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Yohimbine is an alkaloid found naturally in the Pausinystalia yohimbine bark extract and the Rauwolfia serpentina plant. Yohimbine is a stimulant that primarily acts on the body’s alpha-2-adrenergic receptors. It is best known for its alleged ability to improve male sexual dysfunction and increase fat burning (lipolysis).
A yohimbe supplement is being studied for its effect on weight loss, body composition, phobia treatment, and orthostatic hypotension, though evidence for many of these conditions is lacking.
Yohimbe supplements (also yohimbine supplements) are understood as research chemicals meaning they are not recommended for human consumption. Behemoth Labz sells its best yohimbe supplements for the purpose of research only.
Yohimbine is found naturally occurring as an alkaloid in the Pausinystalia yohimbe tree (also known as Corynanthe yohimbe) and in the plant Rauwolfia Serpentina, as well as the Rauwolfia family of plants in general.
Yohimbine is a molecule known as aphordine, corynine, hydroaergotocin, and quebrachine.
Yohimbine chloride (yohimbine HCL), a standardized form of yohimbine, is believed to address erectile dysfunction. Controlled studies suggest that it is not always an effective treatment for impotence, and evidence of increased libido is only anecdotal.
Yohimbine hydrochloride has also been used to treat sexual side effects caused by some antidepressants (SSRIs), female hyposexual disorder, autonomic failure, xerostomia, and as a probe for noradrenergic activity.
Yohimbine has the potential to treat post-traumatic stress disorder (PTSD) to aid in the recall of traumatic memories. Yohimbine’s use outside of therapeutic settings may not be appropriate for people with PTSD.
Today yohimbine comes in the form of capsules or powdered formula. Other supplements are gluten-free. The best yohimbine supplement, such as sold by Behemoth Labz and Raesun botanics yohimbine HCL, is the product of good manufacturing practices.
Increased firing of neurons in the medial prefrontal cortex is linked to the mechanism of action of many ADHD drugs, including methylphenidate (Ritalin) and noradrenaline-based drugs like desipramine or atomoxetine, where signaling via D1 receptors and involvement of A2A receptors appears to be critical. [R] [R]
Yohimbine can synergistically enhance Methylphenidate signaling, with 1mg/kg doubling the firing rate in rats in PCNs. Although neither 1-adrenergic nor A1A antagonists were effective, yohimbine in isolation does not alter signaling in these neurons; blocking D1 receptors also eliminates the augmentation. [R]
Yohimbine has shown the ability to reverse the anti-aphrodisiac effects of alpha-2-adrenergic agonists in rats (such as clonidine) or to negate some chemicals that antagonize sexuality (such as Naloxone) while increasing sexual motivation in otherwise healthy rats.
This effect is independent of the state of the genitalia (working in genital anesthetization models), the state of exhaustion, and the hormone [testosterone] (still effective despite castration), testosterone of which is known to be associated with increased libido in men and women. [R]
Because of its dependability, yohimbine is being investigated to increase noradrenaline in a study that aimed to assess the effects of adrenergic stimulation on cerebral blood flow.
Yohimbine was found to reduce cerebral blood flow in most subjects (in a range of 4-29%, with a mean decrease of 14.5%). Still, one subject with a minor panic attack experienced an increase in blood flow (+23%), and neither group changed in blood flow selective for one brain region over another. [R]
Prior to the introduction of PDE5 inhibitors, yohimbine was commonly used as a first-line treatment for erectile dysfunction due to its alpha-2-adrenergic inhibitory potential.
According to a review that cited the following trials, the efficacy range is 34-73%, which could be attributed to potency in people with psychogenic erectile dysfunction. [R] [R] [R]
Yohimbine and L-Arginine combination therapy has shown preliminary benefits, with greater efficacy in mild to moderate (rather than severe) erectile dysfunction. [R] [R]
Yohimbine has the potential to cause fat loss vicariously through the release of adrenaline; adrenaline is a beta-adrenergic receptor activator. However, this adrenaline increase may fade over time, reaching statistical insignificance two weeks after daily ingestion. [R]
Increases in plasma-free fatty acids and alpha2-adrenergic receptor density are similar at both time points, implying that yohimbine selectively loses the adrenaline spike but not the direct receptor fat-burning effects. [R]
Yohimbine is a selective alpha-2-adrenergic antagonist. In other words, it targets and inhibits a class of receptors in the nervous system that respond to the neurotransmitter norepinephrine. (noradrenaline).
Yohimbine’s stimulatory and “hyperadrenergic” effects are caused by alpha-2 receptor antagonism, which increases the sympathetic nervous system’s release of norepinephrine.
