Follistatin 315 vs Follistatin 344

Follistatin 315 and 344 are the isoforms of the naturally occurring follistatin peptide. They share similarities but differ in structure, mechanism, and half-lives. So, what are isoforms? What similarities do follistatin 315 and 344 share, and how do they differ from each other?

Here is a detailed guide explaining the term isoform and the key differences and similarities between follistatin 315 and 344. Read this blog to find answers to all your questions related to follistatin 315 and 344.

What is Follistatin Peptide?

Follistatin is a naturally occurring peptide. It has also been developed in the laboratory and is available for various investigations/research. Research studies have found it to be very promising in affecting these pathways, including myostatin inhibition and activin proteins, which are members of the TGF-beta family.

Similarly, the studies further demonstrated that it also affects the patterns linked with Akt in laboratory investigations of research subjects. Such influence of various pathways may modulate cellular growth, improve skeletal integrity, and muscle hypertrophy in subjects.

Isoforms of Follistatin:

Isoforms are the different versions of the same protein. They originate from a similar gene but differ in structure and mechanism. In the case of follistatin peptide, there are two prominent isoforms: follistatin 315 and follistatin 344. Here, both are thoroughly explained.

What is Follistatin 315?

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It is one of the prominent isoforms of the follistatin peptide. Because it consists of 315 amino acid molecules, it is known as follistatin 315. Research studies suggest that it is found in the extracellular fluid of experimental models.

In vitro research has explored the potential of follistatin 315 to bind to and inhibit specific proteins. These proteins are myostatin and activin, both members of the TGF-1 family. Such influence may impact the pathways associated with skeletal integrity and muscle hypertrophy in research subjects participating in laboratory trials.

What is Follistatin 344?

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Follistatin 344 is another prominent isoform of the follistatin peptide. It consists of 344 amino acid molecules, hence it is known as follistatin-344. It is used for localized actions in laboratory research on experimental models. Unlike follistatin 315, it does not enter the extracellular fluid in experimental models.

Laboratory research shows that it may influence the pathways linked with myostatin inhibition and activin proteins in research subjects. Such influence may impact the indicators associated with muscle hypertrophy, reproductive physiology, and skeletal integrity in laboratory models during clinical trials.

Key Differences between Follistatin 315 and 344

They are the isoforms of follistatin peptide. Here are the key differences between follistatin 315 and 344:

Features	Follistatin 315	Follistatin 344
Amino Acid Length	It contains 315 amino acid molecules.	It contains 344 amino acid molecules.
Structure	It lacks an addition of 29 amino acid molecules.	It has an addition of 29 amino acid molecules at the C-terminal end.
Distribution in Research Subjects	It circulates through the extracellular fluid in experimental models and influences pathways.	It is mainly used for localized action in research subjects during clinical trials.
Half-Life	It has a longer half-life in extracellular fluid.	It has a shorter half-life.
Research Focus	It has a main research focus to explore its influence on the patterns linked with muscle hypertrophy and skeletal integrity.	The primary research focus is to explore its influence on the indicators associated with reproductive physiology and muscle hypertrophy.
Solubility	It is less soluble in water or extracellular fluid.	It travels more easily in extracellular fluid or water.

Key Similarities between Follistatin 315 and 344

Here are a few similarities between follistatin 315 and 344:

• They Both Belong to the Same Protein Family: They belong to the same protein family. Their parent compound is follistatin peptide, and they are isoforms of it.

• Myostatin Inhibition: They act on the myostatin protein, inhibiting its mechanism in experimental models and during clinical trials. Inhibition of myostatin protein may influence the pathways of research subjects related to muscle hypertrophy.

• Both are non-steroidal, which means they don’t carry the risks associated with steroids.

• Similar Influence on Muscle Hypertrophy: They have a similar influence on the patterns associated with muscle growth. They affect the pathways related to muscle hypertrophy in laboratory research subjects.

Potential Side Effects of Follistatin Peptide

Both follistatin 315 and 344 have proven potential influence in experimental models in laboratory research; they may also cause some side effects. Although these side effects were effectively managed in laboratory research, it is still necessary to be aware of them to ensure the research proceeds in the right direction. Here are a few side effects observed in research subjects during clinical trials:

• Fatigue
• Headache
• Exercise intolerance
• Tendinopathy
• Fibrosis
• Hyperplasia

Note: If researchers encounter any of these side effects, they must thoroughly review the research guidelines, protocols, and the research environment.

Legal Status

Neither follistatin 315 nor follistatin 344 is approved for human consumption. The Food and Drug Administration (FDA) has not approved these compounds for use in humans. Additionally, the World Anti-Doping Agency (WADA) prohibits their use in competitive sports. However, they are widely used in laboratory research on non-human experimental models.

Which one is Better: Follistatin 315 or 344?

The selection of the best option is subjective and varies from researcher to researcher. It also depends on the research environment and the physiological structure of experimental models. Moreover, for localized action in the laboratory, follistatin 344 is considered the best option for research subjects. On the other hand, for systemic and more general influence, follistatin 315 is regarded as the top choice for clinical trials on experimental models.

Final Thought

Follistatin 315 and 344 are the isoforms of the naturally occurring follistatin peptide. They differ in structure, mechanism, and potential benefits, but they also share the same follistatin peptide. Currently, they are strictly prohibited for human consumption, as the FDA and WADA in the United States do not permit them. Furthermore, selecting the best choice depends on the research environment and goals of the clinical trials.

Disclaimer: We strictly prohibit the use of these compounds for human purposes. They are only allowed to use them in laboratory research by scientists or researchers. Moreover, terms such as experimental models, research subjects, and research models used in this document refer to non-human participants used in laboratory research.

Frequently Asked Questions (FAQs)

What is the best place to buy follistatin 315 and 344 online?

The best place to buy follistatin 315 and 344 is BehemothLabz. BehemothLabz has built an enormous base of loyal customers, most of whom are repeat customers, which shows the level of trust and reliability. Additionally, our prices are reasonable and within the purchasing range of our customers, while maintaining the high quality of the compound. Our payment method is safe and secure and strictly prohibits third-party access to your personal information.

What are the benefits of follistatin 315 peptide?

The benefits of follistatin 315 peptide include its influence on pathways associated with muscle hypertrophy, physiology, and skeletal integrity in research subjects during preclinical trials.

Does follistatin affect muscle hypertrophy in experimental models?

Yes, follistatin may influence the biomarkers linked with muscle hypertrophy in experimental models, as studied in preclinical trials.

Is follistatin legal to buy?

Yes, follistatin is legal to buy for laboratory research and exploration. However, the FDA and WADA of the United States prohibit its use for human consumption.

References:

1. Keutmann, Henry T., Alan L. Schneyer, and Yisrael Sidis. “The role of follistatin domains in follistatin biological action.” Molecular endocrinology 18.1 (2004): 228-240.
2. Datta-Mannan, Amita, et al. “An engineered human follistatin variant: insights into the pharmacokinetic and pharmacodynamic relationships of a novel molecule with broad therapeutic potential.” The Journal of pharmacology and experimental therapeutics 344.3 (2013): 616-623.
3. Kaneko, Hiroyuki. “Follistatin.” Handbook of hormones. Academic Press, 2016. 298-e33C.
4. Patel, Ketan. “Follistatin.” The International Journal of Biochemistry & Cell Biology 30.10 (1998): 1087-1093.