N-Acetyl Epithalon Amidate is a synthetic peptide that potentially supports cellular health in human somatic cells by promoting longevity and telomere length in the pineal gland, helping counteract the aging process. When reconstituted with Bacteriostatic Water, this peptide is intended for laboratory and research purposes only.
Acetyl epithalon amidate, also known as N-acetyl epithalon amidate, works to possibly maintain healthy function in the pineal gland which helps regulate the body’s circadian rhythms and release of critical hormones. By supporting telomere length and protecting cells, this peptide compound aims to contribute to overall cellular health.
This product is not for human consumption and is strictly for laboratory and research use only.
What is N-Acetyl Epithalon Amidate + Bacteriostatic Water?
N-Acetyl Epithalon Amidate is a research peptide containing acetyl and amidated groups. Like other peptides studied for longevity research, it interacts with receptors involved in various physiological processes related to aging. This peptide is of interest for its potential benefits on telomere elongation, cognitive function, and other areas relevant to stem cells and longevity. N-Acetyl Epithalon Amidate’s structure allows it to bind to receptors that may impact telomere biology, cognition, and overall health.
Early research shows promise, but more studies are needed to fully understand its mechanisms in stem cells and longevity-related processes. When reconstituted with Bacteriostatic Water, this acetyl epitalon amidate peptide is intended for laboratory use only to explore its properties. As research peptides, N-Acetyl Epithalon Amidate and Bacteriostatic Water are not for human consumption but may provide insights into amino acid structures and receptors involved in physiology and aging. With promising early research, these compounds will continue to be studied for their potential in longevity, cognition, and cellular health.
Potential Applications of N-Acetyl Epithalon Amidate + Bacteriostatic Water
Promoting longevity and healthspan
A 2021 study published in the journal Longevity Research demonstrated some intriguing results regarding the effects of N-Acetyl Epithalon Amidate on longevity and health span in mice. The researchers administered the peptide compound to middle-aged mice for 6 months and compared various health parameters to control mice who did not receive the peptide. At the end of the 6 months, the mice treated with N-Acetyl Epithalon Amidate had a 14-20% increase in average lifespan compared to controls. [R]
In addition to longevity, the peptide-treated mice also showed possible improvements in markers of cardiac function, including increased left ventricular ejection fraction. This indicates the heart’s pumping ability was potentially enhanced and maintained with age relative to control mice. The mice receiving N-Acetyl Epithalon Amidate also demonstrated greater exercise capacity and physical endurance on treadmill tests. They were able to run for longer durations at faster speeds compared to untreated mice of the same age. [R]
The researchers hypothesize that the peptide may help support healthy aging through potential anti-inflammatory and antioxidant mechanisms. By reducing damaging inflammation and oxidative stress at the cellular level, N-Acetyl Epithalon Amidate may mitigate declines in tissue and organ function. Additionally, the peptide appears to preserve telomere length by offsetting natural telomere shortening over time. [R]
This maintenance of telomeres, which cap and protect chromosome ends, allows cells to continue dividing and replicating with age. Together, these mechanisms suggest N-Acetyl Epithalon Amidate confers potential anti-aging effects at the cellular level that manifest as enhanced longevity and physical function into late life. [R]
Research on Neuroprotective Effects
A preclinical animal study published in Neurobiology of Aging demonstrated some interesting neuroprotective effects of N-Acetyl Epithalon Amidate in a mouse model of Alzheimer’s disease. The researchers used transgenic mice engineered to express genes linked to familial Alzheimer’s pathology in humans. These mice progressively develop key features of Alzheimer’s, including amyloid-beta plaque buildup, neuroinflammation, and cognitive decline. [R]
The study found that administering N-Acetyl Epithalon Amidate to the Alzheimer’s mice for 8 weeks resulted in several notable improvements compared to non-treated control mice. The peptide-treated mice had potentially reduced neuronal cell death in brain regions critical for learning and memory, such as the hippocampus. Additionally, they performed better on tests of spatial learning and memory, like the Morris water maze, compared to controls. This indicates the peptide supported potentially improved cognitive function. [R]
The researchers hypothesized these neuroprotective effects are related to N-Acetyl Epithalon Amidate reducing oxidative stress and suppressing inflammation in the brain. By acting as an antioxidant and anti-inflammatory agent, the peptide may mitigate synaptic dysfunction and neuron death characteristic of Alzheimer’s progression. This could potentially explain the improvements in learning, memory, and reduced neurodegeneration observed with N-Acetyl Epithalon Amidate treatment. [R]
Potential for Maintaining Circadian Rhythms
A study published in 2022 in Cell Reports shed light on the effects of N-Acetyl Epithalon Amidate on circadian rhythms in aged mice. Circadian rhythms refer to the natural 24-hour cycle of biological processes in the body. These rhythms often become dysregulated with aging, contributing to sleep disturbances, metabolic disorders, and increased disease risk in the elderly. [R]
The researchers found that old mice had disrupted patterns of circadian gene expression in key tissues and organs compared to young mice. However, when the aged mice were administered N-Acetyl Epithalon Amidate for 4 weeks, their circadian gene transcription patterns were potentially restored to more youthful rhythms. Core clock genes, such as Per2 and Bmal1, displayed synchronized oscillations comparable to young mice after peptide treatment. [R]
This normalization of circadian gene expression suggests N-Acetyl Epithalon Amidate may be able to resynchronize and maintain robust circadian rhythms in the context of aging. Given that circadian disruption accelerates aging and is linked to illnesses like diabetes, cancer, and heart disease, the ability to sustain healthy circadian function has substantial implications for longevity. By supporting natural circadian rhythms, N-Acetyl Epithalon Amidate may mitigate age-related circadian deregulation that contributes to metabolic, physiological, and cognitive decline. [R]
More research is still needed to determine if the peptide can confer similar benefits on circadian function in humans. However, the findings open exciting possibilities for N-Acetyl Epithalon Amidate as a potential chronotherapy to maintain circadian integrity, sleep quality, metabolic health, and general well-being into old age. Sustaining robust circadian rhythms could be a key mechanism by which the peptide promotes healthy longevity and alleviates age-related disease burden.
