PNC-27

PNC-27 is a synthetic peptide widely studied for its potential anti-cancer properties. It comprises a segment of the p53 tumor suppressor protein fused to a cell-penetrating peptide sequence. The peptide has the potential to target and kill cancer cells by binding to the HDM-2 protein, which is often overexpressed in cancer cells. Some preclinical studies on test subjects and anecdotes suggest its potential benefits, including selective cancer cell targeting, inducing necrosis of cancer cells, non-toxicity for healthy cells, and working against different types of cancer. Based on these potential roles, PNC-27 may be used to treat cancer issues in research subjects. 

How does PNC-27 Work?

According to preclinical studies, PNC-27’s mechanism of action involves targeting HDM-2. By binding to the HDM-2, it may induce the formation of transmembrane pores, ultimately leading to the necrosis of the cancer cells and sparing the normal cells in subjects. 

Research shows that PNC-27 contains a p53-binding domain that allows it to attach to the HDM-2. This binding may specifically occur on the cell membrane of the cancer cells while sparing normal cells. After successful binding, PNC-27 may integrate into the cancer cell membrane which leads to the formation of pores. This leads to the disruption of the cell’s structural integrity, causing necrosis, i.e., uncontrolled cell death which is different from traditional chemotherapy. 

Properties of PNC-27 Peptide 

• CAS Number: 129954-34-3

• Molar Mass: 4031.7 g/mol

• Chemical Formula: C188H293N53O44S

• IUPAC Name: Pro-Pro-Leu-Ser-Gln-Glu-Thr-Phe-Ser-Asp-Leu-Trp-Lys-Leu-Leu-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly-OH

• Shelf life: 12 months

Potential Benefits of PNC-27

Preclinical studies have suggested some potential benefits of PNC-27. These include: 

• Selective Cancer Cell Targeting:

Research studies have shown in research subjects that PNC-27 binds to the HDM-2 protein, which is overexpressed on the cell membranes of the cancer cells. This selective binding may lead to the formation of pores in the cancer cell membrane leading to the death of abnormal cells. This process may not cause any harm to the healthy cells in subjects. Moreover, this selective targeting of PNC-27 is unlike the traditional chemotherapy sessions which may affect both the cancerous and normal tissues of test subjects. [1]

• Induces Cancer Cell Necrosis:

Unlike traditional cancer treatments that cause apoptosis, i.e., programmed cell death, PNC-27 has been shown to form pores in the cancer cell membranes. The pores cause necrosis, i.e., uncontrolled cell death. For instance, studies have shown that PNC-27 has effectively induced necrosis in K562 leukemia cells, which have expressed HDM-2 on their membrane, without affecting healthy lymphocytes. [2]

• Works Across Different Cancer Types:

With potential efficacy across various cancer types, PNC-27 peptide has been investigated as effective for pancreatic, breast, leukemia, and ovarian cancers. Research indicates that PNC-27 may inhibit growth and induce cytotoxicity in primary epithelial ovarian cancer cells taken from test subjects.  Moreover, studies have also revealed that PNC-27 binds to HDM-2 through the p53-binding domain in MIA-PaCa-2 pancreatic cancer cells. This may lead to transmembrane pore formation and subsequent cell necrosis. [3] 

• Non-Toxic to Healthy Cells:  

Preclinical studies suggest that PNC-27 inflicts damage and death to cancer cells and spares the normal cells. For instance, a study demonstrates that it effectively induced the death of K562 leukemia cells expressing HDM-2 on their membrane. Further studies have shown that it can enter the cancer cells and bind to the mitochondrial membrane leading to mitochondrial disruption and cell death. In the study, this effect was observed in cancer cells but not in normal cells. [3]

Why Choose BehemothLabz to buy PNC-27 Online?

BehemothLabz provides top-quality PNC-27 peptides for sale!

Are you interested in studying PNC-27? When purchasing it online, it is essential to check the credibility and authenticity of the supplier. Choosing BehemothLabz for buying PNC-27 online is the best choice as we present several attributes that may appeal to the researchers. 

In addition to quality assurance, we emphasize rigorous quality control and testing procedures. BehemothLabz offers pure PNC-27 at an affordable price with reliable and trusted customer services.  Place your order now with BehemothLabz and inspire your research journey! 

Frequently Asked Questions

What is the best place to buy PNC-27 online?

The best place to buy PNC-27 online is BehemothLabz. It ensures high-quality research products that provide optimal and effective research results. 

What is the difference between PNC-27 and PNC-28?

Both PNC-27 and PNC-28 are peptides, which contain the same sequence of amino acids but the PNC-28 lacks the first six amino acid residues of PNC-27. 

Are there any known side effects of PNC-27?

Since it has not undergone human clinical trials, PNC-27’s potential side effects are not well-documented. However, possible concerns may include immune reactions or unintended toxicity. 

What type of cancers has PNC-27 been studied for?

Preclinical studies have shown its effects on various types of cancer like pancreatic cancer, ovarian cancer, breast cancer, lung cancer, and leukemia. However, No completed human trial confirms its effectiveness.

References 

1. Sookraj, Kelley A., et al. “The anti-cancer peptide, PNC-27, induces tumor cell lysis as the intact peptide.” Cancer chemotherapy and pharmacology 66 (2010): 325-331.
2. Sarafraz-Yazdi, Ehsan, et al. “Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes.” Proceedings of the National Academy of Sciences 107.5 (2010): 1918-1923.
3. Davitt, Katlin, et al. “The anti-cancer peptide, PNC-27, induces tumor cell necrosis of a poorly differentiated non-solid tissue human leukemia cell line that depends on expression of HDM-2 in the plasma membrane of these cells.” Annals of Clinical & Laboratory Science 44.3 (2014): 241-248.

Strength	5mg

1st Party COA