Kisspeptin: Benefits, Side Effects, and Mechanism of Action

Kisspeptin is a synthetic neuropeptide used in reproductive health research. It has the potential to stimulate the patterns linked with sex hormones in preclinical models. Besides, it may also have some side effects if proper research guidelines are not followed. Let’s understand all this in detail here! 

What is Kisspeptin?

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Kisspeptin is a synthetic neuropeptide. It consists of a small chain of amino acid molecules, connected by peptide bonds. It is also called a gatekeeper to puberty, meaning that its absence may delay puberty. For this reason, researchers are investigating the compound in laboratory reproductive health studies. 

In early laboratory experiments, researchers found its potential to influence the pituitary gland and alter GnRH levels in preclinical models. Altering the GnRH levels may affect sexual hormonal levels, such as LH, FSH, and progesterone. All of these hormones are related to reproductive health in preclinical models. 

Mechanism of Action

After being administered to preclinical models during laboratory studies, kisspeptin tries to reach the pituitary gland. After reaching there, it may affect the pathways involved in the Gonadotropin-Releasing Hormone (GnRH) secretion. In return, the GnRH may move towards the anterior pituitary gland and stimulate the LH and FSH secretion in preclinical models. LH and FSH may affect gonadal patterns of sex hormone secretion in experimental models. 

Research Applications of Kisspeptin

The research applications observed in preclinical studies of kisspeptin are as follows: 

Influence Sex Hormone Secretion:

The first research application of kisspeptin is an influence on sex hormones in preclinical models. While investigating the compound, researchers observed that its effects on GnRH influence pathways related to LH and FSH in preclinical models. In return, the GnRH may impact the gonads and influence the patterns linked with sex hormones, testosterone, estrogen, and progesterone in preclinical models. 

Affects Reproductive Health: 

For reproductive health, sexual hormones are necessary in a balanced way. Excessive increases or decreases may affect the reproductive health of preclinical models. In this regard, researchers believe that kisspeptin influences the balance of sex hormones; therefore, it may also affect reproductive health in preclinical models. 

Affects Hypogonadism: 

Hypogonadism refers to low testosterone levels. To study it, researchers are using kisspeptin in laboratory experiments. In early studies, researchers found that kisspeptin’s effects on GnRH may affect testosterone levels in preclinical models. 

Role in Cancer Therapy: 

Some scientists also believe that kisspeptin may play a role in cancer therapy in laboratory studies. While investigating, scientists observed that kisspeptin has the potential to inhibit metastasis, the spread of cancer cells to other parts of the body. This potential role may limit the pathways involved in cancer cell growth in preclinical models during laboratory experiments. 

Associated Side Effects of Kisspeptin 

The associated side effects of kisspeptin are as follows: 

• Injection site reaction
• Fatigue
• Headaches
• Dizziness
• Flushing 
• Hormonal fluctuation 
• Nausea

Note: These side effects were observed during early laboratory studies on preclinical models. Therefore, they may vary from subject to subject. 

Legal Status

As for the legal status of kisspeptin, it is not allowed for human consumption as the FDA has not yet approved it. However, researchers can use it in laboratory experiments with preclinical models. 

Research Guidelines for Kisspeptin Experiment

To streamline your research and avoid the adverse effects of kisspeptin, researchers need to follow the recommended guidelines. Here are a few guidelines; let’s have a look at them.

• Always Start From a Low Dose: The first thing is to start from a low dose. A low dose allows preclinical models to adjust their internal systems to the dose. This also ensures better and optimal research results of the studies. 

• Be Hydrated Throughout the Experiment: It is also recommended to keep your research subjects hydrated throughout the experiment. This avoids the opposing sides of the compound. 

• Sleep Well during Research Experiment: Avoid sleep deprivation of the preclinical models during laboratory experiments; otherwise, it would cause behavioural and endocrine changes. These changes may impact the final results of your research studies. 

• Adhere to the Guidelines: Following the recommended guidelines is another way to streamline your research experiment. Always stick to the guidelines; follow whatever the research requirements are. 

• Use Non-Human Research Subjects: As kisspeptin is not approved for human consumption, researchers are advised to use non-human research subjects in laboratory studies. 

Final Thought 

Kisspeptin is a synthetic neuropeptide. It has been studied in experiments related to sexual hormonal dysfunctions. Early studies have shown that it influences LH and FSH parameters in preclinical models. This influence may affect the reproductive health of preclinical models during laboratory studies. Besides its potential impact, it may also cause some side effects, including headache, fatigue, dizziness, and hormonal fluctuation in preclinical models. 

Frequently Asked Questions (FAQs)

What is the best place for buying kisspeptin online? 

The best place to purchase kisspeptin online is BehemothLabz. 

Where can I buy kisspeptin online for my laboratory studies? 

You can buy kisspeptin online from BehemothLabz for your laboratory studies. 

What is kisspeptin used for in laboratory studies? 

Kisspeptin is used to study its effects on reproductive health and assess its influence on sexual hormone levels in preclinical models. 

What is the role of kisspeptin in reproduction? 

The potential role of kisspeptin in reproduction is to influence the pathways associated with sex hormones, testosterone, progesterone, and estrone, in preclinical models. 

Can kisspeptin be taken with HCG during laboratory studies? 

Yes, HCG may be taken with kisspeptin during laboratory studies. This combination of these compounds may expedite their impacts on reproductive health in preclinical models. 

References: 

1. Oakley, Amy E., Donald K. Clifton, and Robert A. Steiner. “Kisspeptin signaling in the brain.” Endocrine reviews 30.6 (2009): 713-743.
2. Roseweir, A. K., and R. P. Millar. “The role of kisspeptin in the control of gonadotrophin secretion.” Human reproduction update 15.2 (2009): 203-212.
3. Hussain, Mehboob A., Woo-Jin Song, and Andrew Wolfe. “There is kisspeptin–and then there is kisspeptin.” Trends in Endocrinology & Metabolism 26.10 (2015): 564-572.
4. De Bond, Julie-Ann P., and Jeremy T. Smith. “Kisspeptin and energy balance in reproduction.” Reproduction 147.3 (2014): R53-R63.
5. Hu, Kai-Lun, et al. “Kisspeptin/kisspeptin receptor system in the ovary.” Frontiers in endocrinology 8 (2018): 365.
6. d’Anglemont de Tassigny, Xavier, and William Henry Colledge. “The role of kisspeptin signaling in reproduction.” Physiology 25.4 (2010): 207-217.