Orexin A (Peptide) – Product Details

Orexin A, alternatively referred to as hypocretin-1, is a neuropeptide pivotal in the regulation of wakefulness, arousal, and appetite. Unearthed in the latter part of the 20th century, this peptide is predominantly synthesized in the lateral hypothalamus. Its intricate interactions within the central nervous system have attracted considerable attention in the field of neuroscience. Although Orexin A has undergone a thorough investigation regarding its influence on sleep-wake cycles, it is important to emphasize that its use for human consumption is strongly discouraged.

The objective of this article is to provide educational information on the Orexin A peptide, concentrating on its definition, physiological mechanisms, and potential applications. It is crucial to emphasize that human consumption is strongly discouraged in this content.

What is Orexin A Peptide?

Orexin A was first identified in 1998 by researchers studying narcolepsy, a neurological disorder characterized by excessive daytime sleepiness. The discovery of the peptide’s involvement in the regulation of sleep-wake patterns opened new avenues for understanding and treating sleep disorders.

Orexin A is a 33-amino acid neuropeptide derived from a larger precursor, preproorexin. It is part of the orexin system, which includes Orexin B (hypocretin-2). The orexinergic system is primarily associated with the maintenance of wakefulness and the modulation of various physiological processes. [R] [R]

• CAS Number: 205010-06-6
• Molar Mass: Approximately 3564.07 g/mol
• Chemical Formula: C149H226N42O45S
• IUPAC Name: (2S)-2-[(S)-3-(1H-Imidazol-2-yl)propyl]-L-valine, (S)-1-[5-(4-Fluorophenyl)-1-(2-methylpropyl)-1H-pyrrol-3-yl]-3-(2-methylpropyl)-1,3-dihydro-2H-indol-2-one
• Synonyms: Hypocretin-1, OX-A, Orexin Hypocretin-1, Orexin-A, HCTR-1, Hypocretin-1 (human), Orexin A (human), and others.

Possible Uses of Orexin A Peptide

Wakefulness Promotion Research

Orexin A is widely acknowledged for its significant role in promoting and sustaining wakefulness, rendering it a potential target for the development of wake-promoting agents. Research indicates that Orexin A, through its actions on specific receptors in the central nervous system, may contribute to the maintenance of arousal and vigilance. Studies have explored the intricate neural pathways and signaling mechanisms involved, suggesting that modulation of Orexin A activity may hold promise in addressing conditions associated with excessive daytime sleepiness. [R]

Appetite Regulation Research

Scientific investigations propose that Orexin A may play a crucial role in the regulation of appetite and energy balance, making it a subject of considerable interest in the realm of obesity research. Research findings suggest that Orexin A, through its influence on hypothalamic circuits and neurotransmitter systems, has the potential to modulate feeding behavior and energy expenditure. The exploration of Orexin A’s involvement in appetite regulation may offer insights into the complexities of metabolic processes and pave the way for novel therapeutic approaches to address conditions related to disrupted energy homeostasis. [R]

Enhanced Cognitive Function

Orexin A has emerged as a potential player in the realm of cognitive function, with studies suggesting a link to improved cognitive processes such as attention, memory, and learning. Research has explored the expression of Orexin A receptors in key brain regions associated with cognitive tasks. The activation of these receptors may influence neurotransmitter release and synaptic plasticity, offering a potential avenue for enhancing cognitive abilities. While the exact mechanisms are still being elucidated, these findings underscore the potential role of Orexin A in cognitive enhancement, making it an intriguing subject for further investigation. [R]

Stress Response Modulation

Investigations propose that Orexin A may play a role in modulating response to stress, contributing to its broader impact on emotional and mental well-being. Studies have examined the interactions between Orexin A and the stress-responsive systems, including the hypothalamic-pituitary-adrenal (HPA) axis. Orexin A receptors are found in brain regions associated with stress regulation, and their activation may influence the release of stress hormones. The potential of Orexin A to modulate stress responses highlights its intricate involvement in neuroendocrine pathways, suggesting a potential link between Orexin A and stress resilience. [R]

Sleep Disorders Research

Ongoing research into Orexin A continues to yield valuable insights into the underlying mechanisms of sleep disorders, with potential implications for therapeutic interventions. Studies have explored the role of Orexin A in the regulation of sleep-wake cycles and its interaction with other neurotransmitter systems involved in sleep control. The discovery of Orexin A deficiency in conditions such as narcolepsy has sparked interest in developing targeted therapies that involve Orexin A modulation. While the therapeutic potential is recognized, it is important to acknowledge that the field is still evolving and that more research is needed to fully understand how Orexin A may be harnessed for the treatment of sleep disorders. [R] [R] [R]

How Does ‘Orexin A’ Work?

Orexin A exerts its effects through binding to specific receptors, known as OX1R and OX2R, which are predominantly distributed in the central nervous system. Upon binding, Orexin A has the potential to activate intracellular signaling pathways that influence neurotransmitter release and neuronal activity. The intricate interplay of Orexin A within neural circuits contributes to its role in promoting wakefulness and regulating various physiological functions. [R]

Frequently Asked Questions (FAQs)

Is ‘Orexin A’ a hormone?

No, Orexin A is not a hormone; it is a neuropeptide. Neuropeptides are tiny protein-like molecules that neurons utilize to communicate. Orexin A, also known as hypocretin-1, is a hormone that is generated particularly in the lateral hypothalamus of the brain and regulates alertness, arousal, and appetite.

Where is Orexin A produced?

Orexin A is primarily synthesized in the lateral hypothalamus of the brain.

Is Orexin A involved in sleep disorders?

Yes, Orexin A is associated with sleep disorders, and research into its mechanisms provides insights into conditions such as narcolepsy.

Summary

Orexin A is a neuropeptide originating from the lateral hypothalamus, recognized for its key role in regulating wakefulness, arousal, and appetite. Extensively studied, it has potential implications for cognitive function and stress response modulation. Despite its promising attributes, Orexin A is not recommended for human consumption, and its therapeutic applications are still being explored. BehemothLab Sells peptides only for research purposes. 

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Strength	5mg