Alarelin Acetate
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Alarelin Acetate – Product Details
Alarelin Acetate peptide is a synthetic luteinizing hormone-releasing hormone (LHRH) agonist. As the acetate form of the hypothalamic peptide LHRH, Alarelin Acetate is a synthetic polypeptide that works as a gonadotropin-releasing hormone (GnRH) agonist to stimulate the pituitary gland for secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). With the correct molecular formula and molecular weight of 789.95 g/mol, this synthetic LH-RH agonist peptide may be used for laboratory research applications involving molecular mass determination, carrier protein interactions, and effects on gonadotropin secretion. Proper handling is necessary to prevent freeze-thaw cycles and maintain the integrity of the powder which is for laboratory research use only.
- CAS Number: 79561-22-1
- Molar Mass: 789.95 g/mol
- Chemical Formula: C46H63N13O12
- IUPAC Name: 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-3-(2-naphthyl)-D-alanyl-L-arginyl-L-prolyl glycyl-NH2 acetate
- Synonyms: Acetate Salt of LHRH, LHRH Acetate, Ac-ser-tyr-d-Nal(2)-arg-pro-gly-NH2 acetate, Gonadorelin Acetate, Luliberin Acetate, GNRH1 Acetate
What is Alarelin Acetate?
As mentioned above, Alarelin acetate is a synthetic gonadotropin-releasing hormone (GnRH) agonist peptide used to potentially stimulate the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
Alarelin acetate has the molecular formula of C56H78N16O12 x C2H4O2 and a molecular mass of 1167.3 Dalton. The peptide chain consists of 9 amino acids and has no glycosylation.
In the body, the hypothalamus produces GnRH, which signals the pituitary gland to secrete LH and FSH. These reproductive hormones then act on the ovaries and testes to stimulate sex steroid hormone production and regulate fertility.
As an agonist peptide, Alarelin acetate mimics natural GnRH to provoke the pituitary response. Studies measuring gonadotropin secretion in rat models have found Alarelin to have hundreds of times more biological activity than native GnRH.
This potent stimulation makes Alarelin acetate a candidate to induce ovulation and for other applications related to reproductive health. The synthetic peptide offers enhanced bioactivity compared to the body’s own GnRH to more powerfully promote pituitary signaling and downstream functions.
Possible Uses of Alarelin Acetate Peptide
Exploring mechanisms of reproductive endocrinology
Alarelin Acetate may be used in animal models to explore the potential hypothalamic regulation of gonadotropin-releasing hormone (GnRH) and its downstream effects on luteinizing hormone (LH), follicle-stimulating hormone (FSH), and sex steroid secretion. The acute and chronic effects of this GnRH agonist provide insights into hormone pulsatility, receptor regulation, and impacts on puberty, ovulation, and spermatogenesis. [R]
Alarelin Acetate can be used in animal models to study how reproduction is controlled by hormones. It works by targeting the body’s natural GnRH pathway that releases other reproductive hormones like LH and FSH. [R]
By giving Alarelin Acetate to animal models and measuring how LH, FSH, and sex hormone levels change over time, scientists may map out the intricate hormone regulation of sexual development and fertility cycles. [R]
Fertility research
In vitro administration of Alarelin Acetate potentially stimulates LH and FSH release from cultured pituitary cells of various animal models, allowing investigations into reproductive endocrine responses. In vivo, animal model studies also enable analyses of resulting ovulation, spermatogenesis, and fertility outcomes from Alarelin Acetate treatment alone or with other fertility regulating agents. [R]
Many different techniques, including the use of hormones like Alarelin Acetate, are being researched to try to improve fertility and reproductive outcomes. Alarelin Acetate has the potential to work on the body’s natural reproduction-controlling pathway that uses gonadotropin-releasing hormone (GnRH). [R]
Giving Alarelin Acetate appears to have the potential to act on GnRH targets not only in the brain but also in tissues like the spinal cord. This may induce ovulation or boost progesterone levels to better support pregnancy. [R]
Studies in live female animal models enable evaluation of whether Alarelin Acetate alone or with other fertility-focused agents may generate ovulation, sperm production, and ultimately greater fertility. [R]
Modeling Delayed Female Puberty
Rodent models using chronic prepubertal administration of Alarelin Acetate potentially display postponed vaginal opening and disrupted estrous cyclicity. This may produce scientific models to study normal versus delayed female pubertal transition and associated metabolic and skeletal effects. [R]
Alarelin acetate may be used in female rat models to create an animal model that possibly simulates delayed puberty in young women. This may help scientists study how postponing puberty affects things like reproduction, bone health, metabolism, and overall well-being later in life. [R]
Delaying puberty with Alarelin acetate may impact the intricate hormonal changes that normally happen at puberty. By interfering with these processes in rats, researchers may get insight into the complex interplay between the reproductive system, metabolic regulation, and skeletal development. [R]
The animal models of delayed puberty from Alarelin acetate are useful not just for understanding reproductive biology. They also further our knowledge of how delaying sexual maturation may impact long-term health outcomes like risk of osteoporosis, metabolic disorders, and fertility issues. [R]
How Does Alarelin Acetate Work?
