Bemethyl (Bemetil) – Product Details

• Bemethyl (Bemetil) capsules are offered as 250mg per capsule for 30 capsules, totaling 7.5g.

Modern pharmacology has focussed a lot of research on learning more about new biologically active substances and how they could in the future affect the human body in different ways. Benzimidazole and its derivatives have had interesting potential effects on the nervous system, such as being psychostimulating, neuroleptic, antidepressant, sedative, anticonvulsive, and sleep-inducing. One of these derivatives, called bemitil, has been investigated in clinical settings a lot, especially to prevent psychogenic reactions in critical situations and stop them when they happen.

Notably, it has been studied to possibly help in asthenia, a condition that causes generalized fatigue, and to lessen the severity of seizures that were caused by experiments. Also, it has been found that Bemitil and other benzimidazole derivatives can potentially have either ergotropic or trophotropic effects, depending on the dose. [R]

Despite its longstanding clinical use and efficacy in correcting subclinical states, there is a lack of comprehensive understanding regarding the full spectrum of effects exerted by bemitil. This product was made by BehemothLabz to help researchers learn more about the effects of these compounds, not for human use:

• CAS No:  14610-11-8
• Chemical Formula: C9H11BrN2S
• Molar Mass: 259.17 g/mol
• IUPAC Name: 2-ethylsulfanyl-1H-benzimidazole;hydrobromide

What is Bemethyl?

Bemitil is also called 2-ethylbenzimidazole hydrobromide, which is its chemical name. It is sometimes called “bemithil,” “bemithyl,” or “bemethyl” in books written in English. It has also been called “bemactor” and “metaprot” in later works.

In the 1970s, Professor Vladimir Vinogradov and his research team at the Department of Pharmacology in the Military Medical Academy (then in Leningrad, USSR, now St. Petersburg, Russia) looked into a new group of compounds called “actoprotectors.” The result of their work was the creation of bemitil, which is the first and most widely studied actoprotector.

This early research into actoprotectors and the creation of bemitil afterward opened up new potential ways to improve physical and mental performance in research subjects. [R]

How Does Bemethyl Work?

In simpler terms, bemitil was found to have different effects on two types of neurons in the brainstem of subjects. It potentially reduced the activity of LC neurons, which are involved in noradrenaline signaling while increasing the activity of NR neurons, which are involved in serotonin signaling. This may have resulted in a relaxation response observed in the behavior of the cats. The compound also influenced the electrical brain activity, leading to reduced delta and theta waves in the EEG.[R]

Bemitil is a pharmacological agent with a metabolic mode of action that exerts a broad range of potential effects. It has the potential to activate the cell genome, leading to the expression of RNA and proteins, including enzymes and proteins involved in the immune system. This activation results in the synthesis of gluconeogenesis enzymes, which may aid in the utilization of lactate and the resynthesis of carbohydrates. These processes contribute to a potential increase in physical working capacity. Bemitil also enhances the synthesis of mitochondrial enzymes and structural proteins within the mitochondria. This, in turn, may lead to an elevation in energy production and the maintenance of a balanced relationship between oxidation and phosphorylation. By promoting high-level ATP synthesis even under conditions of oxygen deficiency, bemitil exhibits apparent antihypoxic and anti-ischemic activity. Furthermore, bemitil has the potential to act as an indirect-action antioxidant by stimulating the biosynthesis of antioxidant enzymes, which helps protect against oxidative damage. [R]

Below are other research-based additional benefits Bemethyl brings:

Bemethyl and Mutagenic Effect

In experiments conducted on cultured human whole blood, it was found that bemitil, along with other substances such as ascorbic acid, rutin, and a chemically modified flavonoid from Scutellaria Baicalensis Georgy, decreased or completely mitigated the clastogenic (chromosome-breaking) action of chrysotile-asbestos and zeolites. The effectiveness of bemitil, specifically, was confirmed by assessing chromosomal aberrations in the cells of peritoneal fluid and bone marrow in mice. It showed promise in preventing the mutagenic effects of chrysotile-asbestos.

The study suggests that the mutagenic effects of chrysotile-asbestos and zeolites are mediated by active oxygen species. The use of in vitro and in vivo models proved appropriate for investigating corpuscular mutagenesis. The findings highlight bemitil as a potential preventive agent against mutagenesis caused by chrysotile-asbestos, indicating its role in reducing chromosomal aberrations. [R] Further research in this area could explore additional preventive strategies and investigate the mechanisms underlying bemitil’s protective properties.

Bemethyl and Asthenic Conditions

In a study, the effects of the actoprotectant bemitil were compared to those of nootropic compounds like piracetam and piriditol. The study included 130 test subjects with asthenia caused by unclear forms of neuro-mental disturbances. Patients were treated with either continuous or intermittent bemitil in accordance with a treatment protocol developed during the study. Bemitil was more effective than piracetam and piriditol in treating the asthenic symptom complex as a whole, as demonstrated by the study’s findings. Bemitil exhibited a more rapid onset of therapeutic effects and a distinct, mild psychostimulant action, which was especially apparent in its impact on the fundamental symptoms of asthenic disorders. It was discovered that the level of the compound’s psychotropic effect varies depending on the treatment regimen employed. [R]

It is important to note that further research and studies are needed to fully understand the mechanisms of action of bemitil and its precise effects on asthenic conditions. 

