RAD 140 Testolone (Liquid Form) – Product Details

RAD 140, also known as Testolone, is a selective androgen receptor modulator (SARM). Animal research has shown that it could potentially increase lean muscle mass, offer neuroprotective benefits, and inhibit the growth of certain types of breast cancer cells.

RAD 140 was initially developed as a potential treatment for osteoporosis. It is currently being investigated as a potential androgen replacement therapy. RAD 140 has also undergone a phase 1 clinical trial as a possible treatment for breast cancer.

Behemoth Labz sells RAD 140 for laboratory research use only.

We also carry RAD 140 capsules if you’re looking for those instead.

• CAS Number is stated as 1182367-47-0
• Molar Mass is 393.83 g·mol−1
• It has a Chemical Formula of C20H16ClN5O2
• IUPAC Name is 2-chloro-4-{[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino}-3-methylbenzonitrile

Keep contents sealed and stored in a cool dry place. Items are shipped in a plain envelope or bubble mailer within 24-48 hours (or the next business day)

What is RAD 140?

RAD 140 is a novel, non-steroidal SARM. SARMs are a class of chemicals that may selectively bind androgen receptors (ARs) in the bone and muscle tissue. Their tissue-selective action distinguishes SARMs from conventional anabolic compounds, which bind ARs throughout the body.

Like most selective androgen receptor modulators, RAD 140 exhibits less than complete efficacy on the prostate and seminal vesicles. This is significant. Most severe side effects of anabolic compounds may come from their activation of ARs in prostate and seminal vesicles. [R]

In a cell-based study, RAD 140 showed potential for preventing AR/ER+ breast cancer growth by blocking estrogen. It could potentially do this by suppressing ESR1, the gene responsible for creating estrogen receptors. These results led to a phase 1 study examining RAD 140 as a potential breast cancer treatment. [R]

An animal study found that RAD 140 possesses neuroprotective properties. This SARM was shown to provide neuroprotection in cultured rat neurons and male rat brains, an important action that is relevant to neural health and resilience to neurodegenerative diseases. [R]

• May Increase Endurance, Muscle Mass, and Strength [R]
• May Help Prevent Alzheimer’s Disease According to Study [R]
• High Binding Affinity to Skeletal Muscle Androgen Receptors [R]

How does RAD 140 Work?

RAD 140 could potentially mimic the activity of testosterone in the body. It may do this by binding androgen receptors in the skeletal muscle. Animal studies have shown that RAD 140 is potentially fully anabolic on muscle but exhibit less than complete efficacy on the prostate and seminal vesicles. [R][R]

Research has shown that RAD 140 is potency selective, which means that it may potentially stimulate muscle weight increases at a lower dose than that required to produce prostate weight increases. Furthermore, studies involving rats and monkeys show its pre-clinical profile is very good.

Still, while Testolone RAD 140 holds great promise as a potential testosterone replacement therapy, more human studies are needed to verify its safety and efficacy for humans.

 

RAD 140 Research

Multiple animal and cell-based studies have been conducted on RAD 140. This research chemical has also been the subject of clinical research. All these pieces of research have shown that RAD 140 can potentially increase muscle mass, prevent breast cancer growth and offer neuroprotection.

However, in the absence of randomized, large-scale, placebo-controlled trials, the FDA is yet to approve RAD 140 for human consumption. Therefore, Behemoth Labz sells RAD 140 for laboratory and research purposes, not for human use.

 

RAD 140 and Muscle Mass

An animal study investigated the effects of RAD 140 treatment on cynomolgus monkeys. This study achieved a mean weight gain of greater than 10% in just four weeks of RAD 140 dosing. Mean weight gain is a crucial marker of any drug’s anabolic (muscle-building) action. [R]

Furthermore, it appeared that most of the mass increase was due to lean mass increase, even though none of the tissue weight increases were statistically significant. All in all, in the study under observation, muscle mass showed a qualitative trend that increased with dose.

In another animal study, RAD 140 significantly increase the weight of the levator ani, an androgen-responsive muscle. In fact, of the four groups of rats that took part in the study, the Testolone group reported the 2^nd highest increase in levator ani weight (in grams). [R]

 

RAD 140 and Breast Cancer

Estrogen receptor positive (ER+)/human epidermal growth factor receptor 2 negative (HER2-) breast cancers constitute the most common subset of breast cancer. According to an estimate, ER+/HER2- breast cancers are at least three-fourths of all breast cancers worldwide. [R]

In 2022, the results of a phase 1 study of RAD 140 in ER+/HER2- metastatic breast cancer were made public. These results show that RAD 140 possesses potential anti-tumor activity and a favorable safety profile. Preliminary evidence of RAD 140 engaging target was also found. [R]

A separate study showed that RAD 140 potentially inhibits the growth of AR/ER+ breast cancer models. This study found that RAD 140 potentially inhibits the growth of breast cancer models as a single agent and in combination with palbociclib (medicine prescribed for certain types of breast cancer). [R]

 

RAD 140 and Neuroprotection

A rat study was conducted to examine the potential ability of RAD 140 to offer neuroprotection in male rat brains and cultured rat neurons. Results from the study show that RAD 140 was as effective as testosterone in protecting brain cells against neurotoxins. [R]

RAD 140 was also neuroprotective in vivo using the rat kainite lesion model. It was found that in primary neuron cultures, RAD 140 increases cell viability against toxicity in a concentration-dependent manner. These neuroprotective effects are specific to apoptotic insults.

These novel findings establish the initial pre-clinical efficacy of RAD 140 in neuroprotective actions relative to Alzheimer’s disease and related neurodegenerative diseases.

 

RAD 140 FAQs

What is the half-life of RAD 140?

According to the above clinical study, RAD 140 has a relatively long half-life of 44.7 hours and a molecular weight of 393.83 g/mol. [R]

Does RAD 140 increase testosterone?

A 2010 study found that RAD 140 may cause testosterone suppression. All the participants who were to be administered RAD 140 were divided into three groups. It was found that Testolone potentially suppressed testosterone levels by approximately 200 – 300 ng/dL in all three groups. [R]

 

Where to Buy RAD 140 for Sale?

Behemoth Labz is the best place to buy RAD 140 online.

We have been around since 2014, supplying the highest-quality research compounds money can buy. All of our products come with a 100% satisfaction guarantee, free shipping, and great customer service. We carry RAD 140 capsules and RAD 140 liquid.

 

Summary

In animal studies, RAD 140 has demonstrated its androgenic effects. RAD-140 may also offer neuroprotection by protecting brain cells against apoptosis (cell death). Aside from that, it has exhibited its potential to prevent the growth of two breast cancer types in two separate clinical studies.

 

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Please make sure you go through the Terms and Conditions, and please familiarize yourself with it as it is important. Please research the scientific uses of this product before making any purchases. Make note that the packaging and labels of the product may differ from those shown on the website.
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