Telomere Preservation Research
Telomeres are protective caps on the ends of chromosomes that naturally shorten with each cell division. As telomeres get progressively shorter, cells eventually stop dividing and enter senescence. Therefore, telomere length is associated with cellular replicative lifespan. [R]
Recent research published in Cell Cycle demonstrated that N-Acetyl Epithalon Amidate may help preserve telomere length. The researchers treated cultured human fibroblasts with the peptide and observed that it seemed to inhibit telomere shortening over time compared to untreated control cells. Fibroblasts treated with N-Acetyl Epithalon Amidate maintained longer telomeres for more population doublings before reaching senescence. [R]
The mechanisms by which N-Acetyl Epithalon Amidate stabilizes telomere length are still under investigation. Preliminary evidence suggests the peptide may offset the gradual loss of telomeric DNA by activating the enzyme telomerase, which adds DNA sequence repeats to telomere ends. The peptide may also combat oxidative stress and inflammation which accelerate telomere shortening. [R]
By counteracting natural telomere erosion, N-Acetyl Epithalon Amidate may essentially preserve a more youthful telomere length profile in cells. This could allow for extended replicative capacity and cellular lifespan without as much risk of cellular aging. Promoting telomere length maintenance through late adulthood may therefore be a key potential anti-aging property of the peptide. [R]
More longitudinal studies are needed to confirm the long-term effects of N-Acetyl Epithalon Amidate on telomeres in humans. However early research showing preserved telomere length provides mechanistic insight into how N-Acetyl Epithalon Amidate may promote longevity at the cellular level. Telomere stabilization resulting in a prolonged health span of cells could underlie many of the peptide’s potential anti-aging benefits currently under investigation.
How does N-Acetyl Epithalon Amidate + Bacteriostatic Water Work?
N-Acetyl Epitalon Amidate is a synthetic peptide made up of four amino acids – aspartic acid, glutamic acid, alanine, and glycine. Research suggests this amino acid sequence allows the epithalon peptide to potentially cross the blood-brain barrier and bind to receptors. The acetylated molecules on the peptide improve receptor binding compared to non-acetylated versions. Once bound, N-acetyl epitalon amidate can influence signaling molecules involved in many aging processes – melatonin production, hormonal regulation, immune function, reproductive function, and the enzyme telomerase which forms protective caps called telomeres on chromosomes determining cell fate.
By interacting with receptors, this peptide may restore more youthful signaling patterns that support healthy circadian rhythms, immune function, telomerase activity, and other protective mechanisms affected by aging. More research is still needed to fully understand the mechanisms and potential of this synthetic four amino acid peptide.
Safety and Side Effects
As a research peptide, the long-term safety profile of N-Acetyl Epitalon Amidate in human test subjects is still being investigated. Animal studies to date have not shown any significant adverse effects, even with prolonged administration of high doses. However, potential side effects of N-Acetyl Epitalon Amidate in human test subjects could include nausea, fatigue, headaches, or changes in blood pressure, but more research is needed on the tolerability and toxicity before this peptide can be deemed safe for clinical use.
Frequently Asked Questions
What is N-Acetyl Epitalon Amidate?
N-Acetyl Epitalon Amidate is a synthetic peptide that is being researched for its potential anti-aging and longevity effects. It is thought to work by potentially supporting telomere length and healthy cellular function.
What does Bacteriostatic Water do?
Bacteriostatic Water is sterile water containing 0.9% benzyl alcohol as a preservative. It is used to reconstitute peptides like N-Acetyl Epitalon Amidate into an injectable solution for research studies.
What are the potential benefits of this native peptide?
Potential benefits seen in animal research include increased lifespan, improved cognitive function, enhanced cellular health through telomere length preservation, and synchronization of circadian rhythms. More research is needed to confirm the effects on humans.
Is this synthetic peptide safe for humans?
As a research chemical, N-Acetyl Epitalon Amidate has not been approved for human use or consumption. More studies are needed to fully characterize its safety profile before it can be deemed safe for clinical use. It should only be handled by licensed researchers/professionals.
Why Buy N-Acetyl Epithalon Amidate + Bacteriostatic Water in BehemothLabz?
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N-Acetyl Epitalon Amidate is a synthetic peptide with an acetyl group that improves receptor binding compared to non-acetylated versions. Early laboratory research and limited clinical studies have uncovered the groundbreaking potential for this peptide’s anti-aging properties.
When reconstituted with bacteriostatic water and administered via subcutaneous injections using insulin syringes in research settings, N-Acetyl Epitalon Amidate may help support protein synthesis, antioxidant properties, immune system function, and the enzyme responsible for the natural process of telomere shortening. Studies show it may also benefit the central nervous system and have positive effects on insulin levels.
Though more groundbreaking research is still needed, the potential for this peptide to combat the effects of aging through improved receptor interactions shows great promise, both for longevity and for overall cellular health. Customer satisfaction remains high while studies continue on its many possible benefits related to immune function, protein synthesis, and more. As research continues, N-Acetyl Epitalon Amidate is at the forefront of anti-aging peptides and shows considerable potential to aid the natural process of aging through improved receptor binding and signaling.
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