Tesamorelin vs Ipamorelin: A Comprehensive Overview

Are you curious about Tesamorelin vs Ipamorelin? These peptides are often compared and contrasted due to their potential benefits in the research field. 

Although both peptides have shown an increase in endogenous growth hormone (GH), Ipamorelin is more effective for muscle growth, whereas Tesamorelin is superior for fat loss. To understand the differences in more detail, read on to learn everything you need to know about Tesamorelin and Ipamorelin. 

What is Tesamorelin?

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Tesamorelin is a synthetic peptide and growth hormone-releasing hormone (GHRH) analog. Canadian technology company Teratechnogies created it in the 1990s. As a growth hormone stimulator, it has shown the potential to reduce excess visceral adipose tissue (VAT) in HIV-positive subjects with lipodystrophy. In research participants, Tesamorelin may improve body composition and has been shown to reduce visceral fat. However, its effects on insulin sensitivity are still being investigated. 

What is Ipamorelin? 

Like Tesamorelin, it is a synthetic peptide. However, Ipamorelin is a selective ghrelin mimetic that stimulates the release of GH by binding to ghrelin receptors (GHS-R1a) in the pituitary and hypothalamus of subjects. With a five amino acid chain, Ipamorelin is much simpler than Tesamorelin. Research studies have shown its potential benefits, including fat loss, muscle growth, and anti-aging effects. 

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Tesamorelin vs Ipamorelin: Side-by-Side Comparison  

Although both peptides have been shown to boost the growth hormone, they are still different in their mechanism of action, benefits, and side effects observed in test participants. Below is a comprehensive comparison between Ipamorelin and Tesamorelin. 

1. Mechanism of Action 

Due to different receptor interactions, Tesamorelin and Ipamorelin have distinct mechanisms of action. On the one hand, Tesamorelin binds to the GHRH receptor in the anterior pituitary to trigger the natural GH-releasing pathways. This may lead to a gradual increase similar to the body’s natural pattern in the GH levels. 

Conversely, Ipamorelin mimics ghrelin and binds to the growth hormone secretagogue receptor (GHS-R1a). This triggers a pulsatile GH release without affecting cortisol or prolactin levels. Research studies have shown that it also suppresses somatostatin, a hormone that inhibits the production of GH. This action may enhance the body’s natural ability to release growth hormones. 

2. Benefits 

With growth hormone-releasing capabilities, Ipamorelin and Tesamorelin have shown several but distant benefits in research investigations. Researchers conducted a thorough research on mice and rats and have found the following benefits: [1]

• Muscle mass: Muscle mass is the foremost benefit shown in rats and mice. Ipamorelin has demonstrated the potential to increase the level of growth hormones in test subjects. Such growth hormones, in return, may accelerate muscle growth, leading to increased lean muscle mass in subjects. [1]
• Fat loss: Another potential benefit is fat loss in research subjects. As mentioned above, Ipamorelin potentially increases the growth hormones in test subjects. In the presence of growth hormones, the rate of metabolism and lipolysis may also be enhanced. The enhanced rate of metabolism and lipolysis may gradually lead to fat loss in the subject. [2]. 
• Improved energy: As mentioned earlier, the Ipamorelin peptide may enhance the metabolic rate of research subjects. An increased metabolic rate may utilize more fats and thus provide more energy to subjects for various functions. [3]
• Sleep pattern: Studies have also observed that the Ipamorelin peptide may impact the sleep patterns of test subjects. It has the potential to enhance stage 4 and REM, which in return leads to better sleep patterns in subjects. [3]

In contrast, Tesamorelin has shown the following benefits in research investigations. 

