AICAR (Acadesine) – Product Details

AICAR is a peptide that has recently surfaced on to the research scene due to its prowess in stimulating AMPK activity in animal studies regarding skeletal muscles. The increase in AMPK activity, as a result, potentially leads to fat oxidation and energy production.

AICAR is essentially a molecule that stands for 5-Aminoimidazole 4-carboxamide 1 ribonucleotide. The compound has gained immense popularity in biochemistry and medical research due to its potential effects on cellular metabolism and its possible applications in various health-related areas through its interaction with stem cells.

BehemothLabz sells AICAR for laboratory research use only.

• CAS Number is stated as 2627-69-2
• Molar Mass is 258.23 g/mol
• It has a Chemical Formula of C9H14N4O5
• IUPAC Name is (1R)-1-(5-Amino-4-carbamoyl-1H-imidazol-1-yl)-1,4-anhydro-D-ribitol 5-(dihydrogen phosphate)

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What is AICAR?

The AICAR peptide analog of adenosine monophosphate (AMP) has made real headlines in cell biology. This stem cells-permeable nucleotide has been found capable of stimulating AMPK activity by affecting the cell cycles which has not only made AICAR potentially the best performance-enhancing research compound but is also known to have the potential to increase fatty acid oxidation, hence potentially inducing weight reduction as per recent animal studies.

Multiple studies have been conducted to investigate the potential effects of AICAR (5-Aminoimidazole 4-carboxamide 1 ribonucleotide). In one such study, it inhibited cholesterol synthesis in liver stem cells. An animal study involving healthy subjects has found that it may increase glucose uptake in skeletal muscle cells {R}.

In mice, administration of this led to improved cognition and motor coordination. A separate study found that AICAR inhibits cancer cell proliferation by different mechanisms. Lastly, in an animal model of myocardial infarction, it improved scar formation in the heart {R}.

Out of its various benefits, it

• May have the potential to enhance insulin sensitivity{R}
• May potentially aid weight loss research {R}
• Provides potential benefits for Cardiovascular research {R}

How does AICAR Work?

AICAR activates AMPK cells including acadesine. Resultantly, Acadesine induces apoptosis of B-CLL cells in a dose-dependent manner. AICAR potentially works in the following manner:

Energy Control Center: The substance activates AMP-activated protein kinase (AMPK) in cells. This potential activation of AMPK stimulates glucose uptake and fatty acid oxidation, mimicking the effects of physical activity. Essentially, AICAR works by promoting cellular energy production and metabolism. {R} 

AICAR as a Signal: When AICAR is introduced into animal cells, this AMPK activator acts like a trigger to activate AMPK hence increasing energy levels. {R} 

Potential to influence Energy Production: All the above starts a chain reaction of AMP-activated protein kinase inside cellular biology as per animal research. This chain reaction helps cells make more energy by breaking down sugar and fat. {R} 

AICAR Research

Cell Viability Assay and Doubling Time

AICAR has been one of the most researched pharmacological modulators for AMPK activity. The majority of early studies on the role of AMPK or activating AMPK, both in the physiological regulation of metabolic pathways in cancer pathogenesis, were based solely on the use of AICAR in rat hepatocytes to activate AMPK in eukaryotic cells. Even with more complex models of AMPK down-regulation and knockout being introduced, AICAr remained a regular starting point for many studies focusing on AMPK biology. AICAR has shown beneficial effects for the treatment of diseases related to metabolism, hypoxia, exercise, nucleotide synthesis, and cancer-causing cells {R}.

AICAR and Diabetes Treatment

In healthy and diabetic mice, AICAR has shown promising results in treating Type 2 diabetes. As discussed earlier, AICAR activates acadesine. In return, acadesine induces apoptosis in animal cells (adenosine kinase), thus enhancing lipid metabolism and hepatic fatty acid oxidation. An animal study on insulin resistance in cells provides evidence that AICAR acts to prevent and treat type-2 diabetes, that too, in lower concentrations. The study demonstrates a reduction of glucose production and an improvement in glucose level regulation in diabetic subjects with air-treated cells. {R} Increased Insulin Sensitivity In rodent studies, adipose tissue (the connective tissue that stores energy as fat) inflammation may be reduced by both high and low levels of AICAR.