Bemethyl and Liver Regeneration

Bemithyl, etomerzol, and yakton are three recently created medications that can potentially hasten the process of liver regeneration after partial hepatectomy. According to the study, these medications increase liver mass quickly, raise nucleic acid and glycogen levels, and improve the liver’s functionality. A decline in blood bilirubin levels and a shorter amount of time spent in hexenal-induced sleep are indicators of this improvement.

Also, it was shown that bemithyl, etomerzol, and yakton had a favorable effect on the liver’s morphology and the process of intracellular regeneration. Interestingly, riboxin and potassium orotate, which are well-known stimulants of liver regeneration and are derived from purine and pyrimidine bases, were outperformed by these novel medications’ regenerative ability.[R]

The research on liver regeneration has advanced significantly as a result of the study’s findings. This experimental study lays a solid groundwork for future research and potential therapeutic uses on pronounced impaired liver function, even though additional studies are required to clarify the precise mechanisms of action of Bemetila alone.

Bemethyl and Lupus Erythematosus Systemicus

LES or Lupus Erythematosus Systemicus is an autoimmune disease that affects various parts of the body, including the skin, joints, kidneys, heart, lungs, brain, and blood cells. Lupus occurs when the body’s immune system mistakenly attacks healthy tissues, leading to inflammation and damage.

A recent study investigated the effects of bemithyl on lupus erythematosus systemicus (LES) test subjects. The study involved assessing the levels of autoantibodies against DNA in the blood serum and the severity of the disease before, during, and after an 8-week treatment period. Different groups of test subjects received different treatments, including prednisolonum alone, prednisolonum in combination with cyclophosphane (CP), bemithyl alone, or bemithyl in combination with CP. The study revealed that introducing bemithyl into the treatment regimen had a significant positive impact. It led to a notable decrease in the levels of autoantibodies against DNA in the blood, as measured through immunoassay techniques. Additionally, the severity of LES, as evaluated using standard scales, showed significant improvement.[R]

These findings suggest that bemithyl may  be a valuable addition to the treatment approach for LES. By possibly reducing autoantibody levels and improving disease severity, bemithyl shows its effectiveness in managing LES. Combining bemithyl with CP yielded similar positive results, indicating potential synergistic effects.However, further research is needed to delve deeper into the mechanisms of action and potential side effects of bemithyl, as well as to validate these findings in larger test subjects

Bemethy as Actoprotectors

Bemitil has been found to have a positive impact on both mental performance and increased physical stamina, even in challenging conditions such as hypoxia, extreme temperatures, and high exertion in research subjects. It improves reaction time, cognitive processes, and the ability to follow instructions. Bemitil also exhibits antiasthenic properties, that aid to accelerate recovery processes after periods of intense physical exertion. Importantly, it does not cause psychomotor agitation. When subjected to extreme factors such as heavy physical loads, bemitil influences carbohydrate and energy metabolism in research subjects. It leads to slight decreases in glycogen and creatine phosphate levels in the liver and muscles, as well as reduced glucose levels in the blood of subjects. It also limits the accumulation of lactates in tissues and blood, and moderates increases in heat production and oxygen consumption in these subjects. Once the period of exertion concludes, bemitil facilitates the rehabilitation of these metabolic factors, with maximum effect development.

The potential therapeutic effects of bemitil are attributed to its complex mechanism, which involves the activation of the cell genome, optimization of mitochondrial enzymes oxidation, reduction of pronounced antioxidant effect, and stimulation of cellular immune response. However, the precise mechanisms by which bemitil influences RNA and protein expression remain unknown. [R] Further research is needed to know the specific mechanisms underlying bemitil’s effects on RNA and then proteins, energy production, the body’s resistance, limiting factors, and if the pronounced effect persists in research subjects.

Frequently Asked Questions

Is Bemethyl legal?

Since 2018, the World Anti-Doping Agency has been keeping track of bemethyl as part of its Monitoring Program.[R]

Bemethyl is intended for research purposes only.

Conclusion

Bemitil is a versatile pharmacological agent that offers various potential benefits for health. It has been found to positively influence mental and physical performance in both normal and extreme conditions in specific research subjects. Bemitil improves reaction time, cognitive processes, and overall work capacity in subjects. It also exhibits antiasthenic properties, aiding in the recovery process after intense physical exertion, without causing psychomotor agitation in subjects. This may enhance energy production and promotes antioxidant activity. Bemitil also has the potential in preventing mutagenic effects, improving liver regeneration, and treating conditions like lupus erythematosus. While Bemitil’s precise mechanisms of action are not yet fully understood, ongoing research aims to uncover more about how Bemitil works.

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Strength	250mg/30ct/7.5g, 250mg/60ct/15g

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