Alarelin is a synthetic form of the hypothalamic peptide hormone called gonadotropin-releasing hormone (GnRH). When given as Alarelin Acetate, this polypeptide has the potential to act as a GnRH agonist by binding to receptors on cells in the pituitary gland. This triggers the pituitary gland to secrete extra amounts of other hormones called follicle-stimulating hormone (FSH) and luteinizing hormone (LH). FSH and LH then have the potential to act on the ovaries or testes to stimulate functions like the production of estrogen and testosterone steroidal hormones important for ovulation, sperm production, and sexual maturation.
Multiple lab studies in rat models have shown that Alarelin Acetate may stimulate these reproductive hormones when given as injections or infusions, demonstrating its ability to modify gonadotropin secretion through pituitary gland activation. While sometimes used in ovulation induction tests, Alarelin Acetate is currently only approved for research use to investigate the mechanisms behind hypothalamic control of reproductive endocrine pathways.
Safety and Side Effects
As a research peptide for in vitro laboratory use, there is limited data on the safety and side effects of Alarelin Acetate administration in test subjects. Results from animal models indicate acute injection may cause a transient increase in blood luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels followed by subsequent downregulation of pituitary responsiveness with chronic high doses. Theoretical possible side effects would involve other symptoms related to disruption of normal reproductive hormone signaling such as hot flashes, menstrual irregularities, reduced sperm production, or sexual dysfunction but more research is required. Proper experimental controls, safety protocols, and personal protective equipment should be used when handling to prevent contamination or unintended biological impacts.[R]
Frequently Asked Questions
What is Alarelin Acetate used for?
Alarelin Acetate is used as a research peptide to study and modulate gonadotrophin-releasing hormone (GnRH) effects on reproductive hormones like luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion.
Is Alarelin Acetate a prescription compound?
No, Alarelin Acetate is not an approved prescription compound. It is currently only authorized for scientific laboratory research use.
What effects does Alarelin Acetate potentially have on hormones?
Alarelin Acetate acts as a GnRH agonist, initially stimulating the synthesis and episodic release of LH and FSH from the pituitary gland. Chronic high doses can then downregulate these hormone receptors.
Are there any side effects of Alarelin Acetate treatment in subjects?
In animal models, documented effects are based on the acute rise and chronic fall in reproductive hormones like LH, FSH, and sex steroids. Side effects may include signs of hormone withdrawal but human data is limited. Proper experimental controls should evaluate any adverse events.
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Summary
Alarelin Acetate is a synthetic GnRH agonist that has been studied for its ability to possibly treat endometriosis. In rat studies, it has demonstrated the ability to potentially stimulate gonadotropin secretion from rat hypophyseal stimulation as well as gastric acid secretion. Alarelin Acetate has shown positive results in the ovulation induction test and appears to have the correct molecular weight to serve as an effective GnRH agonist. As a form of hypothalamic peptide, Alarelin Acetate can be stored desiccated below -18°C. and dissolved in other aqueous solutions for therapeutic use. Researchers are also exploring potential applications in food additives.
Through its mechanisms of action, Alarelin Acetate has exhibited potential benefits for potentially treating hormonal conditions like endometriosis, regulating ovulation, and modulating gastric acid secretion. While larger-scale studies in human test subjects are still needed, the early research shows promise. Alarelin’s synthetic properties also allow it to be reliably reproduced at the proper concentrations for further testing and development as a therapeutic compound.
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Strength | 5mg |
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