiy S, Bulygina Y, Mashkina A, Khavinson V. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia. Int J Clin Exp Med. 2012;5(2):179–185. https://pubmed.ncbi.nlm.nih.gov/22567179/
3. Khavinson V, Ribakova Y, Kulebiakin K, Vladychenskaya E, Kozina L, Arutjunyan A, et al. Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes. Rejuvenation Research. 2011;14(5):535–541. https://pubmed.ncbi.nlm.nih.gov/21978084/

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