Protirelin (TRH Thyrotropin) (Peptide) – Product Details

Protirelin (TRH Thyrotropin), is a synthetic tripeptide hormone. It is mostly found in the hypothalamus of subjects. Various studies have shown that it has the potential to influence the endocrine system, particularly the thyroid gland and the pituitary gland in subjects. TRH thyrotropin may influence the production of thyroid hormones (T3 and T4) from the thyroid gland of test subjects. These two hormones then play a very crucial role in various functions of the subjects’ bodies. These potential roles may include effective mood enhancement, fatigue management, mental health improvement, and energy metabolism. 

Additionally, it may also be used to treat a variety of neurological disorders, including intractable epilepsy in research participants. Besides the potential benefits, Protirelin has also been widely studied as a diagnosing agent and treatment option for thyroid diseases and disorders, notably hyperthyroidism. 

How Does Protirelin Work?

According to preclinical studies, Protirelin works by influencing the two most important glands: the thyroid gland and the pituitary gland. Stimulating these glands may enhance the secretion of the Thyroid Stimulating Hormone (TSH). TSH, in return, signals the thyroid gland of subjects to increase the production of thyroid hormones. The released thyroid hormones then perform various roles in the subject’s body. Researchers can then measure how well the anterior pituitary gland works by measuring the amount of TSH released in the blood after the research subject encounters Protirelin.

Properties of Protirelin 

• Molecular Formula: C16H22N6O4
• Synonyms: Thyroliberin, TRH, Thyrotropin-releasing Hormone
• IUPAC Name: (2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxo pyrrolidine-2-carboxamide
• Molecular Weight: 362.38 g/mol
• CAS Number: 24305-27-9
• PubChem CID: 638678

Potential Benefits of Protirelin 

The potential benefits of Protirelin shown by various preclinical studies are:

• Mood Enhancement:

Research has suggested that Protirelin (TRH Thyrotropin) may influence neurotransmitter systems such as Dopamine and Serotonin, which play an essential role in mood regulation. Some preclinical studies have shown that the administration of TRH may decrease the symptoms of depression, possibly by reducing anxiety and enhancing mood. [1]

• Mental Health: 

Protirelin has neurotransmitter properties that may be used as a potential treatment for certain neuropsychiatric conditions, particularly depression and cognitive disorders. Research studies have also shown that it may be used to treat a variety of neurological disorders, including intractable epilepsy. [1]

• Fatigue Management:

Research studies have shown that Protirelin (TRH Thyrotropin) plays a key role in regulating thyroid functions, energy levels, and metabolism. It may help relieve fatigue and boost energy levels, particularly in the case of chronic fatigue syndrome and hyperthyroidism. Protirelin may enhance overall energy levels by enhancing thyroid functions. [2]

• Energy Metabolism: 

Preclinical studies have shown that Protirelin may increase energy production and metabolism by influencing the hypothalamic-pituitary-thyroid axis that affects thyroid hormone secretion. It may enhance the subject’s basal metabolic rate by increasing thyroid hormone production. This potential benefit of protirelin may help break down fats and carbohydrates to provide the body with a steady energy source. [3]

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Frequently Asked Questions (FAQs)

What is protirelin used for?

Protirelin is generally used to study its potential benefits, such as mood enhancement, mental health improvement, fatigue management, and energy metabolism. It may also be used as a diagnostic agent for thyroid diseases and disorders like mild hyperthyroidism or hypothyroidism. 

What is the best place to buy Protirelin online?

The best place to buy Protirelin online is Behemoth Labz. It offers Protirelin for sale at an affordable price that always shows optimal results in research investigations.

What are the side effects of the thyrotropin-releasing hormone?

Some of the side effects shown by the thyrotropin-releasing hormone in preclinical studies include dizziness, dry mouth, headache, frequent urination, tightness in the throat, and allergic reactions. However, these side effects may vary depending on dosage, frequency, and the subject’s health condition. 

What makes Protirelin unique?

Generally, the neurotransmitter properties make Protirelin unique. Due to these properties, it has been shown to treat various neurological disorders, such as intractable epilepsy. 

Can Protirelin improve the mood and focus of subjects?

Yes, Protirelin has shown potential benefits in improving the mood and focus of subjects; however, more research and studies are needed to understand its effects in these areas fully. 

Is Protirelin safe? 

Yes, Protirelin is generally considered safe for research studies. However, its human consumption is not approved. 

What is the shelf life of Protirelin?

The shelf life of Protirelin is generally 24 months when stored properly. However, its shelf life depends on form and storage conditions. For example, the lyophilized (powder) form can last up to 1 year when stored below 18°C. Its reconstituted solution can last for several months when stored below -18°C with the addition of a carrier protein such as 0.1% HSA or BSA.

References 

1. Marangell, Lauren B., et al. “Effects of intrathecal thyrotropin-releasing hormone (protirelin) in refractory depressed patients.” Archives of General Psychiatry 54.3 (1997): 214-222.
2. Kirkegaard, Carsten, et al. “Protirelin stimulation test and thyroid function during treatment of depression.” Archives of General Psychiatry 32.9 (1975): 1115-1118.
3. Garbutt, James C., et al. “Dose-response studies with protirelin.” Archives of General Psychiatry 51.11 (1994): 875-883.

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