Antagonism of alpha-2 receptors also inhibits penile smooth muscle contraction and may improve nitric oxide-mediated smooth muscle relaxation, all of which promote erection and explain the improvement in ED symptoms after yohimbine supplementation.
Yohimbine also inhibits the activity of alpha-2 receptors on fat cells, which are normally activated by norepinephrine to suppress fat release. The inhibition of norepinephrine’s antilipolytic effect allows for more lipolysis (fat burning).
The main issues with Yohimbe as a dietary supplement are incorrect labeling and potentially serious side effects. This chemical compound could also affect cardiovascular health.
Yohimbine commonly causes the following side effects:
Yohimbine is the primary alkaloid found in the bark of the Western Africa evergreen Pausinystalia yohimbe Pierre (formerly Corynanthe yohimbe), which belongs to the Rubiaceae family. (Madder family). Yohimbe contains 31 other yohimbine alkaloids.
Yohimbine has been used as an aphrodisiac in Africa for years. Now the terms yohimbine, yohimbine hydrochloride, and yohimbe bark extract are all related, yet these are distinct from each other.
Yohimbine HCl (yohimbe HCL) is the active ingredient found in the bark of the Pausinystalia yohimbe tree.
However, the levels of yohimbine in yohimbe extract vary and are frequently very low. As a result, while yohimbe bark has traditionally been used to treat male erectile dysfunction, insufficient scientific evidence exists to form a firm conclusion in this area.
Yohimbe could refer to the common English name of the tree species P. johimbe (also known as Corynanthe johimbe) and, by extension, the name of an aphrodisiac made from the bark of that tree. Yohimbine, on the other hand, is a pure alkaloid that can be isolated from yohimbe bark.
Yohimbine caused a significant decrease in whole-brain absolute CBF, with regional decreases being most significant in cortical areas. After normalization to the whole brain, the medial frontal cortex, thalamus, insular cortex, and cerebellum showed significant increases.
Yohimbine therapy has not been linked to serum enzyme elevations or clinical liver disease in small clinical trials or case series. Although yohimbine is commonly found in herbal weight loss and muscle-building combinations, it has not been linked to cases of clinically obvious acute liver injury. [R]
Yohimbine is a 2-adrenoceptor antagonist that is used to treat erectile dysfunction. Its most common side effects at high doses are increased blood pressure and mild anxiety.
Behemoth Labz is the best place to buy Yohimbine HCl online in the market today. We sell our best yohimbe supplement with guaranteed quality to satisfy our clients who are researching about its potential applications. Our product is often listed among the five best yohimbe supplements.
We have been around since 2014, supplying the highest-quality research compounds money can buy. All of our products come with a 100% satisfaction guarantee, free and fast shipping, and a money-back guarantee on Yohimbine HCl.
Yohimbine is a prototypical 2-receptor antagonist that has long been used as a possible treatment for erectile dysfunction. However, the precise mechanism of yohimbine action remains unknown.
Interestingly, DPQ and quantitative drug-likeness estimates show that yohimbine compounds meet fundamental drug-like criteria.
Yohimbine’s 2-adrenergic receptor inhibitory activity is beneficial in various disease conditions, including erectile dysfunction, myocardial dysfunction, inflammatory disorders, and cancer.
However, few studies, albeit at higher doses, reported toxicological concerns following yohimbine treatment for erectile dysfunction.
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Caleb Meyer –
Amazing quality yohimbine! Results coming in quick.
Frank T –
Darren Digman –
Very reliable products. I have been on Behemoth Labs for months and was not disappointed once.
This definitely amps you up.
Howard W R –
Increase in vitality. Totally hooked.
James Warner –
What I like about you guys is that you offer excellent customer service and sell a variety of good research chemicals.
It helped me cut the last 8lbs of extra weight that was sticking to me.
E W Upton –
Deontae Hackett –
Happy with the product I received. Well packed.
James R –
Energy and Stamina formula. No side effects!
A Moen –
Khalil Maggio –
I’ve lost a good amount of weight since I started using this.
John Collins –
Gets the job done and has a noticeable increase in energy and stamina.
Patrick Foster –
This stuff is so good, well it’s made by Behemoth Labs, so what else did you expect.
I have been losing a bit of weight but what I am most impressed by is how this has helped me in the gym, my overall performance has increased greatly.
Feeling healthier with lower blood pressure and weight loss.
The product was excellent and packed great. Results of the research were consistent with expectations. Highly recommended!
Peter W –
If anyone need a little help to lose weight and you do a little workout, trust me you will with this brand of Yohimbine.
I’ve been using this Yohimbine now for about two weeks plus, and I do seem to have additional energy when I work out. Recovery time seems to have lessened as well.
R Goldner –
I use Yohimbine Capsules for support to my immune system and it works good.
Edgar A –
Great weight loss, I will be buying more of this very soon.