• Visceral fat loss: As a potent peptide for weight loss, Tesamorelin may trigger the metabolic response to help lose test subjects’ abdominal or visceral fat. For example, clinical studies have shown that it may significantly reduce VAT in HIV-infected subjects with abdominal fat accumulation. [1]
• Muscle mass: Tesamorelin has also demonstrated increased muscle mass but at a slower rate than Ipamorelin. This role may be performed by helping the muscle fiber of research subjects to enhance lean muscle mass. [2]
• Stamina: With increasing muscle mass, Teramorelin peptide may also improve the stamina of research subjects. Myofibrillar hypertrophy by Tesamorelin is directly linked with improved stamina and strength. [2]
• Lipid profile: In addition to enhanced muscle mass, Tesamorelin may also improve the lipid profile of the research participants. It has shown a decrease in triglyceride levels and the cholesterol-to-high-density lipoprotein ratio. [3]

3. Results 

Research studies have shown that Ipamorelin increases growth hormone levels more than Tesamorelin.  It may increase GH levels by 3 to 13-fold above baseline levels in research subjects.  Similarly, Ipamorelin has also been more effective for muscle mass. Conversely, Tesamorelin is generally considered more effective for fat loss. A research study indicates that it may help reduce adiposity by about 20% in a year and decrease triglyceride levels by approximately 25% over 26 weeks. However, the results may differ depending on dosage, frequency, and the subject’s health condition. 

4. Side Effects 

While both peptides have shown several benefits, they may also be associated with some side effects, but distant ones. In research subjects, Tesamorelin may cause injection site reactions, muscle aches, swelling, and increased blood sugar levels. Ipamorelin, on the other hand, may be associated with headache, nausea, fatigue, and injection site reactions. However, side effects may differ depending on dosage and usage length. 

Which Peptide is Better?

The best choice between these two peptides depends on research goals and objectives. If the research aims to study fat loss, the preferred option is Tesamorelin between these two peptides. However, Ipamorelin has shown more effective results for muscle growth in research investigations. This means that it can be a good option for studying muscle growth. 

Necessary Precautions to be Considered 

Considering some essential precautions is vital to get safe and effective results in research studies. These include:

• Medical healthcare consultation: While studying Tesamorelin and Ipamorelin, always consult medical professionals to ensure safety. 
• Monitoring the progress:  Always monitor the health progress of the subject when studying these two peptides. 
• Storage: Always store these peptides in the refrigerator to maintain their stability and effectiveness.

Conclusion

While comparing Tesamorelin and Ipamorelin has gained significant attention in the research circle, they have shown several benefits, including fat loss and increased muscle mass in test participants. As stimulators of growth hormones, both may induce various therapeutic effects in research settings. However, they are distant in terms of their mechanism of action, benefits, and side effects.

Frequently Asked Questions

Can Tesamorelin and Ipamorelin be administered together?

Yes, Tesamorelin and Ipamorelin can be combined to improve results such as fat loss and muscle growth in research subjects. 

Which peptide can increase the insulin-like growth factor-1 (IGF-1)?

Both Tesamorelin and Ipamorelin may increase the insulin-like growth factor-1 (IGF-1) by stimulating growth hormones that, in turn, act on the liver and other cells to release IGF-1. 

Where to buy Tesamorelin and Ipamorelin online?

Are you interested in studying Tesamorelin and Ipamorelin? Consider buying them online from BehemothLabz. It ensures high-quality research peptides at affordable prices. Besides quality, its products also provide optimal and effective results in research investigations.

Which peptide is legal and safe?

Generally, Tesamorelin and Ipamorelin are considered safe and legal for research studies. Tesamorelin is FDA-approved for reducing visceral fat in HIV-infected subjects. However, these are not approved for human consumption. 

References 

1. Grunfeld, Carl, Argyris Dritselis, and Peter Kirkpatrick. “Tesamorelin.” Nature Reviews Drug Discovery 10.2 (2011): 95-97.
2. Stanley, Takara L., et al.. “Effects of tesamorelin on non-alcoholic fatty liver disease in HIV: a randomized, double-blind, multicentre trial.” The Lancet HIV 6.12 (2019): e821- e830.
3. Raun, Kirsten, et al. “Ipamorelin, the first selective growth hormone secretagogue.” European journal of endocrinology 139.5 (1998): 552-561.