AICAR and Cognitive Skills Research 

Ongoing research on AICAR for cognitive enhancement holds the promise of unveiling new possibilities and breakthroughs in potential brain cell treatment in the years to come. Results obtained from various neural stem cells of an animal study of isolated hepatocytes show that it improves cognition and motor coordination in young and aged mice. Furthermore, genes relevant to neuronal development and plasticity were enriched following AICAR administration. {R} 

AICAR and Heart Health

AICAR demonstrated its remarkable potential when it successfully facilitated the healing of a heart scar in a rodent experiment. A rat study was conducted to determine whether it stimulates myocardial glycogenolysis, decreases oxidative stress, and abrogates placental ischemia-induced hypertension.

In a rodent model of reperfused MI, it improved scar formation in the aged heart. This was accompanied by enhanced collagen deposition and collagen fiber maturation in the heart. These findings show a potential therapeutic strategy to prevent adverse remodeling in the aging heart and cardiovascular disease. {R}

AICAR and Cancer Treatment 

Perhaps the biggest benefit the world is waiting for is the potential of AICAR in potential treatment of cancer cells and associated cell lines. One animal study investigated the effects of this substance in the treatment of tumor growth in osteosarcoma, both in specific methods in vitro and in vivo. The findings in this study strongly suggest that it could be considered a potential therapeutic agent for treating osteosarcoma.

Another study substantiated the effects of this regulatory-associated protein on thyroid cancer. It noted that it reduces the growth of thyroid cancer cells, invasion, and metastasis. {R}

AICAR and Stamina / Exercise Physiology

AICAR has been shown to improve endurance and exercise stamina in a rat skeletal muscle study. This could be valuable in enhancing physical performance research.

AICAR and Sperm Motility

Sperm motility is the ability of sperm to move fluently through the female reproductive tract for better fertility chances. Poor sperm motility is one of the various factors responsible for male factor infertility. Studies in chickens have shown signs of improving motion characteristics and fertilizing ability of cryo-preserved sperm, to the control. {R}
Lastly, treatment of various metabolic disorders is also known to be another potential massive benefit of this supplement.

AICAR FAQs

What is AMPK?

AMP-activated protein kinase is an evolutionary enzyme best known for sensing conserved fuel in all mammalian b cells. Exercise enhances learning and memory in animals and humans alike. As the benefits of running on brain function have not been examined to the extent to which we would like, it is unknown whether AMP-kinase (AMPK) activation in muscle can predict the enhancement of brain plasticity. However, scientists do know that, during exercise, AMPK is activated in skeletal muscle in humans, and rodents such as mice, thereby increasing the AMP/ATP ratio {R}. 

Is AICAR Legal?

The legal status of AICAR (5-aminoimidazole 4 carboxamide 1 ribonucleotide) varies by country and jurisdiction. In many countries, AICAR is not approved for clinical use or over-the-counter sale as it is primarily used for research purposes. However, it may be available for purchase from research chemical suppliers for laboratory or scientific research purposes.

Further research is needed to fully understand its mechanisms and assess its safety and efficacy in humans in terms of AICAR treatment. Moreover, the World Anti-Doping Agency and FDA are yet to approve the drug in sports.

Where to Buy AICAR for Sale?

BehemothLabz is the best place to buy AICAR online.

We have been around since 2014, supplying the highest-quality research compounds money can buy. Our products come with a 100% satisfaction guarantee, free shipping, and great customer service. We carry AICAR peptides in liquid and powder forms.

Summary

AICAR has lately become a very popular talking point for researchers as it has shown anabolic effects on skeletal muscles (through osteogenic differentiation) and fat oxidation. Some of the various benefits that make AICAR a product of future interest are its potential provision of insulin sensitivity, weight loss promotion potentially better cardiovascular health, and endurance enhancement.

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Variation	50mg