Clomiphene

Product Details - Clomiphene

Clomiphene is a nonsteroidal selective estrogen receptor modulator (SERM) belonging to the triphenylethylene class of compounds. The compound exists as a mixture of geometric isomers (enclomiphene and zuclomiphene), each demonstrating distinct receptor binding characteristics. Clomiphene is frequently applied in in vitro studies to evaluate receptor-ligand interactions and transcriptional regulation mediated by nuclear hormone receptors.

Mechanism of Action

Clomiphene acts as a competitive modulator of estrogen receptors (ERα and ERβ), binding to the ligand-binding domain and altering receptor conformation. This conformational shift influences the recruitment of transcriptional cofactors, resulting in modulation of estrogen-responsive gene expression.

In preclinical models, clomiphene exhibits mixed agonist-antagonist activity depending on cellular context, cofactor availability, and receptor subtype distribution. The presence of its stereoisomers contributes to differential signaling outcomes in research models, making it a valuable compound for studying selective receptor modulation mechanisms.

Properties

• Molecular Formula: C26H28ClNO
• Molecular Weight: 405.96 g/mol 
• CAS Number: 911-45-5
• PubChem CID: 2800
• Synonyms: Clomifene, Clomid, Serophene, Chloramiphene

Research Applications

Clomiphene is widely used in investigational research focused on estrogen receptor signaling, endocrine pathway regulation, and selective receptor modulation.

Applications in in vitro and experimental models include:

• Evaluation of ligand-receptor binding affinity and selectivity for ER subtypes
• Investigation of transcriptional activation and repression via estrogen response elements (EREs)
• Study of stereoisomer-specific activity in nuclear receptor signaling pathways
• Comparative analysis of SERM compounds in preclinical models
• Exploration of hypothalamic-pituitary-gonadal (HPG) axis signaling mechanisms at the molecular level

Why Choose BehemothLabz to Buy Clomiphene

Choose BehemothLabz for research-focused quality and consistency. Our Clomiphene are manufactured to meet rigorous standards suitable for laboratory and experimental use.

Each batch undergoes third-party testing to verify purity, composition, and consistency. This ensures that researchers receive a product aligned with strict analytical requirements.

We offer secure ordering systems and reliable shipping options for both domestic and international customers. Our processes are designed to maintain confidentiality and protect customer data at every stage.

With BehemothLabz, you are selecting a product developed to support precision and reliability in research environments.

Disclaimer: This information is for educational purposes. We do not allow the human consumption of our products. All our products are sold for laboratory and research experiments. 

References: 

• Legro, R. S., Barnhart, H. X., Schlaff, W. D., Carr, B. R., Diamond, M. P., Carson, S. A., Steinkampf, M. P., Coutifaris, C., McGovern, P. G., Cataldo, N. A., Gosman, G. G., Nestler, J. E., Giudice, L. C., Leppert, P. C., & Myers, E. R. (2007). Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome. New England Journal of Medicine, 356(6), 551–566. https://doi.org/10.1056/nejmoa063971
• Garcia, J., Jones, G. S., & Wentz, A. C. (1977). The use of clomiphene citrate. Fertility and Sterility, 28(7), 707–717. https://doi.org/10.1016/s0015-0282(16)42670-1

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