SS-31 Peptide: Scientific Overview, Benefits, Side Effects, and Mechanism

New compounds are emerging with each passing day due to the ongoing laboratory research. Among such emerging compounds, the SS-31 peptide is on the list. It is a synthetic peptide consisting of four amino acids. It has shown greater potential in influencing various pathways in experimental models during laboratory research.

Let’s explore what these pathways are and how the SS-31 peptide influences them. Read this blog to get to know the nature of the S-31 peptide!

What is SS-31 Peptide?

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SS-31 is a synthetic tetrapeptide composed of D-Arg-2′6′-dimethylTyr-Lys-Phe-NH2 (D-arginine, 2′,6′-dimethyltyrosine, lysine, and phenylalanine).. It is also known as MTP-131, elamipretide, and Bendavia.

It has shown a greater potential to impact specific patterns linked with mitochondrial integrity during laboratory trials on non-human experimental models. While influencing the biomarkers of mitochondria, it may affect mitochondrial protection, oxidative stress, and patterns of neuroprotection in research models during clinical trials.

How Does the SS-31 Peptide Work?

During in vitro trials in a controlled laboratory environment, the SS-31 peptide was observed to protect mitochondrial activities. Cardiolipin, a phospholipid molecule inside the cell, maintains mitochondrial integrity. It may not work correctly when it gets damaged or ages. This can also lead to a harmful substance, Reactive Oxygen Species (ROS), in research models during laboratory trials. The SS-31 peptide may protect the cardiolipin and affect bioenergetic patterns linked with ATP production in experimental models.

Research further explored that it may lead to a potential increase in ATP output, reduced biomarkers associated with senescence, and diminished oxidative imbalance in experimental models in laboratory investigations.

Potential Benefits of SS-31 Peptide in Research Investigations

The potential benefits of the SS-31 peptide in experimental models during preclinical trials are as follows:

Potential Effect On Mitochondrial Stability

In preclinical trials on laboratory experimental models, the SS-31 peptide affected the biomarkers linked with mitochondrial stability. Laboratory research further explored that such stability occurred by affecting cardiolipin patterns. Influencing cardiolipin has reduced indicators associated with oxidative stress and protected mitochondrial properties effectively in experimental settings. [1]

Potential To Exhibit Neuroprotective Properties

In phase II preclinical research on animal models, the SS-31 peptide has also impacted neural activities. Such an impact on neural pathways may occur by influencing the patterns associated with cardiolipin, a phospholipid molecule. The cardiolipin molecules may keep nerve cells healthy and alive, as observed in animal model studies in the laboratory.

Additionally, it may also modulate biomarkers associated with oxidative stress. In return, this may influence neuroprotective pathways in experimental models in clinical settings. [2]

Modulating Aging-related Cellular Pathways

Some preclinical studies on animal models also suggest that the SS-31 peptide may modulate aging-related cellular pathways. Studies have shown that it may influence the indicators linked with aging in experimental models. Such influence may also impact the cellular processes, which modulate aging-related pathways in animal models during laboratory trials. [3]

Associated Side Effects of SS-31 Peptide in Laboratory Research

Although the SS-31 peptide has shown potential benefits in experimental models in research trials, it may also cause some mild side effects. These mild side effects were observed during initial in vitro research trials and were effectively tackled through following the research protocols. The list of these side effects is as follows:

• Headache
• Fatigue
• Injection site reaction
• Dizziness
• Vomiting

Note: These side effects may vary from subject to subject and are dependent on various factors. These factors may include research settings, laboratory environment, and the physical status of experimental models.

Is SS-31 Peptide Legal?

SS-31 peptide is only legal for laboratory research. Researchers can only use it to explore its nature in laboratory trials on experimental models. Its human consumption is strictly prohibited, as the FDA and WADA have not yet approved it.

Is SS-31 Peptide Safe to Use in Research?

Yes, the SS-31 peptide is safe for laboratory experiments on research models. In previous laboratory trials, no serious repercussions were observed except for a few mild side effects, as mentioned above. Therefore, clinical scientists or researchers may use it by following the recommended guidelines and proper research protocols.

Conclusion

SS-31 peptide is laboratory-synthesized and consists of four amino acids. It has shown potential in modulating the pathways linked with mitochondrial activities in research models. This modulation may support mitochondrial stability, exhibit neuroprotective properties, and influence cellular changes commonly observed during aging in experimental models. Apart from the SS-31 peptide benefits, it may also cause minor side effects; however, these side effects may easily be managed through research protocols in experimental models.

Disclaimer: Human consumption of SS-31 peptide is illegal, as the FDA and WADA have not approved it. Thus, its human consumption may lead to legal proceedings. Moreover, terms like research subjects, experimental models, and research models refer to non-human research subjects used in laboratory research.

Frequently Asked Questions (FAQs)

What is the best place to buy the SS-31 peptide online?

The best place to buy the SS-31 peptide online is BehemothLabz. It is the only place that sells the SS-31 peptide for pure research purposes. Our products are specially designed to address and fulfill the needs, research goals, and requirements. Moreover, with a secure payment method, our prices are reasonable and within your buying range.

What is the use of the SS-31 peptide in laboratory research?

Laboratory research on experimental models studies its influence on the pathways linked with mitochondrial integrity. The research further seeks its impact on the oxidative stress patterns in research models in clinical investigations.

What are the benefits of the Elamipretide peptide in research models during trials?

The benefits of the Elamipretide peptide may include mitochondrial protection, neuroprotection, and the ability to influence cardiovascular patterns in experimental models in laboratory trials.

What are the disadvantages of peptides in research subjects in clinical trials?

The SS-31 peptide has demonstrated no severe disadvantages in non-human research subjects. However, it may still cause mild to moderate effects, such as fatigue, dizziness, and vomiting, in research subjects during clinical investigations.

References:

1. Hou, Yanjuan, et al. “Mitochondria-targeted peptide SS-31 attenuates renal injury via an antioxidant effect in diabetic nephropathy.” American Journal of Physiology-Renal Physiology 310.6 (2016): F547-F559.
2. Zhu, Yuexin, et al. “SS‐31, a mitochondria‐targeting peptide, ameliorates kidney disease.” Oxidative Medicine and Cellular Longevity 2022.1 (2022): 1295509.
3. Sweetwyne, Mariya T., et al. “The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age.” Kidney International 91.5 (2017): 1126-1145.
4. Thomas, Dolca A., et al. “Mitochondrial targeting with antioxidant peptide SS-31 prevents mitochondrial depolarization, reduces islet cell apoptosis, increases islet cell yield, and improves posttransplantation function.” Journal of the American Society of Nephrology 18.1 (2007): 213-222.